A5017063355- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Renal Transplantation Outcomes and Treatments
- Eosinophilic Esophagitis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Clinical Nutrition and Gastroenterology
- Cultural and Sociopolitical Studies
- Pharmacological Effects and Toxicity Studies
- Breastfeeding Practices and Influences
- Abdominal vascular conditions and treatments
- Infant Nutrition and Health
- Renal function and acid-base balance
- Hepatitis Viruses Studies and Epidemiology
Istanbul University
2015-2025
Children's Hospital of Eastern Ontario
2022
University of Ottawa
2022
University Medical Center Groningen
2022
University of Groningen
2022
Istanbul University-Cerrahpaşa
2021
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2012
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2012
Istanbul Memorial Hospital
2012
University of Pittsburgh
2002
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic in children and adolescents United States, probably also rest industrialized world.As prevalence NAFLD childhood increases with worldwide obesity epidemic, there an urgent need for diagnostic standards that can be commonly used by pediatricians hepatologists. To this end, we performed a PubMed search adult pediatric literature on diagnosis through May 2011 using Topics and/or relevant Authors as words. According to...
Progressive familial intrahepatic cholestasis (PFIC) is a group of inherited paediatric liver diseases resulting from mutations in genes that impact bile secretion. We aimed to evaluate the effects odevixibat, an ileal acid transporter inhibitor, versus placebo children with PFIC.Patients eligible for this 24-week, randomised, double-blind, completed, phase 3 study were outpatients diagnosed PFIC1 or PFIC2 who had pruritus and elevated serum acids at screening. Patients randomly assigned...
ABCD3 is one of three ATP-binding cassette (ABC) transporters present in the peroxisomal membrane catalyzing ATP-dependent transport substrates for metabolic pathways localized peroxisomes. So far, precise function not known. Here, we report identification first patient with a defect ABCD3. The presented hepatosplenomegaly and severe liver disease showed striking accumulation C27-bile acid intermediates plasma. Investigation parameters skin fibroblasts revealed reduced number enlarged...
In patients with Alagille syndrome, cholestasis-associated clinical features can include high serum bile acids and severe pruritus that necessitate liver transplantation. We aimed to evaluate the efficacy safety of ileal acid transporter inhibitor odevixibat versus placebo in syndrome.
Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis its natural history, effects predicted protein truncating mutations (PPTMs), and possible associations serum bile acid (sBA) concentrations surgical biliary diversion (SBD) with long-term outcome. We aimed provide insights by using the largest genetically defined cohort...
PEDFIC 2, an ongoing, open-label, 72-week study, evaluates odevixibat, ileal bile acid transporter inhibitor, in patients with progressive familial intrahepatic cholestasis.
Essential micronutrients are important for maintenance of life. Deficiency is more likely to be encountered in children, and women studies required investigate the status children women. This study aimed longitudinally evaluate changes zinc, copper, iron levels breastfed infants their mothers during first year Serum hair samples were obtained from 35 healthy (51 % males, 49 females) 2, 6, 12 months after delivery. All assessed using an atomic absorption spectrophotometer. determined by a...
Gastro-esophageal variceal hemorrhage (GEVH) is one of the major causes life-threatening gastrointestinal bleeding in children. Medical, endoscopic, angiographic, and surgical interventions can be utilized treatment. In this case report, we describe partial splenic artery embolization for refractory GEVH due to portal vein thrombosis. A 3-year-old male patient was admitted with abdominal distension. He had been followed up hepatosplenomegaly 2 years. The patient's body weight 15.5 kg...
Abstract The diagnosis and treatment of rare diseases present significant global challenges. This study aimed to identify the difficulties faced by specialists in management diseases, as well gather their recommendations for potential solutions. An expert committee specializing inborn metabolic disease genetics developed a comprehensive survey, which was then distributed online professionals working with diseases. A total 21 actively engaged participated survey. All participants acknowledged...
Cirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This well-defined entity adults, but pediatric data are limited. The aim of the study was to determine incidence, features, risk factors CCMP children portal hypertension (PHT).This included 50 cirrhotic PHT (40/50) noncirrhotic (10/50). Fifty healthy were also selected for control group. Electrocardiography...
