A5031185949- Hematopoietic Stem Cell Transplantation
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Neurogenetic and Muscular Disorders Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Mesenchymal stem cell research
- Blood Coagulation and Thrombosis Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Autoimmune and Inflammatory Disorders Research
- Erythrocyte Function and Pathophysiology
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Platelet Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Blood properties and coagulation
Acıbadem University
2015-2025
Acıbadem Adana Hospital
2020-2024
Istanbul University
2008-2023
Marmara University
2023
Istanbul University-Cerrahpaşa
2023
Acıbadem University Atakent Hospital
2015-2022
Kent Hastanesi
2020-2022
Cukurova University
2015
Necmettin Erbakan University
2015
Ankara University
2015
Twenty children with acute idiopathic thrombocytopenic purpura (ITP) were randomized to receive either oral megadose methylprednisolone (MDMP) or intravenous immunoglobulin G (IV IgG). Normal platelet counts (> = 150 x 10(9)/l) obtained in 6 patients of each group 3 days and 8 9 treated MDMP IV IgG within 1 week, respectively. It is concluded that could easily be used for the early elevation counts, which important ITP treatment.
Despite the introduction of new broad-spectrum antibiotics and antifungal therapies over past decade, infections remains most frequent cause death in patients with neutropenia. The aim this study is to assess effect safety granulocyte transfusions (GTX) for treatment severe life-threatening pediatric febrile neutropenia or defective functions.In study, 35 high-risk functions, who received 111 GTX, were included. GTX used 3 consecutive days during not responding antimicrobial therapy.The mean...
Abstract Primary hemophagocytic lymphohistiocytosis (p-HLH) can be cured with allogeneic haematopoietic stem cell transplantation (allo-HSCT). It remains unclear whether HSCT outcomes are affected by the presence of different genetic mutations. We used data obtained from children who underwent allo-HSCT for HLH to examine effects mutations on outcomes. Data 153 paediatric patients in 18 centres were retrospectively evaluated. Patients divided into four groups: 1) PRF1 mutation ( n = 46), 2)...
Respiratory syncytial virus (RSV) has been reported to cause severe morbidity and mortality among cancer patients receiving chemotherapy with or without autologous/allogeneic hematopoetic stem cell transplantation (HSCT). There have few reports describing the outcome of RSV infection specifically pediatric oncology patients.Two outbreaks developed between February-April 2006 January-March 2009 in hospitalized for various hemato-oncological diseases + - HSCT. A survey respiratory viruses was...
This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow a third-party donor for refractory aGVHD. We report first experience using MSCs to treat aGVHD in 33 pediatric patients undergoing allogeneic HSCT Turkey. Totally, 68 doses derived were infused. The median dose MSC was 1.18 × 10(6) per kg body weight. Overall, complete response (CR) documented 18 patients, partial (PR) 7 and no (NR) 8 patients. 2-year estimated probability overall survival (OS) achieving CR...
Therapeutic plasma exchange (TPE) is an effective treatment method in selective indications. Secondary to access and technical features, it more difficult apply pediatric population than adults. The aim of this study investigate safety, clinical indications, results critically ill patients who need TPE treatment. All the procedures performed a intensive care unit providing tertiary during 4 years (2015-2019) were evaluated retrospectively. (635) for 135 patients. Median age was 34 months...
Amac: Oksidan ve antioksidan dengedeki bozukluklar talasemi orak hucreli anemi gibi hemoglobinopatilerde saptanmistir. Calismada duzenli olarak transfuzyon yapilan selasyon tedavisi alan 11 beta major hastasinda oksidan ozellikler calisilmistir. Gerec yontem: Hastalarin laboratuar degerleri cinsiyet yaslari calisma grubuna uygun 10 saglikli cocuk ile karsilastirilmistir. Bulgular: Koruyucu bir olan eritrosit superoksid dismutazi (ESOD) lipit peroksidasyonunun yikim urunu plazma...
Abstract Viral infections remain one of the most important complications following allogeneic HSCT . Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral and outcome hundred seventy‐one patients (median 7.38 years) who underwent from matched related (MRD, n = 71), 10 HLA allele‐matched unrelated donors ( MUD 1; 29), 9 2; 40), haploidentical (n 31). PCR screening for BK virus, adenovirus, Epstein‐Barr parvovirus B19, human...
This prospective study evaluated 382 pediatric patients with peripheral lymphadenopathy (LA) presenting at the Pediatric Oncology and Hematology Departments of Social Security Children's Hospital Gazi University Medical Faculty Hospital. The ages ranged between 2 months 16 years (median 7 years); 72% were male. Of patients, 138 had localized LA (a single anatomic area involved), 171 limited (two or three areas 73 generalized ( four more involved). specific etiology (either benign malign) was...
✓ Spinal hydatid disease is a rare entity that frequently yields to severe, acute-onset neurological deficits. Although the gold standard treatment total surgical removal of cysts without inducing any spillage, it may not be possible perform this in patients with multiple and fragile cysts. In such cases, neural structures should adequately decompressed albendazole administered promptly. The authors describe case 13-year-old girl who was admitted history back pain lower-extremity weakness....
Fever of unknown origin (FUO) is defined as the body temperature higher than 38.3 degrees C on several occasions and lasting longer 3 weeks, with aetiology remaining uncertain after 1 week investigation. In this study, we reviewed 57 patients FUO hospitalised in our inpatient department between 1998 2003. The median age was 44 years (17-84), 26 were males (46%), while 31 females (54%). 24 (42%), infectious diseases such tuberculosis (12 patients) brucellosis (5 found under FUO. Inflammatory...
A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin (IgA) level during postoperative antibiotic anticonvulsant therapy. bone marrow examination revealed hemophagocytosis. Real-time PCR parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report spontaneous resolution B19-associated DIC.
Invasive fungal infections (IFIs) are a major cause of infection-related morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Data from pediatric settings scarce. To determine the incidence, risk factors outcomes IFIs 180-day period post-transplantation, 408 who underwent HSCT were retrospectively analyzed. The study included only proven probable IFIs. cumulative incidences IFI 2.7%, 5.0%, 6.5% at 30, 100, 180 days respectively. According...
Preimplantation genetic diagnosis involves the of a disorder in embryos obtained through vitro fertilization, selection healthy embryos, and transfer to mother's uterus. has been used not only avoid risk having an affected child, but it also offers, using HLA matching, preselection potential HLA-genoidentical donor progeny for sibling who requires bone marrow transplantation. Here, we share hematopoietic stem cell transplantation results 52 patients with different benign malign hematological...