A5041206659- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Radiation Dose and Imaging
- Estrogen and related hormone effects
- Effects of Radiation Exposure
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- RNA Research and Splicing
- DNA Repair Mechanisms
- HER2/EGFR in Cancer Research
- Head and Neck Cancer Studies
- Occupational and environmental lung diseases
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
- Chemotherapy-induced cardiotoxicity and mitigation
- Radioactivity and Radon Measurements
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- Air Quality and Health Impacts
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
Medizinische Hochschule Brandenburg Theodor Fontane
2019-2025
Zimmer Biomet (United States)
2020-2024
The Netherlands Cancer Institute
2014-2023
Oncode Institute
2013-2023
Brandenburg University of Technology Cottbus-Senftenberg
2022-2023
University of Potsdam
2022
Klinikum Brandenburg
2022
Dutch Cancer Society
2011-2019
Zimmer Biomet (Germany)
2019
Leiden University
2019
Most invasive breast cancers are classified as ductal carcinoma not otherwise specified (IDC NOS), whereas about 25% defined histological 'special types'. These special-type categorized into at least 17 discrete pathological entities; however, whether these also constitute molecular entities remains to be determined. Current therapy decision-making is increasingly governed by the classification of cancer (luminal, basal-like, HER2+). The derived from mainly IDC NOS and it unknown this...
Cardiovascular diseases are increasingly recognized as late effects of Hodgkin lymphoma (HL) treatment. The purpose this study was to identify the risk factors for coronary heart disease (CHD) and quantify radiation dose heart, chemotherapy, other cardiovascular factors.We conducted a nested case-control in cohort 2,617 5-year HL survivors, treated between 1965 1995. Cases were patients diagnosed with CHD their first event after HL. Detailed treatment information collected from medical...
The study aim was to determine the risk of cataract among radiologic technologists with respect occupational and nonoccupational exposures ionizing radiation personal characteristics. A prospective cohort 35,705 cataract-free US aged 24-44 years followed for nearly 20 (1983-2004) by using two follow-up questionnaires. During period, 2,382 cataracts 647 extractions were reported. Cigarette smoking >or=5 pack-years; body mass index >or=25 kg/m(2); history diabetes, hypertension,...
Computed tomography (CT), a strong diagnostic tool, delivers higher radiation doses than most imaging modalities. As CT use has increased rapidly, protection is important, particularly among children. We evaluate leukemia and brain tumor risk following exposure to low-dose ionizing from scans in childhood.For nationwide retrospective cohort of 168 394 children who received one or more Dutch hospital between 1979 2012 were younger age 18 years, we obtained cancer incidence, vital status,...
Breast implants are among the most commonly used medical devices. Since 2008, number of women with breast diagnosed anaplastic large-cell lymphoma in (breast-ALCL) has increased, and several reports have suggested an association between risk breast-ALCL. However, relative absolute risks breast-ALCL still unknown, precluding evidence-based counseling about implants.To determine implants.Through population-based nationwide Dutch pathology registry we identified all patients primary non-Hodgkin...
Background:Hodgkin lymphoma (HL) survivors are at increased risk for developing valvular heart disease (VHD). We evaluated the determinants of and radiation dose-response.
<b>Objective</b> To estimate the risk of breast cancer associated with diagnostic radiation in carriers BRCA1/2 mutations. <b>Design</b> Retrospective cohort study (GENE-RAD-RISK). <b>Setting</b> Three nationwide studies (GENEPSO, EMBRACE, HEBON) France, United Kingdom, and Netherlands, <b>Participants</b> 1993 female mutations recruited 2006-09. <b>Main outcome measure</b> Risk estimated a weighted Cox proportional hazards model time dependent individually cumulative dose, based on nominal...
Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term of SMNs in a well-characterized cohort 5-year CCSs, with particular focus on individual chemotherapeutic agents and solid risk. Methods The Dutch Cancer Oncology Group-Long-Term Effects After includes 6,165 CCSs diagnosed between 1963 2001 Netherlands. were identified by linkages Netherlands Registry, Pathology medical chart review. calculated standardized...
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, physical biological agents that cause cancer in humans has evaluated about 1000 since 1971. are written by ad hoc Working Groups (WGs) of international scientific experts over a period 12 months ending an eight-day meeting. WG evaluates all the publicly available information each substance and, through transparent rigorous...
Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent examinations before age 22 years in nine countries. Radiation doses the active bone marrow were estimated on basis body part scanned, patient...
Triple-negative breast cancer (TNBC) is considered aggressive, and therefore, virtually all young patients with TNBC receive (neo)adjuvant chemotherapy. Increased stromal tumor-infiltrating lymphocytes (sTILs) have been associated a favorable prognosis in TNBC. However, whether this association holds for who are node-negative (N0), (< 40 years), chemotherapy-naïve, thus can be used chemotherapy de-escalation strategies, unknown.We selected N0 diagnosed between 1989 2000 from Dutch...
To our knowledge, WSG-ADAPT-HR+/HER2- (ClinicalTrials.gov identifier: NCT01779206; n = 5,625 registered) is the first trial combining 21-gene expression assay (recurrence score [RS]) and response to 3-week preoperative endocrine therapy (ET) guide systemic in early breast cancer.Baseline postendocrine Ki67 (Ki67post) were evaluated centrally. In trial, all patients received exclusively ET: with pathologic regional lymph node status (pN) 0-1 (ie, 0-3 involved nodes) entered control arm if RS...
In industrial workers, formaldehyde exposure has been associated with cancer of the nasal cavities, nasopharynx, prostate, lung, and pancreas; however, these associations are inconsistent remain controversial. Animals exposed to show excesses cancer. an extended follow-up a large cohort formaldehyde-exposed authors evaluated mortality from solid cancers (1,921 deaths) among 25,619 workers (865,708 person-years) employed in 10 US formaldehyde-producing or -using facilities through 1994....
Excess mortality from lymphohematopoietic malignancies, in particular myeloid leukemia, and brain cancer has been found surveys of anatomists, pathologists, funeral industry workers, all whom may have worked with formaldehyde. We investigated the relation to work practices formaldehyde exposure levels among these professionals address risk industry. Professionals employed who died between January 1, 1960, 1986, malignancies (n = 168) or tumors 48) (ie, case subjects) were compared deceased...
BackgroundFormaldehyde exposure is associated with leukemia in some epidemiological studies. In the National Cancer Institute's formaldehyde cohort, previously followed through December 31, 1979, and updated 1994, was an increased risk for leukemia, particularly myeloid that peak average intensity of exposure.
Many U.S. factory workers are exposed to formaldehyde. Although increased risks for leukemia have been found in medical and other professionals formaldehyde, studies industrial workers, who thought higher exposures, shown inconsistent associations. We extended follow-up of a cohort evaluate the association between formaldehyde exposure lymphohematopoietic cancers.The consisted 25 619 (865 708 person-years) employed before January 1, 1966, at one 10 plants followed through December 31, 1994....
Abstract There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light elevated indoor air levels new homes and occupational exposures experienced by workers care, embalming, manufacturing, other industries. Epidemiologic studies suggest that exposure is associated with an increased risk leukemia. However, biological plausibility these findings has been questioned because limited information available on ability to disrupt hematopoietic function....
Abstract BACKGROUND Workers exposed to low doses of radiation can provide information regarding cancer risks that are public concern. However, characterizing risk at requires large populations and ideally should include a proportion women, both which rarely available. METHODS Among 90,305 radiologic technologists in the U.S. (77% women) who were followed during 1983–1998, data concerning incident occurrence was obtained from mailed questionnaires death records. Standardized incidence ratios...
<h3>Background</h3> Childhood cancer survivors (CCSs) have an increased risk of morbidity and mortality. We evaluated the prevalence determinants left ventricular (LV) dysfunction in a large cohort long-term CCSs treated with different potentially cardiotoxic therapies. <h3>Methods</h3> The study consisted all adult 5-year who were therapies visited our late effects outpatient clinic. Echocardiography was performed patients had received anthracyclines, cardiac irradiation, high-dose...
BackgroundBreast cancer cells deficient for BRCA1 are hypersensitive to agents inducing DNA double-strand breaks (DSB), such as bifunctional alkylators and platinum agents. Earlier, we had developed a comparative genomic hybridisation (CGH) classifier based on BRCA1-mutated breast cancers. We hypothesised that this BRCA1-likeCGH could also detect loss of function due other causes besides mutations and, consequently, might predict sensitivity DSB-inducing agents.Patients methodsWe evaluated...