A5054784845- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Metabolism and Genetic Disorders
- Polyomavirus and related diseases
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Eosinophilic Disorders and Syndromes
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
University Medical Center Freiburg
2015-2025
University of Freiburg
2016-2025
German Center for Pediatric and Adolescent Rheumatology
2017
Nagoya University
2000-2011
The Japanese Data Center for Hematopoietic Cell Transplantation
2008-2009
Japan Pediatric Society
2008
Obihiro National Hospital
2007
Centre Hospitalier Universitaire de Bordeaux
2006
Japanese Red Cross Nagoya Daiichi Hospital
2000
Hematopoietic stem cell transplantation (HSCT) requires significant infrastructure. Little is known about HSCT use and the factors associated with it on a global level.To determine current of to assess differences in its application explore associations macroeconomic transplant rates level.Retrospective survey study patients receiving allogeneic autologous HSCTs for 2006 collected by 1327 centers 71 participating countries Worldwide Network Blood Marrow Transplantation. The regional areas...
The classification of myelodysplastic syndromes is based on the morphological criteria proposed by French-American-British (FAB) and World Health Organization (WHO) groups. Accurate enumeration blast cells, although essential for diagnosis syndrome assignment to prognostic groups, often difficult, due imprecise definition blasts promyelocytes. An International Working Group Morphology Myelodysplastic Syndrome (IWGM-MDS) hematopathologists hematologists expert in field reviewed features bone...
Abstract Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling. Established clinical and genetic markers fail to fully recapitulate the biological heterogeneity this disease. Here we report DNA methylome analysis mutation profiling 167 JMML samples. We identify three subgroups with unique molecular characteristics. The high methylation group (HM) somatic PTPN11 poor outcome. low enriched for...
In the present study we evaluated feasibility of unrelated cord blood transplantation (UCBT) in patients with severe aplastic anemia (SAA). The outcome 31 SAA (median age 28; range: 0.9-72.3 years old) who received UCBT was analyzed. cumulative incidences neutrophil and platelet recovery after were 54.8 72.2%, respectively (95% confidence interval [CI] = 36.0%-70.3% 51.3%-85.3%, respectively). grade ≥II acute chronic graft-versus-host disease (aGVHD, cGVHD) 17.1% CI 6.2%-32.8%) 19.7%...
Dyskeratosis congenita (DC) is a genetic multisystem disorder with frequent involvement of the bone marrow. Haematopoietic stem cell transplantation (HSCT) only definitive cure to restore haematopoiesis, even though it cannot correct other organ dysfunctions. We collected data on outcome HSCT in largest cohort DC (n = 94) patients ever studied. Overall survival (OS) and event-free (EFS) at 3 years after were 66% 62%, respectively. Multivariate analysis showed better outcomes aged less than...
A total of 100 children under the age 17 years with acquired aplastic anaemia (AA) were initially treated immunosuppressive therapy (IST) (n = 63) or bone marrow transplantation (BMT) 37) from an HLA-matched family donor. The projected 10-year survival rates 55 +/- 8% and 97 3% respectively (P 0.004). Because IST group included 11 non-responders who salvaged by BMT unrelated donor, we compared failure-free (FFS) between groups. probability FFS at 10 was for group, 40 0.0001). Seven patients...
To characterize childhood acute megakaryoblastic leukaemia (AMKL), we reviewed 45 children with AMKL diagnosed between 1986 and 2005 at Nagoya University Hospital Japanese Red Cross First Hospital. Twenty-four patients (53%) had associated Down syndrome (DS-AMKL) 21 (47%) non-DS-AMKL. The median age of the DS-AMKL was months (range, 8-38 months) that non-DS-AMKL 15 2-185 months). morphology blast cells categorized into three groups according to stage megakaryocyte maturation. were more...
Highlights•Overall survival was better with bone marrow as graft source in sibling transplants for aplastic anemia.•Chronic graft-versus-host disease worse peripheral blood stem cells source.•In non–high-income countries, there no significant difference between the 2 sources.•Analysis of registry data should cater to variations outcomes different economic regions.AbstractBone (BM) is preferred hematopoietic cell transplantation (HSCT) severe anemia (SAA) compared mobilized (PBSCs). We...
The risk of acute graft-versus-host disease (GVHD) after HLA-matched sibling bone marrow transplantation (BMT) is lower in Japanese than Caucasian patients. However, race may have differential effect on GVHD dependent the graft source. North American and patients receiving their first allogeneic BMT or peripheral blood stem cell from an for leukemia were eligible. was performed 13% 53% On multivariate analysis, interaction term between source not significant any models, indicating that does...
Abstract GATA2 deficiency is a heterogeneous multi-system disorder characterized by high risk of developing myelodysplastic syndrome (MDS) and myeloid leukemia. We analyzed the outcome 65 patients reported to registry European Working Group (EWOG) MDS in childhood carrying germline mutation ( mut ) who had undergone hematopoietic stem cell transplantation (HSCT). At 5 years probability overall survival disease-free (DFS) was 75% 70%, respectively. Non-relapse mortality relapse equally...
Abstract Background Wiskott–Aldrich syndrome (WAS) is a rare X‐linked immunodeficiency caused by defects of the WAS protein ( WASP ) gene. Patients with typically demonstrate micro‐thrombocytopenia. Procedures The report describes seven male infants that initially presented leukocytosis, monocytosis, and myeloid erythroid precursors in peripheral blood (PB) dysplasia bone marrow (BM), which was indistinguishable from juvenile myelomonocytic leukaemia (JMML). Results median age affected...