A5082040338- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Per- and polyfluoroalkyl substances research
- Fatty Acid Research and Health
- Gestational Diabetes Research and Management
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Asthma and respiratory diseases
- Child Nutrition and Water Access
- Toxic Organic Pollutants Impact
- Liver Disease Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Neonatal Respiratory Health Research
- Thermoregulation and physiological responses
- Folate and B Vitamins Research
- Occupational Health and Performance
- Pregnancy and preeclampsia studies
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health and Lifestyle Studies
- Energy and Environment Impacts
- Magnesium in Health and Disease
Universitat Pompeu Fabra
2023-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2023-2025
Barcelona Institute for Global Health
2021-2025
University of Southern California
2019-2022
University of Crete
2012-2021
Maastricht University
2015-2021
Harokopio University of Athens
2009-2016
Maastricht University Medical Centre
2016
Crete University Press
2014
Toxicant-associated steatohepatitis has been described in adults but less is known regarding the role of toxicants liver disease children. Perfluoroalkyl substances (PFAS) cause hepatic steatosis rodents, few previous studies have examined PFAS effects on severity injury We aimed to examine relationship histologic nonalcoholic fatty (NAFLD) Seventy-four children with physician-diagnosed NAFLD were recruited from Children's Healthcare Atlanta between 2007 and 2015. Biopsy-based histological...
Background and Aims Per‐ polyfluoroalkyl substances (PFAS) are widespread persistent pollutants that have been shown to hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure PFAS associates with established serum biomarkers of liver injury alterations metabolome children. Approach Results used data from 1,105 mothers their children (median age, 8.2 years; interquartile range, 6.6‐9.1) the European Human Early‐Life Exposome cohort...
Developing children are particularly vulnerable to the effects of exposure per- and polyfluoroalkyl substances (PFAS), a group endocrine disrupting chemicals. We hypothesized that early life PFASs is associated with poor metabolic health in children. studied association between prenatal postnatal mixture cardiometabolic children, role inflammatory proteins. In 1,101 mothers-child pairs from Human Early Life Exposome project, we measured concentrations PFAS blood collected pregnancy at 8...
Importance Prenatal exposure to ubiquitous endocrine-disrupting chemicals (EDCs) may increase the risk of metabolic syndrome (MetS) in children, but few studies have studied chemical mixtures or explored underlying protein and signatures. Objective To investigate associations prenatal EDC with MetS score children identify associated proteins metabolites. Design, Setting, Participants This population-based, birth cohort study used data collected between April 1, 2003, February 26, 2016, from...
Childhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) rich phenotypic characterization across two parts of Europe within population-based Human Early Life Exposome project, we unravel landscape childhood associated metabolic dysfunction. Our integrative analysis uncovers three clusters children defined by...
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into as a risk factor for asthma. However, little is known regarding role in incidence. We examined whether early-onset related phenotypes are associated with developing childhood. This study includes 21 130 children born from 1990 to 2008 Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden UK. followed non-obese at 3–4 years age incident up 8 age. Physician-diagnosed...
<h3>Importance</h3> The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health offspring to date is unknown. <h3>Objective</h3> To assess associations exposure with syndrome in children alterations biomarkers inflammation children. <h3>Design, Setting, Participants</h3> This population-based prospective birth cohort study used data studies performed 5 European countries (France, Greece, Norway, Spain, UK) between April 1, 2003, February 26,...
Abstract Objective To investigate whether high doses of folic acid supplementation in early pregnancy are associated with child neurodevelopment at 18 months age. Design The study uses data from the prospective mother–child cohort ‘Rhea’ study. Pregnant women completed an interviewer-administered questionnaire on 14–18 weeks gestation. Neurodevelopment was assessed use Bayley Scales Infant and Toddler Development (3rd edition). Red-blood-cell folate concentrations cord blood were measured a...
Background and Aims Nonalcoholic fatty liver disease (NAFLD) is the most prevalent cause of in children. Mercury (Hg), a ubiquitous toxic metal, has been proposed as an environmental factor contributing to toxicant‐associated disease. Approach Results We investigated effect prenatal exposure Hg on childhood injury by combining epidemiological results from multicenter mother–child cohort with complementary vitro experiments monocyte cells that are known play key role immune homeostasis NAFLD....
Maternal fish intake in pregnancy has been shown to influence fetal growth. The extent which affects childhood growth and obesity remains unclear.To examine whether is associated with offspring the risk of overweight obesity.Multicenter, population-based birth cohort study singleton deliveries from 1996 2011 Belgium, France, Greece, Ireland, Italy, Netherlands, Norway, Poland, Portugal, Spain, Massachusetts. A total 26,184 pregnant women their children were followed up at 2-year intervals...
BackgroundIt has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent which fish intake pregnancy child rhinitis symptoms remains unclear. We aimed assess whether seafood consumption is associated with childhood wheeze, allergic rhinitis.
Exposure to per- and polyfluoroalkyl substances (PFAS), a prevalent class of persistent pollutants, may increase the risk type 2 diabetes.We examined associations between PFAS exposure glucose metabolism in youth.Overweight/obese adolescents from Study Latino Adolescents at Risk Type Diabetes (SOLAR; n=310) participated annual visits for an average 3.3±2.9y. Generalizability findings were tested young adults Southern California Children's Health (CHS; n=135) who clinical visit with similar...
Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand alterations in response diet quality. Here, we used 1 H NMR spectroscopy multicountry study European children (1147 from 6 different cohorts) identified common panel of 4 urinary metabolites (hippurate, N -methylnicotinic acid, urea, sucrose) that was predictive Mediterranean adherence (KIDMED) ultra-processed food consumption also had higher capacity discriminating children’s quality...
Firefighting is one of the most hazardous occupations due to exposure per- and polyfluoroalkyl substances (PFAS) polycyclic aromatic hydrocarbons (PAHs). Such suspected affect cardiometabolic profile, e.g., liver function serum lipids. However, only a few studies have investigated impact this specific among firefighters. Men included in CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited training 58), controls 54). They completed questionnaires provided 1–3...
<title>Abstract</title> The rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), particularly among pediatric populations, requires identification modifiable risk factors to control progression. Per- and polyfluoroalkyl substances (PFAS) have emerged as potential contributors damage; however, their role in the etiology MASLD remains underexplored. This study aimed bridge gap between human epidemiological data vitro experimental findings elucidate effect...
Summary Objective To introduce ObMetrics, a free and user‐friendly Shiny app that simplifies the calculation, data analysis, interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies paediatric populations. We illustrate its usefulness using ethnically different populations comparative study prevalence across cohorts definitions. Methods conducted case from two diverse populations: Hispanic‐American cohort ( N = 1759) Hispanic‐European...
Rationale: Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood onset. Objectives: To determine if is associated with incident examine the role of medication in this association. Methods: We studied 8,716 children between ages 6 18.5 years who were nonobese at study entry participating 18 US cohorts Environmental influences on Child Health Outcomes program (among 7,299 complete covariate data mean [SD] age = 7.2 [1.6] follow up 5.3 [3.1] years)....
Maternal seafood intake during pregnancy and prenatal mercury exposure may influence children's growth trajectories.
Maternal pre-pregnancy weight is known to affect foetal development. However, it has not yet been clarified if gestational gain associated with childhood behavioural development.We performed a pooled analysis of two prospective birth cohorts investigate the association between and problem behaviours, effect modification maternal BMI. In total, 378 mother-child pairs from Maastricht Essential Fatty Acids Birth cohort (MEFAB) 414 Rhea Mother-Child were followed up early pregnancy 6-7 years...