A5088425375- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Full-Duplex Wireless Communications
- Virus-based gene therapy research
- Renal Transplantation Outcomes and Treatments
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Education Pedagogy and Practices
- Organ Transplantation Techniques and Outcomes
- Parvovirus B19 Infection Studies
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Histiocytic Disorders and Treatments
- Science and Education Research
- Transplantation: Methods and Outcomes
- Acute Myeloid Leukemia Research
- Antenna Design and Analysis
- Multiple Myeloma Research and Treatments
- Organ Donation and Transplantation
- Cancer Immunotherapy and Biomarkers
- Linguistics and Education Research
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Policlinico San Matteo Fondazione
2013-2024
Universidade Estadual Paulista (Unesp)
2012-2019
Palmetto Hematology Oncology
2016
University of Pavia
2001-2013
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2005
Ospedale Policlinico San Martino
2004
Policlinico S.Orsola-Malpighi
2003
University of Bologna
2003
Azienda Ospedaliero Universitaria Ospedali Riuniti
2002
Purpose Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) –related malignancy expressing EBV antigens that are possible targets of cell therapy, including latent membrane protein 2 (LMP2). We conducted a clinical trial EBV-targeted therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments. Patients and Methods Ten patients EBV-related stage IV in progression after radiotherapy chemotherapy received intravenously...
Polyoma BK virus (BKV)-associated nephropathy (PVAN) is a relevant cause of poor renal allograft survival. In prospective analysis, we monitored BKV DNA in blood and urine samples from 62 consecutive pediatric kidney recipients. patients with replication, analyzed the impact reduction maintenance immunosuppression on viral load kinetics PVAN replication. BKV-specific immunity was concomitantly evaluated viremic patients, by measuring frequency interferon-gamma-producing cytotoxic T cells,...
The treatment of Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disease (PTLD) after hematopoietic stem cell transplantation (HSCT) is still unsatisfactory. We conducted a prospective trial to evaluate the impact routine EBV surveillance and preemptive with anti-CD20 monoclonal antibody rituximab on development PTLD in pediatric recipients extensively T-cell depleted HSCT from an HLA-haploidentical relative. Twenty-seven patients were included program, 12 developed DNA...
The treatment of EBV-associated post-transplant lymphoproliferative disease (PTLD) poses a considerable challenge. Efforts have been made to define regimens based on combination the available therapeutic agents, chosen and tailored patient-by-patient basis, with aim augmenting event-free patient graft survival. Recently, autologous EBV-specific cytotoxic T-lymphocytes (CTL) proved effective in enhancing immune responses reducing viral load organ transplant recipients active infection. We...
Objective Progressive multifocal leukoencephalopathy (PML) is still burdened by high mortality in a subset of patients, such as those affected hematological malignancies. The aim this study was to analyze the safety and carry out preliminary evaluation efficacy polyomavirus JC (JCPyV)‐specific T cell therapy cohort patients with PML. Methods Between 2014 2019, 9 diagnosis “definite PML” according 2013 consensus who were showing progressive clinical deterioration received JCPyV‐specific...
Failure to mount or maintain a protective immune response may influence the development of polyomavirus BK (BKV)-associated nephropathy (PVAN). However, limited data are so far available on BKV-specific immunity after kidney transplantation. cellular was retrospectively analyzed in recipients with without BKV infection/reactivation by measuring frequency interferon (IFN)–γ-secreting cells peripheral blood. Patients BKV-active infection and good renal function (n=6) had mean lymphocyte 2 log...
Significance We report the discovery of complete human interleukin-1 receptor (IL-1R)-associated kinase 1 (IRAK-1) deficiency resulting from a de novo Xq28 microdeletion encompassing MECP2 and IRAK1 in boy. Like many boys with defects, this patient died very early. IRAK-1 is component Toll-like (TLR)/IL-1R (TIR) signaling pathway. Unlike patients autosomal-recessive MyD88 or IRAK-4, two other components TIR pathway, presented no invasive bacterial infections. analyzed impact fibroblasts...
Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying clinical association between air pollution, namely exposure particulate matter 10 (PM10), and inflammatory activity sclerosis (MS) METHODS: Daily recording PM10 obtained by monitors depending on residence subjects. Expression molecules involved in activation, adhesion, migration T lymphocytes were tested flow cytometry 57 MS patients...
ABSTRACT. Polyoma BK virus (BKV)-associated interstitial nephritis has emerged as a relevant complication of immunocompromise after kidney transplantation, leading to reduced survival the renal allograft. The limitations current antiviral treatment and high probability rejection in graft recipients when control viral replication is attempted by reduction immunosuppression warrant further efforts develop alternative therapeutic tools. Cellular immunotherapy proved be successful approach for...
Human adenovirus (HAdV) infection may cause life-threatening complications in recipients of hematopoietic stem cell transplantation (HSCT), the highest risk being observed children given T-cell depleted haploidentical allografts. The effectiveness pharmacologic therapy for HAdV is suboptimal. Recently, was demonstrated to offer a unique opportunity restore antiviral immune surveillance, leading clearance and prevention/treatment disease. However, infusion insufficiently selected...
Nucleophosmin(NPM1)-mutated protein, a leukemia-specific antigen, represents an ideal target for AML immunotherapy. We investigated the dynamics of NPM1-mutated-specific T cells on PB and BM samples, collected from 31 adult NPM1-mutated patients throughout disease course, stimulated with mixtures 18 short long peptides (9-18mers), deriving complete C-terminal protein. Two 9-mer peptides, namely LAVEEVSLR AVEEVSLRK (13.9-14.9), were identified as most immunogenic epitopes. IFNγ-producing...
SECTION 1: ORGAN, TISSUE, AND CELL VIGILANCE IN ITALY Alessandro Nanni Costa, and Deirdre Fehily As the regulation of organ, tissue, cell donation transplantation has developed in European Union, Italian Transplant Network, coordinated by National Centre (CNT), led implementation legislative requirements Italy, focusing efforts on ensuring safety from moment donor identification to clinical follow-up recipients. The legal framework covers substances human origin comprises a series...
Among the novel biologic therapeutics that will increase our ability to cure human cancer in years come, T cell therapy is one of most promising approaches. However, with possible exception tumor-infiltrating lymphocytes for melanoma, clinical trials adoptive T-cell solid tumors have so far provided only clear proofs-of-principle build on further development. Epstein-Barr virus (EBV)-associated malignancies offer a unique model develop cell-based immune therapies, targeting viral antigens...
Donor-specific HLA antibody (DSA)-mediated graft injury is the major cause of kidney loss. Among DSA characteristics, homing has been suggested as an indicator severe tissue damage. We analyzed role de novo (dnDSA) on transplantation outcome. Graft biopsy specimens and parallel sera from 48 nonsensitized pediatric recipients were analyzed. Serum samples eluates tested for presence dnDSAs with flow bead technology. Intragraft (gDSAs) never detected in absence serum (sDSAs), whereas sDSAs,...
De novo posttransplant donor-specific HLA-antibody ( dn DSA) detection is now recognized as a tool to identify patients at risk for antibody-mediated rejection (AMR) and graft loss. It still unclear whether the time interval from transplant DSA occurrence influences damage. Utilizing sera collected longitudinally, we evaluated 114 consecutive primary pediatric kidney recipients grafted between 2002 2013 by Luminex platform. DSAs occurred in 39 median of 24.6 months. In 15 patients, developed...