A5054274181- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Breast Implant and Reconstruction
- Radiomics and Machine Learning in Medical Imaging
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Endometrial and Cervical Cancer Treatments
- MRI in cancer diagnosis
- Cervical Cancer and HPV Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Ultrasound and Hyperthermia Applications
- Orthopedic Infections and Treatments
- Nutrition and Health in Aging
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Metabolism, Diabetes, and Cancer
University Medical Center Utrecht
2016-2025
Utrecht University
2007-2025
Heidelberg University
2007-2020
University Hospital Heidelberg
2007-2020
Wilhelmina Children's Hospital
2014-2015
University Medical Center
2007-2011
University of Groningen
2007
Routine removal of the internal mammary chain (IMC) sentinel node in breast cancer patients remains a subject discussion. The aim this study was to determine impact routinely performed IMC biopsy on systemic and locoregional treatments plan. All with proven who underwent procedure between 2002 2011 were included prospective database. In cases drainage, successful exploration (i.e., removed) surgical complications registered. If removed contained malignant cells we determined if altered...
18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) is frequently used to diagnose fracture-related infections (FRIs), but its diagnostic performance in this field still unknown. The aims of study were: (1) assess the qualitative assessment 18F-FDG PET/CT scans diagnosing FRI, (2) establish standardized uptake values (SUVs) extracted from and determine their associated optimal cut-off values, (3) identify variables that predict a false-positive (FP) or false-negative (FN)...
A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial irradiation (APBI) an alternative whole following breast-conserving surgery. MRI-guided single dose ablative APBI has the potential to offer a minimally burdening, non-invasive treatment that could replace current therapy. The ABLATIVE study prospective, arm, multicenter evaluating preoperative, dose, radiation in...
Sentinel lymph node (SLN) biopsy has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). [99mTc]Tc-tilmanocept may be of benefit OSCC with complex lymphatic drainage patterns and close spatial relation SLNs.A prospective within-patient evaluation study was designed compare [99mTc]Tc-nanocolloid for SLN detection. A total 20 patients were included, who underwent lymphoscintigraphy both tracers. Both lymphoscintigraphic images each patient...
To study additional benefits of performing Tc-99m dimercaptosuccinic acid (Tc-99m-DMSA) scintigraphy as part the follow-up adults with spinal dysraphism (SD), compared ultrasonography, regard to finding renal scarring and difference in split function.Between January 2011 April 2013 every patient visiting our specialized outpatient clinic for SD was invited undergo both ultrasonography Tc-99m-DMSA scintigraphy. Outcomes modalities were compared, focus on scarring. The relation between...
Our purpose was to prospectively investigate optimal evaluation of qualitative and quantitative <sup>18</sup>F-FDG PET/CT in response evaluations 12–14 wk after neoadjuvant chemoradiotherapy (nCRT) esophageal cancer patients. <b>Methods:</b> This a side study the prospective diagnostic pre-SANO trial. scans at baseline nCRT were qualitatively assessed for presence tumor. Maximum SUVs normalized lean body mass (SUL<sub>max</sub>) measured all scans. The primary endpoint proportion...
Cardiac sarcoidosis (CS) is a multisystem granulomatous disorder of unknown etiology with frequent cardiac involvement. We describe patient presenting ventricular tachycardia, presumably originating in the right ventricle (RV). This had malignant clinical course initial diagnosis arrhythmogenic dysplasia/cardiomyopathy (ARVD/C); however, at postmortem histopathology revealed epithelioid granulomas fibrosis localized interventricular septum, typical for sarcoidosis, without signs extracardiac...
Wire guided localization (WGL) for non-palpable breast cancer is technically difficult and patient unfriendly. Radio occult lesion (ROLL) takes advantage of the possibility to detect tumor through nuclear tracer that injected directly into sentinel node procedure.Forty patients with 41 invasive carcinomas were treated using ROLL. Patients received a dose 120 Mbq 99mTc Nanocolloid intra-tumorally on day surgery or 370 Nanocolloïd prior day. The (SN) was located patent blue gamma ray detection...
Background: Diagnosing fracture-related infection (FRI) without clinical confirmatory signs is challenging. [18F]FDG-PET/CT has been shown to have good diagnostic accuracy. However, direct interpretation criteria are lacking. The aim of this study was assess the value increased FDG-uptake in locoregional lymph nodes on patients with suspected upper and lower extremity FRI. Methods: This a retrospective cohort who underwent for FRI two tertiary referral centers between January 2011 December...
The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel (SN) involvement is questionable. Accurate prediction of second echelon could identify those most likely to benefit from ALND.A consecutive series 317 a tumor positive SN followed by ALND was reviewed. Clinicopathologic features the primary were assessed as possible predictors involvement.Second metastases found 116/317 cases (36.6%). Frequency isolated cells (ITC,...
With the increasing number of non palpable breast carcinomas, need a good and reliable localization method increases. Currently wire guided (WGL) is standard care in most countries. Radio occult lesion (ROLL) new technique that may improve oncological outcome, cost effectiveness, patient comfort cosmetic outcome. However, studies published hitherto are poor quality providing less than convincing evidence to change current care. The aim this study compare ROLL with regarding percentage tumour...
Background Accurate evaluation of the spleen is an important component staging lymphoma, because this may have prognostic and therapeutic implications. Purpose To determine diagnostic value whole-body magnetic resonance imaging (MRI), including diffusion-weighted (whole-body MRI-DWI) in detection splenic involvement lymphoma. Material Methods This IRB approved, prospective multicenter study included a total 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 T...