A5020083060- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Impact on Reproduction
- Transplantation: Methods and Outcomes
- Pneumonia and Respiratory Infections
- Hematopoietic Stem Cell Transplantation
- Bacterial Genetics and Biotechnology
- Herpesvirus Infections and Treatments
- Fungal Infections and Studies
- Renal Transplantation Outcomes and Treatments
- Infectious Diseases and Mycology
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- CRISPR and Genetic Engineering
- Neutropenia and Cancer Infections
- Hepatitis B Virus Studies
- Genetics, Bioinformatics, and Biomedical Research
- Viral gastroenteritis research and epidemiology
- Antifungal resistance and susceptibility
The University of Texas Southwestern Medical Center
2024-2025
Duke Medical Center
2020-2025
Duke University
2018-2023
University of Pennsylvania
2009-2018
Children's Hospital of Philadelphia
2016-2018
Rutgers, The State University of New Jersey
2009
Importance Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, varicella are rising nationally internationally, leaving susceptible children at risk life-threating conditions. Objective To determine safety immunogenicity live pediatric liver kidney recipients. Design, Setting, Participants This...
ChvE is a chromosomally encoded protein in Agrobacterium tumefaciens that mediates sugar-induced increase virulence (vir) gene expression through the activities of VirA/VirG two-component system and has also been suggested to be involved sugar utilization. The homology several bacterial periplasmic sugar-binding proteins, such as ribose-binding galactose/glucose-binding Escherichia coli. In this study, we provide direct evidence specifically binds vir gene-inducing d-glucose with high...
Abstract Background Pediatric solid organ transplant (SOT) recipients are at increased risk for vaccine preventable illnesses (VPI). They frequently receive vaccines after transplantation when immunosuppressive medications and cytopenias may impact their immune response to routine childhood vaccines. Current guidelines recommend monitoring vaccine-specific serologies ensure optimal responses guide the need repeat doses. Methods In this single-center retrospective cohort study, a multivariate...
This cohort study assesses the protection provided by live attenuated viral vaccines among a pediatric population of solid organ transplant recipients 1 year after vaccination.
We present here the first published use of letermovir for treatment resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully combination foscarnet letermovir. After she transitioned monotherapy secondary prophylaxis, recurrent laboratory-confirmed ganciclovir,...
Children undergoing hematopoietic stem cell transplantation (HSCT) are at high risk for hospital-associated bloodstream infections (HA-BSIs). This study aimed to describe the incidence, microbiology, and factors HA-BSI in pediatric HSCT recipients.We performed a single-center retrospective cohort of children adolescents (<18 years age) who underwent over 20-year period (1997-2016). We determined incidence case fatality rate by causative organism. used multivariable Poisson regression...
The recognition by a viral envelope of its cognate host-cell receptor is the initial critical step in defining host-range and tissue specificity. This study combines single-round selection random library with parallel cDNA screen for function to identify distinct retroviral envelope/receptor pair. 11-aa targeting domain modified feline leukemia virus consists constrained peptide. Critical binding peptide cellular are pair internal cysteines an essential Trp required maintenance titers >10(5)...
Curvularia is a saprophytic dematiaceous mold and rare human pathogen. Here, we report three severely immunocompromised pediatric patients who developed invasive infection. Diagnosis was achieved or confirmed in all cases by fungal ribosome sequencing, which hastened species identification targeted treatment for the reported. There are no guidelines infection, though were cured of their infection through combination surgical resection various anti-fungal therapies, indicating relatively low...
Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV has not been analyzed on a continuous scale in this population.All children ≤ 18 years age who underwent SOT single center between January 1, 2007 July 31, 2018 were included retrospective study. Transplant episodes which PTLD occurred compared to without PTLD. Multivariable logistic regression was used...
Influenza A virus (FluA), influenza B (FluB) and respiratory syncytial (RSV) illnesses increase hospitalizations during seasonal epidemics.To determine the utility of Simplexa FluA/B & RSV Direct Assay (Direct Flu/RSV) its impact on oseltamivir use, we offered this assay to emergency department (ED) patients with influenza-like illness.Utilization Flu/RSV provided a turnaround time (TAT) 2 hours. Compared flu season prior implementation Flu/RSV, clinicians were more likely prescribe 5 days...
Abstract Background Post-transplant lymphoproliferative disorder (PTLD), which is often driven by Epstein-Barr virus (EBV), causes significant morbidity and mortality in lung transplant recipients (LTRs). EBV viremia surveillance with reduction of immunosuppression at certain viral load thresholds a common strategy used to prevent PTLD or mitigate progression pre-clinical stages, but the utility adult seropositive LTRs poorly understood. Methods In retrospective cohort study adults who...
Diagnosing influenza is challenging in children as influenza-like illness (ILI) symptoms are nonspecific. A clinical pathway was introduced the emergency department (ED) of a large pediatric hospital to screen and treat patients at high risk influenza-related complications. new highly accurate, rapid polymerase chain reaction (PCR) test next year provide more timely results. We aimed measure impact PCR on rates all-cause ED readmissions subsequent admissions all with ILI discharged from ED....
Objective: The pattern of international co-author collaboration in molecular and genetic research remains unclear. We collected data from Medline report the results with graphical presentations using Google maps social network analysis (SNA). Methods: Downloading 6,732 abstracts on December 13, 2017 library keywords Molecular (Title) AND Genetic (Title), we reported following features: (1) nation journal distribution; (2) main frequently presented papers; (3) eminent author key indicators...
Abstract Background Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV has not been analyzed on a continuous scale in this population. Methods All children ≤ 18 years age who underwent SOT single center between January 1, 2007 July 31, 2018 were included retrospective study. Transplant episodes which PTLD occurred compared to without PTLD. Multivariable...