A5065673637- Gut microbiota and health
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Genomics and Phylogenetic Studies
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Bacteriophages and microbial interactions
- Neutropenia and Cancer Infections
- Reproductive tract infections research
- Helicobacter pylori-related gastroenterology studies
- Synthesis and biological activity
- Urinary Tract Infections Management
- Infant Nutrition and Health
- Digestive system and related health
- Tryptophan and brain disorders
- Dietary Effects on Health
- Inflammatory Bowel Disease
- Enzyme Production and Characterization
- Oral microbiology and periodontitis research
- Synthesis and Biological Evaluation
- Bacterial Genetics and Biotechnology
- Pancreatic and Hepatic Oncology Research
- Anaerobic Digestion and Biogas Production
University of Bologna
2016-2025
Jackson and Tull (United States)
2021
Ecologie Microbienne Lyon
2019-2021
Research Centre for Cereal and Industrial Crops
2020
University of Roehampton
2019
American Neurogastroenterology and Motility Society
2012
Leiden University Medical Center
2012
University of Ferrara
2002
University of Catania
1993
University of Pavia
1992
Background Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections. Methodology/Principal Findings By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
<h3>Objectives</h3> Habitual diet plays a major role in shaping the composition of gut microbiota, and also determines repertoire microbial metabolites that can influence host. The typical Western corresponds to an omnivore; however, Mediterranean (MD), common culture, is date nutritionally recommended dietary pattern includes high-level consumption cereals, fruit, vegetables legumes. To investigate potential benefits MD this cross-sectional survey, we assessed microbiota metabolome cohort...
Human gut microbiota directly influences health and provides an extra means of adaptive potential to different lifestyles. To explore variation in understand how these bacteria may have co-evolved with humans, here we investigate the phylogenetic diversity metabolite production from a community human hunter-gatherers, Hadza Tanzania. We show that higher levels microbial richness biodiversity than Italian urban controls. Further comparisons two rural farming African groups illustrate other...
Objective Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We others have shown that frailty co-varies with alterations in the gut microbiota a manner accelerated consumption restricted diversity diet. The Mediterranean diet (MedDiet) associated health. In NU-AGE project, we investigated if 1-year MedDiet intervention could alter reduce Design profiled 612 non-frail or pre-frail subjects across five European...
Abstract The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate propionate, are end-products microbial fermentation macronutrients that distribute systemically via blood. aim this study was to investigate transcriptional response immature LPS-matured monocyte-derived DC SCFA. Our data revealed distinct effects exerted by each individual SCFA on gene expression DC,...
Background: Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections.Methodology/Principal Findings: By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
Age-related alterations in human gut microbiota composition have been thoroughly described, but a detailed functional description of the intestinal bacterial coding capacity is still missing. In order to elucidate contribution metagenome complex mosaic longevity, we applied shotgun sequencing total fecal DNA selection samples belonging well-characterized ageing cohort. The age-related trajectory microbiome was characterized by loss genes for shortchain fatty acid production and an overall...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes longevity is still missing. Here using combined metabonomics approach compromising holistic (1)H-NMR and targeted MS approaches, we report for first time well characterized human cohort mostly female centenarians, elderly, young individuals. With increasing age, blood serum displayed marked decrease tryptophan concentration, while an...
The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from mutualistic ecosystem layout are considered key environmental factor contributing to the disease. Thus, possibility of improving metabolic control T2D by correcting microbiome dysbioses through diet has been evaluated. Here, we explore potential two different energy-restricted dietary approaches - fibre-rich macrobiotic Ma-Pi or recommended Italian professional societies for treatment correct patients. In previous...
Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense muscle mass, with effects upon morbidity quality life. The gut microbiome has recently emerged as a key environmental modifier human health that can modulate healthy aging possibly longevity. However, its associations adiposity in old age are still poorly understood. Here we profiled microbiota well-characterized cohort 201 Italian elderly subjects...
Objective The engagement of the gut microbiota in development symptoms and complications diverticular disease has been frequently hypothesised. Our aim was to explore colonic immunocytes, metabolome patients with a descriptive, cross-sectional, pilot study. Design Following colonoscopy biopsy questionnaire phenotyping, were classified into diverticulosis or symptomatic uncomplicated disease; asymptomatic subjects served as controls. Mucosal region unaffected sites, quantified...
Abstract Gut microbes programme their metabolism to suit intestinal conditions and convert dietary components into a panel of small molecules that ultimately affect host physiology. To unveil what is behind the effects key on microbial functions way they modulate host–microbe interaction, we used for first time multi-omic approach goes mere gut phylogenetic composition provides an overall picture functional repertoire in 27 fecal samples from omnivorous, vegan vegetarian volunteers. Based...
Background: Butyric acid (BA) is a short-chain fatty (SCFA) with anti-inflammatory properties, which promotes intestinal barrier function. Medium-chain acids (MCFA), including caproic (CA), promote TH1 and TH17 differentiation, thus supporting inflammation. Aim: Since most SCFAs are absorbed in the cecum colon, measurement of BA peripheral blood could provide information on health status ecosystem. Additionally, given different immunomodulatory properties CA evaluation their serum...
A new therapeutic approach for inflammatory bowel diseases is based on the administration of probiotic bacteria. Prokaryotic DNA contains unmethylated CpG motifs which can activate immune responses, but it unknown whether bacterial involved in beneficial effects obtained by treatment. Peripheral blood mononuclear cells (PBMC) from healthy donors were incubated with pure eight strains and total human feces collected before after ingestion. Cytokine production was analyzed culture...