Nadia Ovchinsky
A5000185724- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Hematopoietic Stem Cell Transplantation
- Genetic and Kidney Cyst Diseases
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Cardiac Valve Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Congenital Heart Disease Studies
- Esophageal and GI Pathology
- Folate and B Vitamins Research
- Inflammatory Bowel Disease
- Kawasaki Disease and Coronary Complications
- Empathy and Medical Education
Children's Hospital at Montefiore
2016-2025
Albert Einstein College of Medicine
2016-2025
New York University
2023-2025
Columbia University Irving Medical Center
2010-2019
Goryeb Children's Hospital
2016-2019
Atlantic Health System
2016-2019
Columbia University
2010-2014
Center for Digestive and Liver Diseases
2014
Morgan Stanley Children's Hospital
2012-2013
NewYork–Presbyterian Hospital
2004
Health care delivery is increasingly evaluated according to quality measures, yet such measures are underdeveloped for cirrhosis. The Practice Metrics Committee of the American Association Study Liver Diseases was charged with developing explicit process‐based and outcome‐based adults We identified candidate from comprehensive reviews literature input expert clinicians patient focus groups. conducted an 11‐member clinician panel used a modified Delphi method systematically identify set in...
Summary Background Data on oral vancomycin for primary sclerosing cholangitis (PSC)‐associated inflammatory bowel disease (IBD) are limited. Aims Using data from the Paediatric PSC Consortium, to examine effect of IBD activity. Methods In this retrospective multi‐centre cohort study, we matched vancomycin‐treated and untreated patients (1:3) based duration at time outcome assessment. The was Physician Global Assessment (PGA) clinical activity after 1 year (±6 months) vancomycin. We used...
In patients with Alagille syndrome, cholestasis-associated clinical features can include high serum bile acids and severe pruritus that necessitate liver transplantation. We aimed to evaluate the efficacy safety of ileal acid transporter inhibitor odevixibat versus placebo in syndrome.
Background and Aims Many children with primary sclerosing cholangitis (PSC) receive oral vancomycin therapy (OVT) or ursodeoxycholic acid (UDCA). There is a paucity of data on whether these medications improve outcomes. Approach Results We analyzed retrospective from the Pediatric PSC Consortium. Children treated OVT were matched 1:1:1 to those UDCA managed observation (no treatment) based closest propensity score, ensuring similar baseline characteristics. Two hundred sixty‐four patients...
Abstract Background and Aims Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) associated acute liver injury (ALI) has been linked to poor outcomes in adults. Here we compare characteristics children with elevated ALT (E‐ALT) two distinct manifestations of the infection, multisystem inflammatory syndrome‐children (MIS‐C) coronavirus disease 2019 (COVID‐19). Methods This is a retrospective study patients ≤21 years age positive for SARS‐CoV‐2 PCR. E‐ALT was defined as alanine...
Importance Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, varicella are rising nationally internationally, leaving susceptible children at risk life-threating conditions. Objective To determine safety immunogenicity live pediatric liver kidney recipients. Design, Setting, Participants This...
Abstract The burden of HCC is substantial. To address gaps in care, the American Association for Study Liver Diseases (AASLD) Practice Metrics Committee (PMC) aimed to develop a standard set process‐based measures and patient‐reported outcomes (PROs) along care continuum. We identified candidate process based on structured literature review. A 13‐member panel with content expertise across continuum evaluated importance performance gap using modified Delphi approach (two rounds rating) define...
Disease progression in children with primary sclerosing cholangitis (PSC) is variable. Prognostic and risk-stratification tools exist for adult-onset PSC, but not children. We aimed to create a tool that accounts the biochemical phenotypic features early disease stage of pediatric PSC.
Increased mortality risk because of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection in adults with native liver disease (LD) and transplant (LT) is associated advanced age comorbid conditions. We aim to report outcomes for children LD LT enrolled the NASPGHAN/SPLIT SARS-CoV2 registry.
This cohort study assesses the protection provided by live attenuated viral vaccines among a pediatric population of solid organ transplant recipients 1 year after vaccination.
Abstract Objectives The trend of alanine aminotransferase (ALT), a biomarker metabolic dysfunction‐associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty disease), remains poorly described for the pediatric population because no widely accepted cutoffs are available to categorize ALT value. We nuanced changes in distribution continuous values. Study Design analyzed data from 15,702 adolescents aged 12–19 who participated National Health and Nutrition Examination...
Liver abnormalities in severe acute respiratory syndrome-coronavirus 2 infection, including hepatitis and cholestasis, have been observed adults are associated with worse outcomes. We describe adolescents cholestasis mild presentation of lacking typical symptoms. Our intention is to raise index suspicion for testing protective equipment use.
Adult SOT recipients with COVID-19 have higher mortality rates when compared to general population. There is paucity of data on outcomes in pediatric recipients.This a cross-sectional study investigating the prevalence infection and (heart, liver, kidney) recipients. We extracted demographic clinical characteristics testing (PCR or [Ab] test) results from medical records. Clinical were between patients who positive for Ab) those did not, using Mann-Whitney, Student's t test, chi-square test....
In adults, hepatic complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with significant morbidity and transplantation-related mortality (TRM). However, there is a paucity of parallel data on the incidence of, risk factors for, liver injury (LI) impact LI TRM in pediatric allo-HSCT recipients. We compared total bilirubin, direct alanine aminotransferase values before at 1 month, day +100, 12 months 248 patients who received either myeloablative...