A5007374219- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Phagocytosis and Immune Regulation
- T-cell and Retrovirus Studies
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- Folate and B Vitamins Research
- Genomics, phytochemicals, and oxidative stress
- Animal Disease Management and Epidemiology
- Dementia and Cognitive Impairment Research
- Sulfur Compounds in Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Redox biology and oxidative stress
- Diet and metabolism studies
- Neonatal Health and Biochemistry
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Finance, Taxation, and Governance
- Alzheimer's disease research and treatments
- Fibroblast Growth Factor Research
- NF-κB Signaling Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Spanish Literature and Culture Studies
Leiden University
2025
Universitat de València
2015-2024
Hospital de Poniente
2023
Hospital Universitario de Torrejón
2022
Hospital La Paz Institute for Health Research
2022
Instituto de Investigación Biomédica de Málaga
2020
Universidad de Málaga
2012-2020
Hospital Universitario La Paz
2019
Instituto de Investigación Sanitaria La Fe
2017
Benemérita Universidad Autónoma de Puebla
1995
Significance: Nuclear factor kappa B (NF-κB) is a master regulator of the inflammatory response and represents key regulatory node in complex signaling network. In addition, selective NF-κB transcriptional activity on specific target genes occurs through control redox-sensitive interactions. Recent Advances: The mediated by redox-modulated complexes with ribosomal protein S3 (RPS3), Pirin (PIR). cAMP element-binding (CREB)-binding (CBP)/p300, peroxisome proliferator-activated receptor gamma...
Alzheimer disease (AD) is the main cortical neurodegenerative disease. The incidence of this increases with age, causing significant medical, social and economic problems, especially in countries ageing populations. This review aims to highlight existing evidence how vascular dysfunction may contribute cognitive impairment AD, as well therapeutic possibilities that might arise from evidence. hypothesis emerged an alternative amyloid cascade explanation for pathophysiology AD. locates blood...
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity diabetes mellitus, acting tools helping control caloric intake. Aspartame is metabolized phenylalanine, aspartic acid, methanol. Our aim was study effect chronic administration aspartame on glutathione redox status trans-sulphuration pathway mouse liver. Mice were divided into three groups: control; treated daily with for 90 days; plus N-acetylcysteine (NAC)....
Abstract Obesity is associated with local and systemic complications in acute pancreatitis. PPARγ coactivator 1α (PGC‐1α) a transcriptional master regulator of mitochondrial biogenesis that exhibits dysregulation obese subjects. Our aims were: (1) to study PGC‐1α levels pancreas from lean or rats mice pancreatitis; (2) determine the role inflammatory response during pancreatitis elucidating signaling pathways regulated by PGC‐1α. Lean Zucker C57BL6 were used first; subsequently, wild‐type...
Abstract Chromatin remodeling seems to regulate the patterns of proinflammatory genes. Our aim was provide new insights into epigenetic mechanisms that control transcriptional activation early- and late-response genes in initiation development severe acute pancreatitis as a model inflammation. changes were studied by chromatin immunoprecipitation analysis, nucleosome positioning, determination histone modifications promoters vivo course taurocholate-induced necrotizing rats vitro rat...
Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), common complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although is known that good metabolic control essential for preventing DR, knowledge disease incomplete and an effective treatment with no side effects lacking. Pterostilbene (Pter), natural stilbene antioxidant activity, has proved to beneficially affect different pathologies,...
Although there is scientific evidence of the presence immunometabolic alterations in major depression, not all patients present them. Recent studies point to association between an inflammatory phenotype and certain clinical symptoms with depression. The objective our study was classify depression disorder using supervised learning algorithms or machine learning, based on oxidative stress biomarkers lifestyle habits.
Background: Predicting which individuals with Parkinson's disease (PD) will develop cognitive deficits is challenging, but important towards selecting those at higher risk of progression for personalized early intervention and enriching samples clinical trials modifying agents. Objective: To examine whether practice effects on tests across one-year are predictive eventual impairment (CI) dementia (PDD) in PD. Methods: Individuals PD ( n = 549) from the PPMI database who were cognitively...
Background Obesity is a prognostic factor for severity in acute pancreatitis humans. Our aim was to assess the role of oxidative stress and abdominal fat increased obese rats. Methodology Taurocholate-induced performed lean Zucker Levels reduced glutathione, oxidized L-cysteine, cystine, S-adenosylmethionine were measured pancreas as well activities serine/threonine protein phosphatases PP1 PP2A tyrosin phosphatases. Isoprostane, malondialdehyde, triglyceride, free fatty acid levels lipase...