A5034553302- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Blood transfusion and management
- Mesenchymal stem cell research
- Blood donation and transfusion practices
- Blood groups and transfusion
- Transplantation: Methods and Outcomes
- Chronic Myeloid Leukemia Treatments
- Polyomavirus and related diseases
- Organ Donation and Transplantation
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Pluripotent Stem Cells Research
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Hematological disorders and diagnostics
- CAR-T cell therapy research
- Vector-Borne Animal Diseases
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood disorders and treatments
Japanese Red Cross Society, Japan
2015-2024
The University of Tokyo
1998-2020
Dartmouth–Hitchcock Medical Center
2018
Tokyo Metropolitan Komagome Hospital
2016
Mitsubishi Chemical (Japan)
2014
Japanese Red Cross Medical Center
1998-2013
Kyushu University
1991-2012
Tottori University
2011
National Sagamihara Hospital
2011
The Japanese Data Center for Hematopoietic Cell Transplantation
2007
A case of transfusion‐associated graft‐versus‐host disease (TA‐GVHD) in a patient with non‐Hodgkin's lymphoma is reported. The patient, 67‐year‐old woman, was diagnosed as having diffuse, mixed type lymphoma, at clinical stage IMA. She treated combination chemotherapy and received multiple blood transfusions for anemia thrombocytopenia. Although white cells (WBCs) were reduced the transfused components by WBC‐reduction filters, developed TA‐GVHD that confirmed skin biopsy. It suggested WBC...
We determined the prevalence of macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium DNA specimens from men with non-gonococcal urethritis (NGU) analysed their effects on antibiotic treatments M. infections. In this retrospective study, we examined 23S rRNA, gyrA parC genes association microbiological outcomes genitalium-positive NGU. No rRNA gene were observed 27 2011 24 2012. However, 5 17 2013 had mutations. Three 15 2011, 6 19 2012 8 alterations ParC....
Recent advances in unrelated cord blood transplantation have increased chances and options available allogeneic stem cell transplantation. The effect of HLA disparity on outcomes after was studied recently mainly pediatric populations. Results showed that matching combination with total nucleated dose positively affects survival. single-unit may be different adults because their is much lower compared to patients. We investigated the outcome separately 498 children aged 15 years or under...
Ex vivo expansion of hematopoietic stem cells (HSCs) has been explored in the fields cell biology, gene therapy, and clinical transplantation. Here, we demonstrate efficient ex HSCs measured by long‐term severe combined immunodeficient (SCID) repopulating (SRCs) from human cord blood CD133‐sorted using a soluble form Delta1. After 3‐week culture on immobilized Delta1 supplemented with factor, thrombopoietin, Flt‐3 ligand, interleukin (IL)‐3, IL‐6/soluble IL‐6 receptor chimeric protein (FP6)...
Recent advances in unrelated cord blood transplantation (UCBT) and high-resolution typing of human leukocyte antigen (HLA) from an donor have increased choices alternative donor/stem cell source selection. We assessed HLA-mismatched locus-specific comparison the outcomes 351 single-unit UCB 1,028 bone marrow (UBM) adult recipients 16 years old or older at time who received first stem with myeloablative conditioning for acute leukemia myelodysplastic syndromes. With adjusted analyses, HLA 0...
Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine models, natural killer (NK) cell responses have been shown to play crucial role in the pathogenesis cerebral malaria. To investigate NK cells developmental process human we conducted case-control study examining genotypes for immunoglobulin-like receptors (KIR) their leukocyte antigen (HLA) class I ligands 477 patients. We found that combination KIR2DL3 its...
BACKGROUND As patient blood management becomes more widespread, fewer red cell (RBC) units have been transfused. This multinational study evaluated changes in center RBC distributions. STUDY DESIGN AND METHODS Data on number and ABO D groups of distributions were obtained from several large American centers national or provincial services (NPBS) fiscal year (FY) 2010 through FY2014. Due to relatively larger numbers differences between the Japanese Red Cross other NPBS, data not included...
Abstract The major limitation of cord blood transplantation (CBT) for adults remains the delayed hematopoietic recovery and higher incidence graft failure, which result in a risk early mortality CBT. We evaluated overall survival (OS), non‐relapse (NRM), neutrophil engraftment, acute graft‐vs‐host disease, cause death among 9678 adult patients who received single‐unit CBT Japan between 1998 2017. probability OS at 100 days was 64.4%, 71.7%, 78.9% periods to 2007, 2008 2012, 2013 2017,...
Culture-derived mesenchymal stromal cells (MSCs) exhibit variable characteristics when manufactured using different methods and source materials. The purpose of this study was to assess the impact on MSC laboratories propagated MSCs from cultures initiated with BM aliquots derived same donor material.Five each three donors were distributed five independent laboratories. Three plated whole two a mononuclear cell fraction. Four cultured in media supplemented fetal bovine serum (FBS) one...
A risk assessment model for predicting the of haemolytic disease fetus and newborn (HDFN) in future pregnancies following transfusion Rh(D)-positive red blood cell (RBC)-containing products to females childbearing potential (FCP) was developed, accounting age that FCP is transfused various countries.The HDFN prediction included inputs: death trauma, Rh(D) alloimmunization rate RBC transfusion, expected number live births resuscitation, probability carrying an fetus, carried by alloimmunized...
summary Recently, evidence implicating the roles of anti‐human leucocyte antigen (HLA) class II antibody in development transfusion‐related acute lung injury (TRALI), which is one most serious possible side effects transfusion, has been accumulating. The aim this study to clarify anti‐HLA DR alloantibody TRALI development. Cultured human microvascular endothelial (LME) cells were incubated with either HLA‐DR15‐positive or HLA‐DR15‐negative monocytes together serum from a single multiparous...
The impact of the direction HLA mismatch (MM) on outcome in unrelated cord blood (UCB) transplantation has not yet been clarified. We conducted a retrospective study using national registry data 2977 patients who underwent single UCB for leukemia or myelodysplastic syndrome. matching was assessed by serologic HLA-A, -B, and -DR loci. median age recipients at 41 years (range, 0-82 years), 2300 (77%) were ≥16 years. 2-year overall survival rate 0.46. presence MM only graft-versus-host...