Kwang Woo Ahn
A5000705580- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Statistical Methods and Inference
- CAR-T cell therapy research
- Statistical Methods and Bayesian Inference
- Eosinophilic Disorders and Syndromes
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Statistical Methods in Clinical Trials
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Advanced Causal Inference Techniques
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- COVID-19 Impact on Reproduction
- Mesenchymal stem cell research
- T-cell and Retrovirus Studies
Medical College of Wisconsin
2016-2025
Milwaukee County Medical Complex
2024
Hudson Institute
2023
University of Nebraska Medical Center
2023
Walsall Healthcare NHS Trust
2021
National Hellenic Research Foundation
2021
Örebro University
2021
Chinese Academy of Sciences
2021
Center for Excellence in Molecular Cell Science
2021
University of Lübeck
2021
Sport-related concussion (SRC) is typically followed by clinical recovery within days, but reports of prolonged symptoms are common. We investigated the incidence in a large cohort (n = 18,531) athlete seasons over 10-year period. A total 570 athletes with (3.1%) and 166 controls who underwent pre-injury baseline assessments symptoms, neurocognitive functioning balance were re-assessed immediately, 3 hr, 1, 2, 3, 5, 7, 45 or 90 days after concussion. Concussed stratified into typical (within...
Related donor haploidentical hematopoietic cell transplantation (Haplo-HCT) using post-transplantation cyclophosphamide (PT-Cy) is increasingly used in patients lacking HLA-matched sibling donors (MSD). We compared outcomes after Haplo-HCT PT-Cy with MSD-HCT lymphoma, the Center for International Blood and Marrow Transplant Research registry.We evaluated 987 adult undergoing either (n = 180) or 807) following reduced-intensity conditioning regimens. The group received graft-versus-host...
We evaluated outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced-intensity conditioning (RIC). The median age at RIC HCT was 55 yr. Donors were a matched sibling donor (MSD) 34% of HCTs, an HLA well-matched unrelated (URD) 45%, partially matched/mismatched URD 21%. Risk stratification according to the Dynamic International Prognostic Scoring System (DIPSS) 12% low, 49%...
Summary For diffuse large B‐cell lymphoma ( DLBCL ) patients progressing after autologous haematopoietic cell transplantation (auto HCT ), allogeneic (allo is often considered, although limited information available to guide patient selection. Using the Center for International Blood and Marrow Transplant Research CIBMTR database, we identified 503 who underwent allo disease progression/relapse following a prior auto . The 3‐year probabilities of non‐relapse mortality, progression/relapse,...
Highlights•Patients with follicular lymphoma (FL) experiencing early therapy failure (ETF) within 2 years of frontline chemoimmunotherapy have poor overall survival (OS).•FL patients ETF receiving autoHCT soon after treatment (≤1 year ETF; n = 123) had higher 5-year OS than those without (73% versus 60%).AbstractPatients (OS). We analyzed data from the Center for International Blood and Marrow Transplant Research (CIBMTR) National LymphoCare Study (NLCS) to determine whether autologous...
This study retrospectively compared long-term outcomes of nonmyeloablative/reduced intensity conditioning (NMC/RIC) allogeneic hematopoietic cell transplantation (allo-HCT) from a haploidentical family donor (haplo-HCT) using posttransplant cyclophosphamide (PTCy) with those matched sibling (MSD) and unrelated (MUD) or without T-cell depletion (TCD+/TCD-) in patients relapsed diffuse large B-cell lymphoma (DLBCL). Adult DLBCL who had undergone their first NMC/RIC allo-HCT between 2008 2015...
Over the past 2 decades, reduced-intensity conditioning allogeneic hematopoietic cell transplantation (RIC HCT) has increased substantially. Many patients do not have fully HLA-matched donors, and impact of HLA mismatch on RIC HCT been examined in large cohorts. We analyzed 2588 recipients 8/8 HLA-high resolution matched (n = 2025) or single-locus mismatched 563) unrelated donor (URD) from 1999 to 2011. Overall survival (OS) was primary outcome. Secondary endpoints included treatment-related...
Younger age has been hypothesized to be a risk factor for prolonged recovery after sport-related concussion, yet few studies have directly evaluated differences in acute recovery.Context: To compare clinical patterns high school and collegiate athletes.Objective: Prospective cohort study.Design: Large, multicenter prospective sample collected from 1999–2003 sports medicine setting.Setting: Concussed athletes (n = 621; 545 males 76 females) uninjured controls 150) participating contact...
Abstract Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without (non-HCT) (1377 was analyzed Cox proportional hazards model. Survival analysis stratified by Dynamic International Prognostic Scoring System (DIPSS) revealed that first year of treatment arm assignment, due to upfront risk transplant-related...
<h3>Importance</h3> Primary central nervous system lymphoma (PCNSL) requires induction and consolidation to achieve potential cure. High-dose therapy autologous hematopoietic cell transplant (AHCT) is an accepted effective strategy for PCNSL, but no consensus exists on the optimal conditioning regimens. <h3>Objective</h3> To assess outcomes in patients with PCNSL undergoing AHCT 3 most commonly used regimens: thiotepa/busulfan/cyclophosphamide (TBC), thiotepa/carmustine (TT-BCNU),...
Patients with chemorefractory mantle cell lymphoma (MCL) have a poor prognosis. We used the Center for International Blood and Marrow Transplant Research database to study outcome of 202 patients refractory MCL who underwent allogeneic hematopoietic transplantation (allo-HCT) using either myeloablative (MA) or reduced-intensity/nonmyeloablative conditioning (RIC/NST), during 1998-2010. analyzed nonrelapse mortality (NRM), progression/relapse, progression-free survival (PFS), overall (OS)....
Patients with chemorefractory non-Hodgkin lymphomas generally have a poor prognosis. We used the observational database of Center for International Blood and Marrow Transplant Research to study outcome 533 patients refractory diffuse large B cell lymphoma (DLBCL) or grade III follicular (FL-III) who underwent allogeneic hematopoietic transplantation (allo-HCT) using either myeloablative (MA; n = 307) reduced-intensity/nonmyeloablative conditioning (RIC/NST; 226) between 1998 2010. analyzed...
Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched [MMUD]) enable patients without a sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different sources. However, the risk and types of infections have not been compared Such information may influence choice particular source. We incidence bacterial, viral, fungal in 1781 adults with acute leukemia...
BACKGROUND Race/ethnicity remains an important barrier in clinical care. The authors investigated differences the receipt of autologous hematopoietic cell transplantation (AHCT) among patients with multiple myeloma (MM) and outcomes based on race/ethnicity United States. METHODS Center for International Blood Marrow Transplant Research database was used to identify 28,450 who underwent AHCT MM from 2008 through 2014. By using data National Cancer Institute's Surveillance, Epidemiology, End...
To develop a system prognostic of outcome in those undergoing allogeneic hematopoietic cell transplantation (allo HCT) for myelodysplastic syndrome (MDS).We examined 2,133 patients with MDS HLA-matched (n = 1,728) or -mismatched 405) allo HCT from 2000 to 2012. We used Cox multivariable model identify factors mortality training subset 1,151) the cohort. A weighted score using these was assigned remaining (validation cohort; n 577) as well HLA-mismatched HCT.Blood blasts greater than 3%...