Juan Manuel Fernández
A5048669370- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Animal Disease Management and Epidemiology
- Genetic factors in colorectal cancer
- Orthopaedic implants and arthroplasty
- Advanced Glycation End Products research
- Colorectal Cancer Screening and Detection
- Bone health and treatments
- T-cell and Retrovirus Studies
- Polyoxometalates: Synthesis and Applications
- BRCA gene mutations in cancer
- HIV/AIDS Research and Interventions
- Metabolism, Diabetes, and Cancer
- Knee injuries and reconstruction techniques
- HIV-related health complications and treatments
- Silicon Nanostructures and Photoluminescence
- Osteoarthritis Treatment and Mechanisms
- Semiconductor materials and devices
- Bone and Joint Diseases
- Vector-Borne Animal Diseases
- Graphene and Nanomaterials Applications
Universidad Nacional de La Plata
2013-2024
Hospital Posadas
2024
Fundación Ciencias Exactas y Naturales
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2023
University of Buenos Aires
2023
Hospital de Poniente
2017-2023
Hospital Universitario de Gran Canaria Doctor Negrín
2018-2022
Laboratoire des Matériaux Avancés
2020
Instituto de Investigación Biosanitaria de Granada
2007-2015
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
2010-2014
BackgroundExposure to xenoestrogens during pregnancy may disturb the development and function of male sexual organs.ObjectiveIn this study we aimed determine whether combined effect environmental estrogens measured as total effective xenoestrogen burden (TEXB) is a risk factor for urogenital malformations.MethodsIn case–control study, nested in mother–child cohort (n = 702) established at Granada University Hospital, compared 50 newborns with diagnosis cryptorchidism and/or hypospadias 114...
Hydroxyapatite (HAP)-containing poly-ε-caprolactone (PCL)–polydiisopropyl fumarate (PDIPF) composite (Blend) was developed as an alternative for bone tissue engineering. The physicochemical, mechanical and biocompatibility properties of these composites were evaluated using two osteoblast-like cell lines (UMR106 MC3T3E1) compared with the blend without HAP PCL/HAP films. increment in elastic modulus decrease elongation-at-break Blend–HAP suggest that scaffolds have improved significantly....
A broader extent of amino acid substitutions in the integrase HIV-2 compared with HIV-1 might enable greater cross-resistance between raltegravir and dolutegravir infection. Few studies have examined virological response to patients that failed raltegravir.All recorded Spanish cohort were examined. The coding region was sequenced viraemic patients. Changes associated resistance recorded.From 319 HIV-2-infected cohort, 53 sequences from 30 individuals obtained (20 naive 10 experienced). Only...
In contrast with HIV-1, information about drug resistance in HIV-2 is scarce and mainly derived from small series of patients failing antiretroviral therapy. The spectrum changes the reverse transcriptase (RT), protease (PR) integrase (INT) genes was examined individuals enrolled Spanish register. From a total 236 HIV-2-infected registered Spain 1989 to June 2010, 53 PR, 44 RT 8 INT sequences were obtained. Low plasma viraemia precluded collection this most remaining cases. No major...
The present study was designed to investigate the possible cytotoxicity and biocompatibility of scaffolds based on previously characterized polymeric materials including poly--caprolactone (PCL) or polydiisopropyl fumarate (blended their own), with without hydroxyapatite (HAP).Water contact angle also evaluated determine hydrophylicity each scaffold.Degradation different after a 10-week incubation in Dulbecco's modified eagle medium (DMEM) supplemented 5% (v/v) fetal bovine serum (FBS).Bone...
Abstract There is considerable interest in the design of polymeric biomaterials that can be used for repair bone defects. In this study, we ultrasound to prepare a compatibilized blend poly(ε-caprolactone) (PCL) and poly(diisopropyl fumarate) (PDIPF). The formation post-sonication inter-polymer coupling products was verified by SEC analysis with azo-labeled PDIPF. We also analyzed physicochemical mechanical properties blend. When compared PCL alone, PCL/PDIPF showed no difference its...
HIV-2 is a neglected virus despite estimates of 1-2 million people being infected worldwide. The naturally resistant to some antiretrovirals used treat HIV-1 and therapeutic options are limited for patients with HIV-2.In this retrospective observational study, we analysed all HIV-2-infected individuals treated integrase strand transfer inhibitors (INSTIs) recorded in the Spanish cohort. Demographics, treatment modalities, laboratory values, quantitative RNA CD4 counts as well drug resistance...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) causes about 10% of cases end stage renal disease. Disease progression rate is heterogeneous. Tolvaptan presently the only specific therapeutic option to slow function decline in adults at risk rapidly progressing ADPKD with chronic (CKD) stages 1–4. Thus, a reliable evaluation patients needed. Methods We evaluated agreement between measured (mGFR) and estimated glomerular filtration (eGFR) by 61 formulas based on...
Current efforts in bone tissue engineering have as one focus the search for a scaffold material that supports osteoblast proliferation, matrix mineralization, and, ultimately, formation.Electrospraying of polymer solutions has enabled porous materials to meet current challenges replacement therapies.Porous scaffolds poly(-caprolactone)/poly(diisopropyl fumarate) compatibilized blend were obtained by electrospraying technique order create better osteophilic environment growth and...
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed the second recipient at month due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains but asymptomatic. infection recognized retrospectively donor, native Spaniard who had sex partners endemic...
We previously showed that a 3-week oral metformin (MET) treatment enhances the osteogenic potential of bone marrow stromal cells (BMSCs) and improves several histomorphometric parameters in Wistar rats with metabolic syndrome (MetS). However, skeletal effects extended periods MET need to be completely elucidated. Hence, this study, impact prolonged (3-month) was investigated on architecture, biomechanics variables, BMSCs or without MetS.
Abstract The objective of this study was to test a regenerative medicine strategy for the regeneration articular cartilage. This approach combines microfracture subchondral bone with implant at site cartilage defect supporting biomaterial in form microspheres aimed creating an adequate biomechanical environment differentiation mesenchymal stem cells that migrate from marrow. possible inflammatory response these biomaterials previously studied by means culture RAW264.7 macrophages. were...
An initial Phase III clinical trial has evaluated the efficacy and safety of biosimilar recombinant human growth hormone (rhGH; Omnitrope(®), Sandoz) in Spanish children with deficiency (GHD). At end study, those patients still growing were offered to remain on treatment (as usual practice), continued be monitored. The aim this study was determine adult height achieved by who participated trial, evaluate long-term rhGH treatment.This a multicenter, observational, retrospective follow-up (70...
Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis asymptomatic carriers frequently leads to late diagnoses.A nationwide HTLV-1 register was created in Spain 1989. A total 351 had been reported by the end 2017. We examined all new diagnoses during last decade and compared their clinical presentation.A 247 individuals infection since year 2008. The incidence has remained stable 20-25 yearly....