A5051631944- Retinal Diseases and Treatments
- Microtubule and mitosis dynamics
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Cellular transport and secretion
- Sirtuins and Resveratrol in Medicine
- Neonatal and fetal brain pathology
- Advanced Glycation End Products research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Muscle Physiology and Disorders
- Adenosine and Purinergic Signaling
- Retinopathy of Prematurity Studies
- Selenium in Biological Systems
- Cardiac Ischemia and Reperfusion
- Engineering Applied Research
- Genetic Neurodegenerative Diseases
- Sulfur Compounds in Biology
- Vehicle emissions and performance
- Endoplasmic Reticulum Stress and Disease
- Hemoglobin structure and function
- Neurological Disease Mechanisms and Treatments
Parc Científic de la Universitat de València
2024-2025
Universitat de València
2021-2024
Instituto de Investigación Sanitaria La Fe
2022-2024
Inserm
2022-2024
Université Paris Cité
2022-2024
Stanford University
2012-2023
NeuroDiderot
2022
Sorbonne Paris Cité
2022
Délégation Paris 7
2022
Leitat Technological Center
2019-2021
Mutations in Pten-induced kinase 1 (PINK1) are linked to early-onset familial Parkinson's disease (FPD). PINK1 has previously been implicated mitochondrial fission/fusion dynamics, quality control, and electron transport chain function. However, it is not clear how these processes interconnected whether they sufficient explain all aspects of pathogenesis. Here we show that also controls motility. In Drosophila, downregulation dMiro or other components the machinery rescued dPINK1 mutant...
Chronic hyperglycemia is a major driver of neurovascular damage in diabetic retinopathy (DR), leading cause preventable blindness adults. DR progression often undetected until its advanced stages, with oxidative stress recognized as primary contributor. In diabetes, disrupts retinal cellular balance, damaging proteins, DNA, and lipids, triggering photoreceptor degeneration. Pterostilbene (Pter), polyphenol antioxidant properties, has demonstrated protective effects animal models was assessed...
Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), common complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although is known that good metabolic control essential for preventing DR, knowledge disease incomplete and an effective treatment with no side effects lacking. Pterostilbene (Pter), natural stilbene antioxidant activity, has proved to beneficially affect different pathologies,...
Neuroglobin, a member of the globin superfamily, is abundant in brain, retina, and cerebellum mammals localizes to mitochondria. The protein exhibits neuroprotective capacities by participating electron transfer, oxygen supply, protecting against oxidative stress. Our objective was determine whether neuroglobin overexpression can be used treat neurological disorders. We chose Harlequin mice, which harbor retroviral insertion first intron apoptosis-inducing factor gene resulting depletion...
In neurons, a highly regulated microtubule cytoskeleton is essential for many cellular functions. These include axonal transport, regional specialization and synaptic function. Given the critical roles of microtubule-associated proteins (MAPs) in maintaining regulating stability dynamics, we sought to understand how this regulation achieved. Here, identify novel LisH/WD40 repeat protein, tentatively named nemitin (neuronal enriched MAP interacting protein), as potential regulator...
The loss of redox homeostasis induced by hyperglycemia is an early sign and key factor in the development diabetic retinopathy. Due to high level long-chain polyunsaturated fatty acids, retina highly susceptible lipid peroxidation, source pathophysiological alterations Previous studies have shown that pterostilbene, a natural antioxidant polyphenol, effective therapy against retinopathy development, although its protective effects on peroxidation are not well known. Plasma, urine retinas...
Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic factor (BDNF) has been considered as a target for therapeutic intervention several neurodegenerative diseases, including Huntington's disease (HD). To aid in the implementation such strategy, thorough understanding BDNF cortical-striatal transport is critical help guide its strategic delivery. In this manuscript, we investigate dynamic behavior along axis Q140 primary neurons, mouse model HD. We...
Brain is an oxyregulator organ, however extremely vulnerable to oxygen. Both high and low oxygen concentrations generate free radicals may cause oxidative stress damage because of insufficient response the antioxidant system. Hypoxic preconditioning (HP) exerts neuroprotective effects be a protecting tool against fluctuations, thus preventing neuronal in events such as ischaemia, acute hypoxia, stroke, or traumatic brain injury, among others. This review aims discuss molecular mechanisms...
<h3>Background</h3> Effective use of patient reported outcomes (PROs) is important for ensuring high quality care in rheumatoid arthritis (RA). The current standard to measure PROs at the point care. However, more frequent measures may provide a accurate representation disease activity. How best encourage patients report outside clinical setting not known. <h3>Objectives</h3> Initiate qualitative assessment RA patients9 preferences engagement PRO collection and electronic health...