A5013712087- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cancer survivorship and care
- Family Support in Illness
- Reproductive Biology and Fertility
- Renal and related cancers
- Cancer Risks and Factors
- Palliative Care and End-of-Life Issues
- Lymphoma Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Birth, Development, and Health
- Medical Imaging Techniques and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Gestational Diabetes Research and Management
- Chemotherapy-induced organ toxicity mitigation
- Acute Myeloid Leukemia Research
- Pharmaceutical studies and practices
- Hematopoietic Stem Cell Transplantation
- Cardiac Imaging and Diagnostics
- Pregnancy and preeclampsia studies
- Venous Thromboembolism Diagnosis and Management
- CNS Lymphoma Diagnosis and Treatment
- Ovarian function and disorders
- Advanced MRI Techniques and Applications
- Reproductive Health and Technologies
Princess Máxima Center
2019-2024
Emma Kinderziekenhuis
2015-2024
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2019-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2010-2023
University of Oklahoma Health Sciences Center
2023
University Medical Center Groningen
2022
University of Groningen
2022
Erasmus MC - Sophia Children’s Hospital
2016
Wilhelmina Children's Hospital
2016
Intrauterine growth retardation is associated with an increased risk of developing adult diseases, such as noninsulin-dependent diabetes mellitus (NIDDM). NIDDM could result from a decreased insulin sensitivity or reduced secretion combination both. Glucose tolerance, sensitivity, and were studied in prepubertal children born small for gestational age (SGA). Twenty-nine SGA mean 9.1 +/- 1.1 yr 24 appropriate (AGA), 9.0 yr, studied. All at term prepubertal. Children on two separate days after...
The KLIK method is an online tool that monitors and discusses electronic patient-reported outcomes (ePROs), which has been shown to enhance outcomes. This study aimed (1) determine the fidelity (ie, extent used as intended) of implemented in outpatient pediatric cancer care (2) health professional (HCP)-reported barriers facilitators for implementation.Two hundred five children with newly diagnosed (enrollment rate 85%) participated. At 1 (T1), 3 (T2), 6 (T3) months after diagnosis, patients...
Abstract Purpose Cancer‐related fatigue is one of the most distressing side effects childhood cancer treatment. Physical activity can decrease and has positive on other health outcomes. Most research physical pertains to adults, few studies that focus children have limited follow‐up time. This study evaluates cancer‐related in its association with over a one‐year time period. Methods Sixty‐eight (7–18 years) were recruited during or within first year after (Actical monitor) (Pediatric...
Childhood cancer survivors face late health problems; despite advances in research, details on risk remain unclear. We describe the methodological aspects of Dutch Cancer Survivor Study (DCCSS) cross-sectional clinical study (LATER 2 study).From multi-center DCCSS LATER cohort 6165 five-year diagnosed during 1963-2001, we invited 4735 eligible 2016, as well siblings and parents survivors. Gaps evidence identified development surveillance guidelines were translated into research questions for...
The ALL10 protocol improved outcomes for children with ALL by stratifying and adapting therapy into three minimal residual disease-defined risk groups: standard risk, medium (MR), high risk. IKZF1-deleted (IKZF1del) in the largest MR group still showed poor outcome, line protocols worldwide, accounting a number of overall relapses. toxicity Down syndrome (DS) excellent outcome ETV6::RUNX1 ALL. Poor prednisone responders (PPRs) were treated as ALL10. In ALL11, we prolonged IKZF1del from 2 to...
This study assessed cardiorespiratory fitness (CRF), physical activity (PA), and sedentary behavior (SB), as well factors associated with these outcomes in children during or shortly after cancer treatment. Cross-sectionally, CRF data, obtained by the cardiopulmonary exercise test, PA SB an accelerometer, were (8–18 years old). Linear regression models used to determine associations between CRF, PA, patient characteristics. Among 60 cancer, mean age 12.6 years, 35 boys, 28 % reported z score...
Abstract Background Long‐term survivors of acute lymphoblastic leukemia (ALL) in childhood are at increased risk late effects cancer treatment, among which cardiovascular sequelae. Purpose this study was to assess blood pressure and body composition ALL compare data reference values from the general population. Procedure This single‐center retrospective included 68 with a median age 25 years (range 16.4–39.5) follow‐up 16.0 5.3–30.4). Data on previous measurements weight height diagnosis...
Purpose Dexamethasone is a key component in the treatment of pediatric acute lymphoblastic leukemia (ALL), but can induce serious adverse effects. Recent studies have led to hypothesis that neuropsychological effects may be result cortisol depletion cerebral mineralocorticoid receptors. We examined whether including physiologic dose hydrocortisone dexamethasone reduce neuropsychologic and metabolic children with ALL. Patients Methods performed multicenter, double-blind, randomized controlled...
Physical fitness and psychosocial function is often reduced in children during or shortly after cancer treatment. This study evaluates the effect of a combined physical exercise intervention on cardiorespiratory fitness, muscle strength, body composition, health-related quality life (HrQoL). In addition, mediators, applicability adherence were examined. multicenter randomized controlled trial included 68 with [mean age 13.2 (SD: 3.1) years; 54% male] treatment within 12-months...
Abstract Objective Although survival rates in childhood cancer have improved, prevention and reduction of late effects remain important. This study evaluates the a combined physical exercise psychosocial intervention on health‐related quality life (HrQoL) functioning patients. Methods In this multicenter randomized controlled trial, patients (aged 8–18 years) their parents filled questionnaires HrQoL, depressive symptoms, behavioral problems, self‐esteem. Measurements were conducted at...
Data on the long-term effects of prenatal exposure to maternal cancer and its treatment child development are scarce.In a multicenter cohort study, neurologic cardiac outcomes 6-year-old children born women diagnosed with during pregnancy were compared outcome after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography echocardiography.In total, 132 study controls included. In group, 97 (73.5%) prenatally exposed...
The primary objective of this randomized study was to determine whether a continuous dosing schedule (without the asparaginase-free interval) would result in less hypersensitivity reactions PEGasparaginase (PEGasp) compared with standard noncontinuous schedule.
Childhood cancer and its treatment have considerable impact on a child's physical mental wellbeing. Especially long-term administration of chemotherapy and/or radiotherapy impairs fitness both during after therapy, when children often present with muscle weakness low cardiorespiratory fitness. Physical exercise can improve these two elements fitness, but the positive effects might be further increased wellbeing is simultaneously enhanced by psychosocial training. Feeling better may increase...
Insulin secretion and sensitivity was studied in 28 prepubertal children born small for gestational age (SGA) 22 appropriate (AGA). The effect of body size during childhood also assessed. measured using the hyperinsulinemic-euglycemic clamp (M value), β-cell function with hyperglycemic plus arginine. First-phase insulin response (FIR) used to calculate disposition index (FIR × M value). Arginine-stimulated second-phase as a measure capacity. ΔBMI0–1 year, ΔBMI0–2 years, ΔBMI2–9 years were...
Reduced fetal growth appears to be associated with precocious adrenarche, early puberty and polycystic ovary syndrome subsequent fertility problems. We investigated pubertal development DHEAS levels in children born small for gestational age (SGA) appropriate (AGA). Physical examination was carried out twice. Mean (+/-SD) at the first visit: SGA group, 9.1+/-1.1 yr; AGA 9.0+/-1.1 yr. AT FOLLOW-UP: 11.6+/-1.0 11.6 +/-1.1 Pubertal stages of were assessed. Pubic hair recorded as a measure...