Maura Faraci
A5052397178- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Acute Myeloid Leukemia Research
- Fungal Infections and Studies
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Neurological Complications and Syndromes
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Neonatal Health and Biochemistry
- Transplantation: Methods and Outcomes
- Pharmacological Effects and Toxicity Studies
- Eosinophilic Disorders and Syndromes
- Neuroblastoma Research and Treatments
- Bacterial Identification and Susceptibility Testing
- Chronic Myeloid Leukemia Treatments
Istituto Giannina Gaslini
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Ospedale Regina Margherita
2024
IRCCS Materno Infantile Burlo Garofolo
2024
Azienda Ospedaliera Universitaria Pisana
2024
ORCID
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2024
In-Q-Tel
2012-2015
Marche Polytechnic University
2014
University of Pittsburgh
2013
The objective of this analysis was to investigate prognostic factors that influence the outcome Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder (PTLD) after a rituximab-based treatment in allogeneic hematopoietic stem cell transplant (HSCT) setting. A total 4466 HSCTs performed between 1999 and 2011 19 European Group for Blood Marrow Transplantation centers were retrospectively analyzed PTLD, either biopsy-proven or probable disease. One hundred forty-four cases...
Background. The purpose of our study was to evaluate the incidence and clinical characteristics febrile episodes during neutropenia following chemotherapy in children with cancer.
Summary. This study aimed to ascertain whether extracorporeal photochemotherapy (ECP) is an effective treatment for paediatric patients with refractory graft‐versus‐host disease (GVHD). From January 1992 December 2000, 77 children (median age 8·6 years) either acute ( n = 33) or chronic 44) GVHD, resistant conventional immunosuppressive therapy, were treated ECP in four Italian hospitals. After ECP, GVHD involving skin, liver and gut responded completely 76%, 60% 75% of respectively. The...
Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), updated epidemiological investigation advisable.We prospectively evaluated the epidemiology pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) 1625 autologous (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for impact on 4-month overall-survival transplant.The cumulative...
BK virus-associated hemorrhagic cystitis (BKV-HC) is a severe complication after allogeneic hematopoietic stem cell transplantation (HSCT), but antiviral treatment for this condition has not been evaluated.We conducted retrospective survey on the safety and outcome of cidofovir patients with BKV-HC in centers affiliated European Group Blood Marrow Transplantation.From 1 April 2004 to 31 December 2007, 62 received diagnosis median interval 35 days HSCT (range, 3-577 days). Fifty-seven (92%)...
Autoimmune hematological diseases (AHDs) may occur after allogeneic hematopoietic stem cell transplantation (HSCT), but reports on these complications in large cohorts of pediatric patients are lacking. Between 1998 and 2011, 1574 consecutive children underwent HSCT 9 Italian centers. Thirty-three (2.1%) developed AHDs: 15 autoimmune hemolytic anemia (45%), 10 immune thrombocytopenia (30%), 5 Evans' syndrome (15%), 2 pure red aplasia (6%), 1 neutropenia (3%). The 10-year cumulative incidence...
Highlights•Thirty-three children with high-risk hematologic malignancies and lacking a match-related or -unrelated donor were treated PTCy haplo-HSCT in 5 Italian AIEOP centers.•Acute GVHD grades II to IV III chronic developed 22% (95% CI, 11 42), 3% 0 21), 4% 27) of children. The 1-year OS rate was 72% 56 88), PFS 61% 43 80), RI 24% 13 44), TRM 9% 3 26).•The univariate analysis for risk showed how significant variables, mother as (P = .02), gender female .04), significantly associated lower...
Dyskeratosis congenita (DC) is a genetic multisystem disorder with frequent involvement of the bone marrow. Haematopoietic stem cell transplantation (HSCT) only definitive cure to restore haematopoiesis, even though it cannot correct other organ dysfunctions. We collected data on outcome HSCT in largest cohort DC (n = 94) patients ever studied. Overall survival (OS) and event-free (EFS) at 3 years after were 66% 62%, respectively. Multivariate analysis showed better outcomes aged less than...
The onset of acute Graft-versus-Host Disease (aGvHD) has been correlated with the gut microbiota (GM) composition, but experimental observations are still few, mainly involving cohorts adult patients. In current scenario where fecal transplantation used as a pioneer therapeutic approach to treat steroid-refractory aGvHD, there is an urgent need expand existing observational studies GM dynamics in Hematopoietic Stem Cell Transplantation (HSCT). Aim present study explore trajectory 36...
Objective Progressive multifocal leukoencephalopathy (PML) is still burdened by high mortality in a subset of patients, such as those affected hematological malignancies. The aim this study was to analyze the safety and carry out preliminary evaluation efficacy polyomavirus JC (JCPyV)‐specific T cell therapy cohort patients with PML. Methods Between 2014 2019, 9 diagnosis “definite PML” according 2013 consensus who were showing progressive clinical deterioration received JCPyV‐specific...
To describe and evaluate the incidence risk factors of severe neurologic events (SNE) in pediatric recipients allogeneic or autologous hematopoietic stem cell transplantation (HSCT) for hematologic nonhematologic diseases.Retrospective analysis 272 consecutive children admitted to G. Gaslini Children's Research Institute given HSCT (70 from unrelated donors, 115 related 87 autologous) between June 1985 January 2001.Thirty-seven (13.6%) developed SNE after a median 90 days (range, 5 8.8...
Gonadal impairment is an important late effect with a significant impact on quality of life transplanted patients. The aim this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter included children pediatric European Society for Blood Marrow Transplantation (EBMT) centers between 1992 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137...
Abstract The oral and gastrointestinal mucosae represent the main targets of toxic effect chemo and/or radiotherapy administered during conditioning regimen before hematopoietic stem cell transplant (HSCT). These harmful consequences immunological complications that may occur after (such as Graft versus Host Disease, G v HD) are responsible for clinical symptoms associated with mucositis aplasia phase, like pain, nausea, vomiting, diarrhea. toxicities could play a critical role in...
In children with acute myeloid leukemia (AML) who lack a human leukocyte antigen (HLA) identical sibling, the donor can be replaced an HLA-matched unrelated (MUD) or haploidentical (haplo). We compared outcomes of patients <18 years AML in first and second complete remission (CR1 CR2) undergoing hematopoietic stem cell transplantation (HCT) either MUD anti-thymocyte globulin (ATG) (N=420) haplo HCT post-transplant cyclophosphamide (PT-CY) (N=96) after myeloablative conditioning regimen (MAC)...