A5085429434- Hematopoietic Stem Cell Transplantation
- Complement system in diseases
- Acute Myeloid Leukemia Research
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neutropenia and Cancer Infections
- Hemoglobinopathies and Related Disorders
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Renal Transplantation Outcomes and Treatments
- Hymenoptera taxonomy and phylogeny
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Fossil Insects in Amber
- Plant and animal studies
Hanyang University Seoul Hospital
2024-2025
Seoul St. Mary's Hospital
2015-2024
Catholic University of Korea
2015-2024
Yonsei University
2020-2024
Konyang University Hospital
2022
Aichi Medical University
2021
Lotte Fine Chemical (South Korea)
2020
Yeungnam University
2004-2018
Kyung Hee University
2006-2017
Pusan National University Hospital
2017
The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries individual centers. In 2016, 82,718 first HCT were reported 1,662 teams in 86 195 World Health Organization states representing a global increase 6.2% autologous 7.0% allogeneic bringing total to 1,298,897 procedures. Assuming frequency 84,000/year, 1.5 million performed 2019...
Despite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable curing these diseases. Allo-HCT has been also shown be curative in benign disorders such as aplastic anemia, sickle disease, and thalassemia, among others. Recently, the American Society for Transplantation Cellular Therapy (ASTCT) published standardized definitions recovery, graft rejection, failure, poor function,...
Abstract HLA-haploidentical hematopoietic cell transplantation (Haplo-HCT) using posttransplantation cyclophosphamide (PT-Cy) has improved donor availability. However, a matched sibling (MSD) is still considered the optimal donor. Using Center for International Blood and Marrow Transplant Research database, we compared outcomes after Haplo-HCT vs MSD in patients with acute myeloid leukemia (AML) first complete remission (CR1). Data from 1205 adult CR1 AML (2008-2015) were analyzed. A total...
Eculizumab is first-line treatment for paroxysmal nocturnal hemoglobinuria (PNH); however, approximately 11%-27% of patients may experience breakthrough hemolysis (BTH) on approved doses eculizumab. Ravulizumab, a new long-acting C5 inhibitor with four-times longer mean half-life than eculizumab, provides immediate, complete, and sustained inhibition over 8-week dosing intervals. In two phase 3 studies, ravulizumab was noninferior to eculizumab (Pinf ≤0.0004) the BTH endpoint; fewer...
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes. Danicopan a first-in-class oral proximal, alternative pathway factor D inhibitor. Therapeutic inhibition was designed control prevent C3-mediated extravascular hemolysis. In this open-label, phase II, dose-finding trial, ten untreated PNH patients with received danicopan monotherapy (100-200 mg thrice...
Abstract The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes HCT approaches by donor adults with ALL in remission. primary objective was to compare overall survival (OS) among HCTs PTCy and HLA-matched sibling (MSD), 8/8 unrelated (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing MSD HCT,...
Abstract Objectives The complement component 5 (C5) inhibitor ravulizumab demonstrated non‐inferiority to eculizumab following 26 weeks of treatment in inhibitor‐naïve and inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH; studies 301 302, respectively). This study aims describe the results both from 27 2 years. Methods Patients ( N = 441) continued receive throughout extension period. Efficacy endpoints included lactate dehydrogenase (LDH) normalization,...
Bone marrow-derived mesenchymal stem cells (MSCs) can prevent various autoimmune diseases. We examined the therapeutic potential of transforming growth factor β (TGFβ)-transduced MSCs in experimental arthritis, using an accepted animal model collagen-induced arthritis (CIA).DBA/1J mice with CIA were treated syngeneic TGFβ-induced MSCs, whereas control received either vehicle or alone. Arthritis severity was assessed by clinical and histologic scoring. TGFβ-transduced tested for their...
What is the most effective treatment for early stages of osteonecrosis femoral head? We assessed multiple drilling and stem cell implantation to treat head. report clinical radiological results core decompression. In total, 128 patients (190 hips) who had undergone surgery were divided into two groups based on which they received: (1) or (2) decompression, curettage a bone graft. The radiographic compared. At 5-year follow-up, in group, 64.3% (27/42) with Stage IIa disease, 56.7% (21/37) IIb...
Hemophagocytic lymphohistiocytosis is an overwhelming systemic inflammatory process that life-threatening if not treated appropriately. We analyzed prognostic factors in patients with secondary hemophagocytic excluding malignancy. In this retrospective study, we 126 adult cases between 2001 and 2017. Treatment was based on dexamethasone or without etoposide cyclosporine. Patients who achieved a complete response by 4 weeks were defined as early stable responders, those failed to achieve but...
Extranodal NK/T-cell lymphoma (ENKTCL) is associated with latent Epstein-Barr virus (EBV) infection and frequent relapse even after complete response (CR) to intensive chemotherapy radiotherapy. The expression of EBV proteins in the tumor provides targets for adoptive immunotherapy antigen-specific cytotoxic T cells (CTL). To evaluate efficacy safety membrane protein (LMP)-1 LMP-2a-specific CTLs (LMP1/2a CTLs) stimulated LMP1/2a RNA-transferred dendritic cells, we treated 10 ENKTCL patients...
Predictive Factors of Mortality in Population Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results from a Korean PNH RegistryParoxysmal nocturnal hemoglobinuria (PNH) is progressive, systemic, life-threatening disease, characterized by chronic uncontrolled complement activation.A retrospective analysis 301 patients who had not received eculizumab was performed to systematically identify the clinical symptoms and signs predictive mortality.PNH hemolysis (lactate dehydrogenase...
Highlights•Broad-spectrum antibiotic use correlates with intestinal graft-versus-host diseases.•Broad-spectrum reduces bacterial diversity.•Loss of diversity affects the occurrence GVHD.•Broad-spectrum has effects on circulating immune cell recovery.ABSTRACTPatients undergoing hematopoietic stem transplantation (HSCT) frequently receive empiric antibiotics during neutropenic period before engraftment. Several recent studies have shown that anaerobes in intestine are important mediators...
Highlights•Overall survival was better with bone marrow as graft source in sibling transplants for aplastic anemia.•Chronic graft-versus-host disease worse peripheral blood stem cells source.•In non–high-income countries, there no significant difference between the 2 sources.•Analysis of registry data should cater to variations outcomes different economic regions.AbstractBone (BM) is preferred hematopoietic cell transplantation (HSCT) severe anemia (SAA) compared mobilized (PBSCs). We...