A5101523793- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Parvovirus B19 Infection Studies
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Cancer therapeutics and mechanisms
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
New York University
2025
ETH Zurich
2024
University of Zurich
2024
Medical University of Graz
2014-2023
Genomics (United Kingdom)
2023
Graz University Hospital
1997-2018
University of Graz
1997-2014
Universitätsklinik für Kinder und Jugendpsychiatrie
2005-2013
Umeå University
2009
Universidad de Las Palmas de Gran Canaria
2009
The European Nutrition and Health Report is the first comprehensive assessment of present status nutrition health in Europe, available resources requirements for compatible representative data from different countries. 13 EU member states Norway have participated this project, pursuing three main goals: Compila
Summary Transplantation of T ‐ and B ‐cell depleted allografts from haploidentical family donors was evaluated within a prospective phase II trial in children with acute lymphoblastic leukaemia, myeloid leukaemia advanced myelodysplastic syndrome ( n = 46). 20 patients had active disease; 19 received second or third stem cell transplantation SCT ). Toxicity‐reduced conditioning regimens consisted fludarabine clofarabine (in disease only), thiotepa, melphalan serotherapy. Graft manipulation...
Immune checkpoint inhibitors are standard-of-care for the treatment of advanced melanoma, but their use is limited by immune-related adverse events. Proteomic analyses and multiplex cytokine chemokine assays from serum at baseline event onset indicated aberrant T cell activity with differential expression type I III immune signatures. This was in line finding an increase proportion CD4+ cells IL-17A peripheral blood using flow cytometry. Multiplex immunohistochemistry spatial transcriptomics...
Urinary catecholamine metabolites are well-known to be elevated in patients with neuroblastoma. Some investigators have described different patterns favorable and unfavorable cases. However, extended studies not been published.We investigated urinary their correlation stage, biological features, outcome 114 consecutively clinically diagnosed neuroblastoma patients.Sensitivity of vanillylmandelic acid (VMA), homovanillic (HVA), dopamine (DA) was 80.7, 71.9, 61.3%, respectively. In 91.2% at...
Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological laboratory data from patients with M-HLH treated at our department between 1995 2014. Out 1.706 haemato-/oncologic 2014, we identified 22 (1.29%) (1.3–18.0, median 10.1 years; malignancy induced n = 2; chemotherapy...
Abstract Purpose: To identify better risk stratification systems in childhood medulloblastoma based on clinical factors and analysis of routinely processed formalin-fixed tumor material. Experimental Design: Formalin-fixed paraffin-embedded samples from well-documented patients treated within the prospective randomized multicenter trial HIT'91 were analyzed for DNA amplification c-myc N-myc (n = 133) mRNA expression trkC 104; compared with human cerebellum) using validated methods...
Object Reports on spinal cord ependymoma in children are rare. The aim of this study was to evaluate the clinical spectrum, treatment, and outcome with primary who were registered database pediatric German brain tumor studies Hirntumor (HIT) '91 HIT 2000. Methods Between 1991 2007, 29 patients (12 male 17 female, median age at diagnosis 13.6 years) (myxopapillary WHO Grade I, II, III tumors 6, 17, 6 patients, respectively) identified. Four had neurofibromatosis Type 2. Results With a...
Treatment of metastatic neuroblastoma (NB) demands aggressive oncological therapy, which may cause long-term sequelae in survivors. The aim this retrospective single center study is to give an overview survival children with stage 4 NB and describe the spectrum late effects seen survivors.Medical records 31 patients treated between 1984 2009, who were included a follow-up programme, reviewed for information on tumor, treatment effects.Five-year overall was 54.3 ± 9% 5-year event-free 44.9...
Chronic hepatitis C is a major long-term problem for children who survive cancer. Interferon (IFN)-alpha has been shown to be effective in treating patients with chronic C; however, the rate of sustained response low. Combining IFN-alpha and ribavirin (RBV) significantly improve adult C. The aim this pilot study was evaluate efficacy safety combined virostatic treatment RBV small cohort adolescents previous malignancy.Twelve history hematooncologic disease (median follow-up: 13.5 years;...
Hemophagocytic lymphohistiocytosis (HLH) during childhood cancer treatment is a rare adverse event posing major diagnostic and therapeutic challenges. Between 1995 2006, 6 children developed HLH while on conventional chemotherapy (n=4) or after allogeneic stem cell transplantation (n=2). Treatment of included dexamethasone etoposide, 2 additionally received infliximab daclizumab. Three survived, whereas 3 died 2, 5, 47 days diagnosis HLH. severe therapy. Early immediate initiation adequate...
Abstract Background Permanent supportive housing (PSH) is the gold standard intervention for chronic homelessness, but PSH tenants face high risk overdose due to a combination of individual and environmental factors. Little research has examined prevention in PSH. Methods We conducted baseline surveys with staff from 20 New York buildings participating an technical assistance study. were invited via email complete brief online survey about their knowledge perspectives on implementing...