A5086331676- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Noise Effects and Management
- Health disparities and outcomes
- Urban Green Space and Health
- Health Policy Implementation Science
- Climate Change and Health Impacts
- Behavioral Health and Interventions
- Medical Malpractice and Liability Issues
- Urban Transport and Accessibility
- Patient Safety and Medication Errors
- Physical Activity and Health
- COVID-19 and Mental Health
- Nutritional Studies and Diet
- Primary Care and Health Outcomes
- Effects and risks of endocrine disrupting chemicals
- Delphi Technique in Research
- Child and Adolescent Health
- Dental Health and Care Utilization
- Land Use and Ecosystem Services
- Urban Agriculture and Sustainability
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
Bradford Teaching Hospitals NHS Foundation Trust
2016-2025
Bradford Royal Infirmary
2015-2025
National Health Service
2016-2025
University of Bradford
2015-2024
University of York
2020-2024
Hull York Medical School
2024
University of Crete
2022
New York University
2022
University of Liverpool
2022
Murdoch Children's Research Institute
2020-2021
Abstract The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden possible causes in community, we coordinated analyses survey data from 6907 self-reported COVID-19 10 UK longitudinal study (LS) samples 1.1 million diagnostic codes electronic healthcare records (EHR) collected by spring 2021. Proportions presumed cases LS reporting any symptoms for 12+ weeks ranged 7.8% 17% (with 1.2 to 4.8%...
The authors explore the role of affective attitudes in predicting 14 health-promoting or health-risk behaviors.Participants (n = 390) completed questionnaire measures and cognitive attitude and, 1 month later, reported their intentions behavior.The outcome this study were Time 2 self-report intention behavior.A series hierarchical regression analyses revealed that was a significantly more powerful predictor behavior than for 9 behaviors. Also, had direct effect on not fully mediated by In...
Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused single exposure–health effect relationships. The "exposome" concept encompasses the totality exposures from conception onward, complementing genome.Objectives: Early-Life Exposome (HELIX) project is a new collaborative that aims implement novel exposure assessment and biomarker methods characterize early-life multiple factors...
Rare gene knockouts in adult humans On average, most people's genomes contain approximately 100 completely nonfunctional genes. These loss-of-function (LOF) mutations tend to be rare and/or occur only as a single copy within individuals. Narasimhan et al. investigated LOF Pakistani population with high levels of consanguinity. Examining alleles that were identical by descent, they found, expected, an absence homozygote for certain protein-coding However, also identified many no apparent...
The current study explored the association between green space and depression in a deprived, multiethnic sample of pregnant women, examined moderating mediating variables.
Contemporary epidemiological methods testing the associations between green space and psychological well-being treat all vegetation cover as equal. However, there is very good reason to expect that variations in ecological "quality" (number of species, integrity processes) may influence link access benefits human health well-being. We test relationship quality restorative benefit an inner city urban population Bradford, UK. selected 12 parks for study where we carried out botanical faunal...
Abstract Background COVID‐19 vaccines can offer a route out of the pandemic, yet initial research suggests that many are unwilling to be vaccinated. A rise in spread misinformation is thought have played significant role vaccine hesitancy. To maximize uptake, it important understand why has been able take hold at this time and may pose more problem within certain contexts. Objective people's beliefs, their interactions with (mis)information during attitudes towards vaccine. Design...
Essential to exposome research is the collection of data on many environmental exposures from different domains in same subjects. The aim Human Early Life Exposome (HELIX) study was measure and describe multiple during early life (pregnancy childhood) a prospective cohort associate these with molecular omics signatures child health outcomes. Here, we recruitment, measurements available baseline HELIX populations.The represents collaborative project across six established ongoing longitudinal...
BACKGROUND: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups.OBJECTIVES: Our study aimed systematically assess association between a wide array early-life childhood using an exposome-wide approach.METHODS: The HELIX (Human Early Life Exposome) measured child body mass index (BMI), waist circumference, skinfold thickness, fat in 1,301 children...
Abstract Introduction Co‐production with communities is increasingly seen as best practice that can improve the quality, relevance and effectiveness of research service delivery. Despite this promising position, there remains uncertainty around definitions co‐production how to operationalize it. The current paper describes development a strategy guide work ActEarly multistakeholder preventative programme children's health in Bradford Tower Hamlets, UK. Methods used Appreciative Inquiry (AI),...
Two studies investigated the impact of affective and cognitive messages compared to a no-message control on self-reported exercise. Students (Study 1, N = 383 Study 2, 197) were randomly allocated one three conditions (control – no message, message or message). Participants completed questionnaire measures tapping components theory planned behaviour in relation exercise reported their level (3 weeks later). In need for affect (NFA) cognition (NFC) also completed. Results showed that...
The research tested the efficacy of planning and partner-based interventions to promote physical activity over six months.Local government (council) employees (N = 257) were randomly allocated one four conditions (collaborative implementation intentions; partner-only; control group) before completing measures at baseline follow-ups 1, 3 6 months. Outcome comprised validated self-report activity: international questionnaire (IPAQ; Craig et al., 2003) walking exercise tables (SWET; Prestwich...
Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited.To characterize concentrations in pregnant women from Europe their children, based on chemical analysis biological samples mother-child pairs.We relied the Early-Life Exposome project, HELIX, collaborative project across six established population-based birth cohort studies Europe. In 1301 subjects, biomarkers 45 (i.e. organochlorine...
Background Patient and public involvement (PPI) is often an essential requirement for research funding. Distinctions can be drawn between clinical research, which generally focuses on patients, implementation health professional behaviour. There uncertainty about the role of PPI in this latter field. We explored defined roles to inform relevant good practice guidance. Methods used a structured consensus process using convenience sample panel nine experienced two researcher members. drew...
BackgroundSeveral single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied an exposome approach. We aimed to evaluate the association between a broad range prenatal and postnatal lifestyle exposures function in children.MethodsIn this analysis, we used data from 1033 mother–child pairs European Human Early-Life Exposome (HELIX) cohort (consisting six existing longitudinal birth cohorts France, Greece, Lithuania, Norway, Spain, UK...
Background and Aims Per‐ polyfluoroalkyl substances (PFAS) are widespread persistent pollutants that have been shown to hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure PFAS associates with established serum biomarkers of liver injury alterations metabolome children. Approach Results used data from 1,105 mothers their children (median age, 8.2 years; interquartile range, 6.6‐9.1) the European Human Early‐Life Exposome cohort...
Environment and diet in early life can affect development health throughout the course. Metabolic phenotyping of urine serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies children combining analyses these biological fluids are lacking. Here, we sought characterise major determinants child define metabolite associations with age, sex, BMI dietary habits European children, by exploiting unique biobank...