A5031055272- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Bariatric Surgery and Outcomes
- Liver Disease and Transplantation
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Obesity, Physical Activity, Diet
- Liver Diseases and Immunity
- Obesity and Health Practices
- Hepatocellular Carcinoma Treatment and Prognosis
- Per- and polyfluoroalkyl substances research
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Birth, Development, and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Folate and B Vitamins Research
- Lipid metabolism and disorders
- Gastroesophageal reflux and treatments
- Nutritional Studies and Diet
- Endoplasmic Reticulum Stress and Disease
- Food Security and Health in Diverse Populations
- Alcohol Consumption and Health Effects
- Body Contouring and Surgery
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati Medical Center
2010-2025
University of Cincinnati
2016-2025
The Medical Center of Aurora
2023-2024
Fairfield Hospital
2023
Cincinnati Sportsmedicine and Orthopaedic Center
2010-2023
University of Antwerp
2023
City University of New York
2023
Yonsei University
2023
Princess Alexandra Hospital
2023
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236...
ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into most common seen pediatric population management challenge for general practitioners, subspecialists, health systems. In this guideline, expert committee on NAFLD reviewed summarized available literature, formulating recommendations to guide screening clinical care children with NAFLD.
Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining efficacy and safety weight-loss are available to support clinical decision making.
Abstract Diets high in saturated fat and fructose have been implicated the development of obesity nonalcoholic steatohepatitis (NASH) humans. We hypothesized that mice exposed to a similar diet would develop NASH with fibrosis associated increased hepatic oxidative stress be further reflected by plasma levels respiratory chain component, oxidized coenzyme Q9 (oxCoQ9). Adult male C57Bl/6 were randomly assigned chow, high-fat (HF), or high-carbohydrate (HFHC) diets for 16 weeks. The chow HF...
Bariatric surgery results in weight loss and health improvements adults adolescents. However, whether outcomes differ according to the age of patient at time is unclear.We evaluated effects Roux-en-Y gastric bypass a cohort adolescents (161 patients enrolled from 2006 through 2012) (396 2009). The two cohorts were participants related but independent studies. Linear mixed Poisson models used compare with regard coexisting conditions between 5 years after surgery. rates death subsequent...
<h3>Importance</h3> Severe obesity in childhood is a major health problem with few effective treatments. Weight-loss surgery (WLS) being used to treat severely obese adolescents, although very limited data regarding surgical safety for currently used, minimally invasive procedures. <h3>Objective</h3> To assess the preoperative clinical characteristics and perioperative outcomes of adolescents undergoing WLS. <h3>Design, Setting, Participants</h3> This prospective, multisite observational...
Inflammation plays a central pathogenic role in the pernicious metabolic and end-organ sequelae of obesity. Among these sequelae, nonalcoholic fatty liver disease (NAFLD) has become most common chronic developed world. The twinned observations that obesity is associated with increased activation interleukin (IL)-17 axis this can regulate damage diverse contexts prompted us to address IL-17RA signaling progression NAFLD. We further examined whether microbe-driven IL-17A regulated NAFLD...
<h3>Importance</h3> Nonalcoholic fatty liver disease (NAFLD) is a major chronic in children the United States and associated with insulin resistance. In adults, NAFLD also type 2 diabetes. To our knowledge, prevalence of diabetes unknown. <h3>Objective</h3> determine prediabetes assess as risk factors for nonalcoholic steatohepatitis (NASH). <h3>Design, Setting, Participants</h3> This was multicenter, cross-sectional study at 12 pediatric clinical centers across participating National...
Nonalcoholic fatty liver disease (NAFLD) may have distinct histological features in children and adults, but to date limited data are available on the spectrum significance of lesions pediatric patients. We conducted a multicenter study with well-characterized, biopsy-proven NAFLD (1) assess presence constellation (2) identify clinical laboratory predictors severity. One hundred thirty seen from 1995 2007 five centers United States Canada were studied. Clinical collected. Slides stained...
Background Non-alcoholic steatohepatitis (NASH) and resultant liver fibrosis is a major health problem without approved pharmacotherapy. Pre-clinical results of GR-MD-02, galectin-3 inhibitor, suggested potential efficacy in NASH with advanced fibrosis/cirrhosis prompted initiation clinical development programme fibrosis. Aim To evaluate the safety, pharmacokinetics exploratory pharmacodynamic markers GR-MD-02 subjects having bridging Methods The GT-020 study was first-in-human, sequential...
Non-alcoholic fatty liver disease (NAFLD) is a common chronic illness with genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis progression of NAFLD complex many unanswered questions. We conducted genome-wide association studies (GWASs) using both adult pediatric participants from the Electronic Medical Records Genomics (eMERGE) Network to identify novel genetic contributors this condition.First, natural...