A5082616655- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Pharmaceutical studies and practices
- DNA Repair Mechanisms
- Respiratory viral infections research
- Hemoglobinopathies and Related Disorders
- MRI in cancer diagnosis
Princess Máxima Center
2016-2025
University Medical Center Utrecht
2015-2024
Wilhelmina Children's Hospital
2013-2024
Utrecht University
2013-2024
Stichting Kinderoncologie Nederland
2009-2023
Memorial Sloan Kettering Cancer Center
2022
Emma Kinderziekenhuis
2008-2016
The Netherlands Cancer Institute
2016
NHS Blood and Transplant
2016
Sheba Medical Center
2016
Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning. We investigated whether preparative combination chemotherapy could replace TBI such patients.FORUM a randomized, controlled, open-label, international, multicenter, phase III, noninferiority study. Patients ≤ 18 years at diagnosis, 4-21 HSCT, complete remission pre-HSCT, and an...
We retrospectively analyzed results of unrelated cord blood transplantation (UCBT) in 93 Fanconi anemia (FA) patients. Median age at was 8.6 years (1-45). The units transplanted were HLA-A, -B, or -DRB1 identical 12 cases, 1 HLA mismatch 35 and 2 3 differences 45 cases. median number nucleated cells (NC) CD34+ infused recipient weight 4.9x10(7)/kg 1.9x10(5)/kg, respectively. Participating centers selected the preparative regimen their choice, 57 patients (61%), it included Fludarabine....
Allogeneic hematopoietic cell transplantation (HCT) is the only treatment able to prevent progressive neurodegenerative disease in a selected group of mucopolysaccharidosis (MPS) disorders. However, its use was historically limited by high risk graft failure and transplantation-related morbidity mortality. Therefore, since 2005 new international HCT guidelines for MPS disorders were proposed. The survival outcomes patients receiving according these 2 European centers expertise evaluated. Two...
Objective. To determine the genotype–phenotype association in patients with adenosine deaminase-2 (ADA2) deficiency due to identical homozygous R169Q mutations CECR1.
Abstract Extracellular vesicles (EVs) are widely studied regarding their role in cell-to-cell communication and disease, as well for applications biomarkers or drug delivery vehicles. EVs contain membrane intraluminal proteins, affecting structure thereby likely functioning. Here, we use atomic force microscopy mechanical characterization of erythrocyte, red blood cell (RBC), from healthy individuals patients with hereditary spherocytosis (HS) due to ankyrin deficiency. While these packed...
Highlights•TBI and Bu-based preparative regimens confer equivalent survival post-HCT in adult ALL.•More relapse, trend for less cGVHD multivariate analysis.•TBI-based good disease control, but more TRM.AbstractTotal body irradiation (TBI) has been included standard conditioning acute lymphoblastic leukemia (ALL) before hematopoietic cell transplantation (HCT). Non-TBI have incorporated busulfan (Bu) to decrease toxicity. This retrospective study analyzed TBI Bu on outcomes of ALL patients...
Abstract Purpose Cancer‐related fatigue is one of the most distressing side effects childhood cancer treatment. Physical activity can decrease and has positive on other health outcomes. Most research physical pertains to adults, few studies that focus children have limited follow‐up time. This study evaluates cancer‐related in its association with over a one‐year time period. Methods Sixty‐eight (7–18 years) were recruited during or within first year after (Actical monitor) (Pediatric...
The addition of fludarabine to cyclophosphamide as a lymphodepleting regimen prior CD19 chimeric antigen receptor (CAR) T-cell therapy significantly improved outcomes in patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Fludarabine exposure, previously shown be highly variable when dosing is based on body surface area (BSA), predictor for survival allogeneic hematopoietic cell transplantation (allo-HCT). Hence, we hypothesized that an optimal exposure might...
The ALL10 protocol improved outcomes for children with ALL by stratifying and adapting therapy into three minimal residual disease-defined risk groups: standard risk, medium (MR), high risk. IKZF1-deleted (IKZF1del) in the largest MR group still showed poor outcome, line protocols worldwide, accounting a number of overall relapses. toxicity Down syndrome (DS) excellent outcome ETV6::RUNX1 ALL. Poor prednisone responders (PPRs) were treated as ALL10. In ALL11, we prolonged IKZF1del from 2 to...