A5087296098- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Liver Diseases and Immunity
- Viral gastroenteritis research and epidemiology
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Drug-Induced Hepatotoxicity and Protection
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- HIV Research and Treatment
University of Modena and Reggio Emilia
2024
University of Bologna
2012-2023
Policlinico S.Orsola-Malpighi
2005-2017
Azienda USL di Bologna
2017
Ospedale Maggiore
2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017
Addiction Switzerland
2013
Medica (Italy)
2012
Cambridge University Press
2011
New York University Press
2011
Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide. Six-month imaging along with alpha-fetoprotein (AFP) serum levels detection are current gold standard to exclude HCC. Protein induced by vitamin K absence (PIVKA-II) has been proposed as a potential screening biomarker for This study was designed evaluate role PIVKA-II diagnostic HCC marker, and correlation between stage. were assessed on samples Italian patients. The population included 80...
Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus-specific T-cell responses linked with their potential to control infection. We took advantage of segregation different hepatitis B virus (HBV) genotypes in geographically genetically distinct host populations directly analyze impact variables exert on these parameters. against entire HBV proteome were analyzed a total 109 HBV-infected subjects ethnicities (47 Chinese origin 62 Caucasian...
Abstract Background & Aims Despite the excellent efficacy of direct‐acting antivirals ( DAA ) reported in clinical trials, virological failures can occur, often associated with development resistance‐associated substitutions RAS s). This study aimed to characterize presence clinically relevant s all classes real‐life failures. Methods Of 200 that were analyzed 197 ‐treated patients, 89 pegylated‐interferon+ribavirin (Peg IFN + RBV and 111 without HCV ‐1a/1b/1g/2/3/4=58/83/1/6/24/25;...
Introduction. Host lipid metabolism influences viral replication and lifecycle of hepatitis C virus. Our aim was to evaluate changes in glucose patients with chronic after therapy direct acting antivirals (DAA). Material methods. We considered consecutively treated between January November 2015 recording clinical data at baseline week 24 follow-up. Frozen serum samples were used for apolipoprotein A1 (apoA1), B (apoB) lipoprotein (a) [Lp(a)]. Wilcoxon test utilized estimate trends Logistic...
In animals, the bone marrow (BM) is a source of liver-repopulating cells with therapeutic potential in case tissue damage. However, early response human BM-derived stem (SC) to liver injury still unknown. Here, we studied 24 patients undergoing orthotopic transplantation (OLT) for end-stage disease or hepatocellularcarcinoma, and 13 submitted resection. The concentration circulating SC was determined by phenotypic analysis clonogenic assays. Moreover, assessed serum level inflammatory...
Summary. The relationship between the balance of helper T‐cell type 1 (Th1) or 2 (Th2) cytokines and clinical course hepatitis C virus (HCV) infection is unclear. We evaluated Th1 [interleukin (IL)‐2, interferon‐gamma (IFN‐ γ )] Th2 cytokine (IL‐4, IL‐10) 2,5‐oligoadenylate synthetase (OAS, an IFN‐induced antiviral protein) production by peripheral blood mononuclear cells from 10 healthy anti‐HCV‐positive individuals (group A), HCV‐RNA‐positive with persistently normal alanine...
The immune impairment characterizing chronic hepatitis B (cHBV) infection is thought to be the consequence of persistent exposure viral antigens. However, correlates different clinical stages cHBV and their relation with levels HBsAg have not been investigated. aim present study was evaluate relationship between HBV-specific T cells response degree in vivo HBV control serum HBeAg-HBeAb+ cHBV.Peripheral blood mononuclear from 42 patients profiles (treatment-suppressed, inactive carriers...
Selected populations of patients with chronic hepatitis B (CHB) may benefit from a combined use pegylated interferon-alpha (pegIFN-α) and nucleos(t)ides (NUCs). The aim our study was to assess the immunomodulatory effect pegIFN-α on T natural killer (NK) cell responses in NUC-suppressed identify cellular and/or serological parameters predict better cell-restoring control infection response for tailored application IFN-α add-on.
SECTION 1: ORGAN, TISSUE, AND CELL VIGILANCE IN ITALY Alessandro Nanni Costa, and Deirdre Fehily As the regulation of organ, tissue, cell donation transplantation has developed in European Union, Italian Transplant Network, coordinated by National Centre (CNT), led implementation legislative requirements Italy, focusing efforts on ensuring safety from moment donor identification to clinical follow-up recipients. The legal framework covers substances human origin comprises a series...
The assessment of cellular anti-viral immunity is often hampered by the limited availability adequate samples, especially when attempting simultaneous, high-resolution determination T cell responses against multiple viral infections. Thus, development assay systems, which optimize usage, while still allowing for detailed breadth and magnitude virus-specific cytotoxic lymphocyte (CTL) responses, urgently needed. This study provides an up-to-date listing currently known, well-defined CTL...
Summary. Serum hepatitis B virus surface antigen (HBsAg) levels have been suggested to predict interferon response in chronic B. A few data are available on the role of HBsAg measurement nucleos(t)ide analogues (NA) treatment. We retrospectively investigated relation between changes and main treatment outcomes during long-term lamivudine e (HBeAg)-negative total 42 HBeAg-negative patients were consecutively enrolled an open-label study monotherapy (150 mg/die). quantified every 6 months by...