A5075070173- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Oral health in cancer treatment
- Family Support in Illness
- Neutropenia and Cancer Infections
- Palliative Care and End-of-Life Issues
- Head and Neck Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Cancer survivorship and care
- Cancer Risks and Factors
- Reproductive Biology and Fertility
- Pharmaceutical studies and practices
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Neuroblastoma Research and Treatments
- Pediatric Pain Management Techniques
- Hematological disorders and diagnostics
- Adolescent and Pediatric Healthcare
- Thyroid Cancer Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Ethics and Legal Issues in Pediatric Healthcare
- Hematopoietic Stem Cell Transplantation
Princess Máxima Center
2010-2025
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Beatrix Kinderziekenhuis
2009-2025
University Medical Center Utrecht
2023
Sotiria General Hospital
2023
Patan Academy of Health Sciences
2023
Panagiotis & Aglaia Kyriakou Children's Hospital
2023
National and Kapodistrian University of Athens
2023
Erasmus MC
2006-2022
Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term of SMNs in a well-characterized cohort 5-year CCSs, with particular focus on individual chemotherapeutic agents and solid risk. Methods The Dutch Cancer Oncology Group-Long-Term Effects After includes 6,165 CCSs diagnosed between 1963 2001 Netherlands. were identified by linkages Netherlands Registry, Pathology medical chart review. calculated standardized...
To update a clinical practice guideline (CPG) for the empiric management of fever and neutropenia (FN) in pediatric patients with cancer hematopoietic cell transplantation recipients.The International Pediatric Fever Neutropenia Guideline Panel reconvened to conduct second this CPG. We updated previous systematic review identify new randomized controlled trials (RCTs) evaluating any strategy FN patients. Using Grading Recommendations Assessment, Development Evaluation framework, evidence...
Background.Normally, humans are protected against infections by their anaerobic intestinal microorganisms providing colonization resistance. In immunocompromised patients, the endogenous gram-positive and gram-negative pathogens often cause infectious complications. Therefore, we analyzed effect of chemotherapy treatment antimicrobial prophylaxis on bacterial populations (microbiota) among pediatric patients with acute myeloid leukemia who prone to mucositis infections. Methods.During 36...
To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients.Recommendations were developed by an international multidisciplinary panel that included patient advocate. We conducted systematic review of children adults HSCT recipients. The Grading Recommendations Assessment, Development, Evaluation approach was used to make strong or weak recommendations classify level evidence as...
Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals this study were to evaluate risk heart failure, temporal changes by periods, and factors childhood survivors ( CCS ). Methods Results DCOG‐LATER (Dutch Childhood Oncology Group–Long‐Term Effects After Cancer) cohort includes 6,165 5‐year diagnosed between 1963 2002. Details on prior diagnosis collected nationwide cohort. Cause‐specific cumulative incidences obtained. Cardiac...
Malnutrition in childhood cancer patients has been associated with lower health-related quality of life (HRQOL). However, this association never actually tested. Therefore, we aimed to determine the between nutritional status and HRQOL children cancer.In 104 children, aged 2-18 years diagnosed hematological, solid, or brain malignancies, were assessed at diagnosis 3, 6, 12 months using child- parent-report versions PedsQL 4.0 Generic scale 3.0 Cancer Module. Scores on both scales range from...
The ALL10 protocol improved outcomes for children with ALL by stratifying and adapting therapy into three minimal residual disease-defined risk groups: standard risk, medium (MR), high risk. IKZF1-deleted (IKZF1del) in the largest MR group still showed poor outcome, line protocols worldwide, accounting a number of overall relapses. toxicity Down syndrome (DS) excellent outcome ETV6::RUNX1 ALL. Poor prednisone responders (PPRs) were treated as ALL10. In ALL11, we prolonged IKZF1del from 2 to...