Rebecca Cleeton
A5051636943- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Metabolomics and Mass Spectrometry Studies
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Biomedical Research and Pathophysiology
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Function and Risk Factors
- Folate and B Vitamins Research
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Biosensors and Analytical Detection
- Pregnancy and preeclampsia studies
- Drug Transport and Resistance Mechanisms
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Biochemical Analysis and Sensing Techniques
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Probiotics and Fermented Foods
Emory University
2013-2022
Children's Healthcare of Atlanta
2021-2022
Kenyon College
2009
Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction sugary foods and beverages is plausible but unproven treatment.To determine effects low in free sugars (those added to occurring naturally fruit juices) adolescent boys with NAFLD.An open-label, 8-week randomized clinical trial aged 11 16 years histologically diagnosed NAFLD evidence active (hepatic steatosis >10% alanine aminotransferase level ≥45 U/L) 1:1 an...
BACKGROUND. Hepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver disease (NAFLD). Improvements hepatic fat by dietary sugar reduction may be mediated reduced DNL, but data are limited, especially children. We examined the effects of 8 weeks restriction on DNL adolescents with NAFLD and correlations between other metabolic outcomes.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic in children, but diagnosis challenging due to limited availability of noninvasive biomarkers. Machine learning applied high‐resolution metabolomics and clinical phenotype data offers a novel framework for developing NAFLD screening panel youth. Here, untargeted by liquid chromatography–mass spectrometry was performed on plasma samples from combined cross‐sectional sample children adolescents ages 2‐25 years old with (n =...
Background Bacillus subtilis encounters a wide range of environmental pH. The bacteria maintain cytoplasmic pH within narrow range. Response to acid stress is poorly understood function external and permeant acids that conduct protons into the cytoplasm. Methods Principal Findings Cytoplasmic acidification benzoate transcriptome were observed in subtilis. was measured with 4-s time resolution using GFPmut3b fluorimetry. Rapid (pH 7.5 6.0) acidified B. cytoplasm, followed by partial recovery....
Background & AimsType 2 diabetes (T2D) is a growing problem in children. Children with NAFLD are at potentially high risk for developing T2D; however, the incidence of T2D this population unknown. This study aimed to determine children and identify associated factors.MethodsChildren enrolled Nonalcoholic Steatohepatitis Clinical Research Network were followed longitudinally. Incidence was determined by using clinical history fasting laboratory values. Cumulative curves developed time T2D. A...
Nonalcoholic fatty liver disease (NAFLD) has emerged as the major pediatric chronic disease, and it is estimated to affect more than one third of obese children in U.S. Cardiovascular complications are a leading cause increased mortality adults with NAFLD many adolescents already manifest signs subclinical atherosclerosis including carotid intima-media thickness.Volume intrahepatic fat was assessed 50 Hispanic-American, overweight adolescents, using Magnetic Resonance Spectroscopy....
Little is known regarding the subsequent course of non-alcoholic fatty liver disease (NAFLD) diagnosed in childhood. The objectives this single-center study were to gather data on long-term health outcomes and assess feasibility contacting former pediatric patients. In a large medical center, electronic records searched initially identify 162 patients who had biopsy between 2000 2010. Of these, 44 subjects met criteria for age at follow-up (≥18 year) biopsy-proven NAFLD, recruited via postal...
Nonalcoholic fatty liver disease (NAFLD) is the most common in children, and currently, there are no FDA-approved therapies. Plasminogen activator inhibitor-1 (PAI-1) elevated children with NAFLD associated increased severity. Losartan potassium (losartan) an angiotensin II receptor blocker (ARB) that reduces PAI-1 production improves insulin sensitivity has been proposed as a treatment for pediatric but not previously tested. This was 8-week randomized, double-blind, placebo-controlled,...
The National Institutes of Health (NIH) launched the Rapid Acceleration Diagnostics (RADxSM) Tech initiative to support development and commercialization novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care test devices. primary objective Clinical Studies Core (CSC) was perform SARS-CoV-2 device studies involving diverse populations settings. Within a few months, infrastructure for clinical developed, including master protocol, digital study platform, data...
Summary Background Non‐alcoholic fatty liver disease (NAFLD) has been shown to be an independent risk factor for cardiovascular disease. In adults, histologic severity of non‐alcoholic steatohepatitis (NASH) is associated with a more atherogenic profile. Objective To assess by lipoprotein profile in children NAFLD and compare assessment severity. Methods Nuclear magnetic resonance including particle sizes, apolipoproteins the insulin resistance (LP‐IR) index was measured serum samples...
ObjectivesTo determine SARS-CoV-2-antibody prevalence in pediatric healthcare workers (pHCWs).DesignBaseline of anti-SARS-CoV-2-IgG was assessed a prospective cohort study from large facility. Prior SARS-CoV-2 testing history, potential risk factors and anxiety level about COVID-19 were determined. Prevalence difference between emergency department (ED)-based non-ED-pHCWs modeled controlling for those covariates. Chi-square test-for-trend used to examine by month enrollment.ResultsMost 642...
Abstract There is an increasing need to understand long‐term metabolic changes and resultant comorbidities because life expectancy after pediatric kidney liver transplants. We evaluated differences in classic novel cardiometabolic biomarkers among obese normal weight adolescent transplant recipients. enrolled a total of 80 (mean±SD, 14.8 years ±3.0) recipients (63 kidney, 17 liver) with mean duration from transplantation 6.0 (±4.1) years. Among recipients, overweight individuals had higher...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic in children and may lead to cirrhosis requiring transplant. Thus, prompt diagnosis of advanced fibrosis essential. Our objectives were examine PRO‐C3 (a neo‐epitope pro‐peptide type III collagen formation) levels across childhood/adolescence associations with pediatric NAFLD. This cross‐sectional study included 88 adolescents biopsy‐proven NAFLD (mean age: 13.9 ± 2.9 years, 71% male) 65 healthy participants (11.8 4.5 38% male)....
Pediatric liver transplantation rejection affects 20% of children. Currently, biopsy, expensive and invasive, is the best method diagnosis. Discovery validation clinical biomarkers from blood or other biospecimens would improve care. For this study, stored plasma samples were utilized two cross-sectional cohorts transplant patients at Children's Healthcare Atlanta. High resolution metabolic profiling was completed using established methods. Children with (n = 18) without 25) acute cellular...
Context.— Diagnostic testing for SARS-CoV-2 in symptomatic and asymptomatic children remains integral to care, particularly supporting return attendance schools. The concordance of detection children, using various specimen types, has not been widely studied. Objective.— To compare 3 sample types polymerase chain reaction (PCR) collected tested at a single facility. Design.— We prospectively recruited 142 children/young adults into comparison study performed health care system. Each child...
Background & Aims Magnetic resonance-based steatosis measurement of the liver has become non-invasive gold standard; however very few diagnostic thresholds have been independently validated and none in children. This study was designed to validate thresholds, assess repeatability relationship histology a proprietary MRI volumetric fat fraction (VLFF) method (HepaFat-Scan®) magnetic resonance spectroscopy (MRS) proton density (PDFF) method. Methods cross-sectional assesses accuracy MRI-VLFF...