ABSTRACT As pediatric liver transplantation comes of age, experts gathered to discuss current paradigms and define gaps in knowledge warranting research further improve patient graft outcomes. Identified areas ripe for collaborative include understanding the molecular cellular mechanisms tolerance role donor‐specific antibodies, considering ways expand donor pool, minimizing long‐term side effects immunosuppression, fine‐tuning surgical techniques minimize biliary vascular complications.
Data regarding agreement on endoscopic features of oesophageal varices in children with portal hypertension (PH) are scant. The aim this study was to evaluate visualisation and classification by several European clinicians, build a rational basis for future multicentre trials.Endoscopic pictures the distal oesophagus 100 clinical diagnosis PH were distributed 10 endoscopists. Observers requested classify variceal size according 3-degree scale (small, medium, large, class A), 2-degree (small...
Hepatotoxicity as a result of valproic acid therapy is well documented. Elevation in aminotransferase activities rarely associated with symptoms. It sometimes manifests acute liver failure. Here, we report 8-year-old girl who was referred for unresolving jaundice and itching 3 months. Past history revealed afebrile convulsion 5 months previously beginning treatment. Valproic discontinued after the development jaundice. Physical examination ichterus, xanthomas on extensor surfaces...
Here, we present the outcomes of 100 consecutive pediatric liver transplant patients in our center.Five hundred fifteen adult and transplants were performed at Organ Transplantation Center, Sisli Memorial Hospital, Istanbul, Turkey, between August 2006 November 2012. Of these, first retrospectively analyzed.One three children (mean age, 4.7 y; age range, 4.4 mo to 17.3 53% female, 47% male; mean body weight, 17.2 kg; 4.5 75 kg). Biliary atresia (27%) progressive familial intrahepatic...
We aimed in this study to investigate pre- and posttransplant clinical psychosocial features of the donors effects living-related liver transplantation possible relevant factors on outcome family functioning.Thirty-two living (19 females, age 31.84 ± 7.10 years) were evaluated. Medical records regarding psychological life evaluated.The parents (n=28, 87.6%) most. In pretransplant evaluation, 5 (19.3%) had anxiety postoperative complications quality life. Donors discharged from hospital a...
Hepatoportal Sclerosis in Childhood: Descriptive Analysis of 12 PatientsHepatoportal sclerosis (HPS) is defined as portal areas the absence cirrhosis.There little information about HPS children literature.The aim this study was to describe clinical presentation, associated disorders, laboratory characteristics and outcome who were diagnosed HPS.This included by Pathology Department between 2005 2011.Data collected from gastroenterology clinic charts retrospectively, including demographics,...
We aimed to investigate national allocation policies for pediatric liver transplantation (LT).A survey was prepared by the European Society Paediatric Gastroenterology Hepatology and Nutrition Committee in collaboration with North American Studies of Pediatric Liver Transplantation consortium. The sent hepatologists transplant surgeons worldwide. National data were obtained from centrally based registries.Replies 15 countries 5 world continents. Overall donation rate varied between 9 35 per...
Aim A high faecal calprotectin (FC) level is a non‐invasive marker for inflammatory bowel disease. Nevertheless, healthy infants have elevated levels of FC with large variations. The aim our study was to determine the and associated factors in aged 0–12 months. Methods Infants younger than 1 year age were follow‐up programme Well Child Unit. Data on clinical characteristics, including birth, anthropometric measurements feeding types unit, obtained from their personal health records. One...
Çeltik C, Ünüvar A, Aydoğan Gökçe S, Öztürk G, Güllüoğlu M, Yılmaz Türkoğlu Anak Sökücü Durmaz Ö. Human herpes virus type 8‐associated Kaposi sarcoma in a pediatric liver transplant recipient. Pediatr Transplantation 2011: 15: E100–E104. © 2010 John Wiley & Sons A/S. Abstract: Development of KS recipients is rare entity and has dismal prognosis. Latent HHV‐8 infection, immunosuppression, genetic predisposition are possible etiological factors. Decreasing the dose or cessation...
The aim of this study was to investigate whether the non-invasive serum marker FibroTest–ActiTest (FT–AT) reliably predicts histological stage fibrosis and/or activity, and decreases need for a liver biopsy. Twenty-five children with naïve chronic hepatitis B were analyzed haptoglobin, α2-macroglobulin, apolipoprotein A1, bilirubin, γ-glutamyl transferase, alanine aminotransferase FT–AT scores computed. compared data. FT predicted insignificant in 14/23 (61%) patients at cut-off level 0.31....