A5061522368- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Glioma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Lung Cancer Research Studies
- Blood transfusion and management
- Renal and related cancers
- Bone Tumor Diagnosis and Treatments
- Prenatal Screening and Diagnostics
- Acute Lymphoblastic Leukemia research
- Erythropoietin and Anemia Treatment
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Management of metastatic bone disease
- Venous Thromboembolism Diagnosis and Management
- Blood donation and transfusion practices
- Hepatitis B Virus Studies
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Chemotherapy-related skin toxicity
Izmir University
2004-2022
Sağlık Bilimleri Üniversitesi
2022
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2003-2021
İzmir University of Economics
2020
İzmir Demokrasi Üniversitesi
2020
Creative Commons
2020
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2018
Izmir Kâtip Çelebi University
2016
Izmir Bozyaka Eğitim ve Araştırma Hastanesi
2013
Ankara Numune Eğitim ve Araştırma Hastanesi
2004
Yesilipek MA, Ertem M, Cetin Öniz H, Kansoy S, Tanyeli A, Anak Kurekci E, Hazar V. HLA‐matched family hematopoetic stem cell transplantation in children with beta thalassemia major: The experience of the Turkish Pediatric Bone Marrow Transplantation Group. Abstract: From January 1991 to June 2009, 245 major who underwent their first allogeneic HSCT Turkey and were followed for a minimum one yr post‐transplantation enrolled this study. median age patients was 6.6 old (range, 1–22 yr)....
The national protocol aimed to improve the outcome of high risk neuroblastoma patients by high-dose chemotherapy and stem cell rescue with intensive multimodal therapy.After 6 induction cycles, without disease progression were nonrandomly (by physicians' and/or parent's choices) allocated into two treatment arms, which designed continue conventional (CCT), or myeloablative therapy autologous (ASCR).Fifty-six percent (272 patients) was evaluated as risk. Response rate 71%. Overall event-free...
This study analyzes the data of thrombotic children who were followed up in different pediatric referral centers Turkey, to obtain more general on diagnosis, risk factors, management, and outcome thrombosis Turkish children. A simple two-page questionnaire was distributed among contact people from each center standardize collection. Thirteen responded invitation total number cases 271. All diagnosed with thromboembolic disease between January 1995 October 2001. Median age at time first event...
This multicentric study aimed to bring neuroblastoma patients together under IPOG-NBL-92 protocol and evaluate the results within period between 1992 2001 in Izmir. Sixty-seven from 4 pediatric oncology centers Izmir were included study. modified German Pediatric Oncology (GPO)-NB-90 was applied: Patients stage 1 received only surgery, while surgery plus chemotherapy courses (cisplatin, vincristine, ifosfamide) given 2 6 ifosfamide, epirubicin, cyclophosphamide) stages 3 patients. In who...
Pancreatoblastoma, rarely encountered in the literature, is a malignant exocrine tumor seen pancreas.A 5-year-old boy suffering from abdominal pain was sent to our institute for further examination and treatment.Clinical normal but palpable mass.Abdominal Doppler ultrasonography showed mass with well-defined margins within body of pancreas.Laboratory tests, including lactic dehydrogenase, alpha-fetoprotein cancer antigen 125 were abnormal.The invading splenic vein transverse colon removed...
This study aimed to define the status of juvenile myelomonocytic leukemia (JMML) patients in Turkey terms time diagnosis, clinical characteristics, mutational studies, course, and treatment strategies.Data including laboratory characteristics strategies JMML were collected retrospectively from pediatric hematology-oncology centers Turkey.Sixty-five children with diagnosed between 2002 2016 18 institutions throughout enrolled study. The median age at diagnosis was 17 months (min-max: 2-117...
AbstractThe authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) solid tumors (ST, 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly increased at 2nd 3rd months therapy (p < .05). At month, patients required less transfusion. dose 150 only three HM, but none ST patients, cell. However, after month epoetin U/kg....
This study evaluates the outcome of 66 pediatric patients with rrHL who underwent autoHSCT. Twenty-nine experienced early relapse, and 19 late relapse. Of 18 newly diagnosed HL, 13 were primary refractory disease five had responsive disease. At time transplantation, only 68% chemosensitive. The majority received BCNU + etoposide ara-C melphalan for conditioning (45/66), peripheral blood (56/66) was used as a source stem cells. After median follow-up period 39 months, 46 alive. yr,...
Purpose To evaluate the results of radiotherapy and prognostic factors affecting local control in nonextremity Ewing sarcomas. Methods Between 1995 2011, 44 patients with sarcomas were treated radiotherapy. Tumor localizations pelvis 23, spine 13, thoracic region 5, cranium 3 patients. size was ≥8 cm 56.8% Distant metastases present 19 at time diagnosis (43.1%). All 12 weeks neoadjuvant chemotherapy followed by surgery (45-54 Gy) or alone (54-64.8 Gy). Radiotherapy applied due to microscopic...
Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia in children.The objective this study was to evaluate presenting features, variation clinical courses, initial response rate therapy, and long-term outcome patients with ITP. Materials Methods: Three hundred fifty out 491 newly diagnosed ITP between diagnosis ages 6 months 16 years were included retrospective, descriptive study.Patients acute vs chronic ITP, recurrent compared terms age at...
We examined outcomes of 62 pediatric patients with relapsed or refractory non-Hodgkin lymphoma (rr-NHL) who underwent hematopoietic stem cell transplantation (HSCT). The overall survival (OS) and event-free (EFS) rates were 65% 48%, respectively. Survival for chemosensitive disease at the time HSCT significantly higher than those chemoresistant (69% vs. 37%, p = .019 OS; 54% 12%, < .001 EFS; respectively). A was only factor that predicted a limited OS (hazard ratio 10.00) EFS 16.39) rates....
The authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) solid tumors (ST, 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly increased at 2nd 3rd months therapy (p < .05). At month, patients required less transfusion. dose 150 only three HM, but none ST patients, cell. However, after month epoetin U/kg....
Divarcı E, Arslan S, Dökümcü Z, Kantar M, Demirağ B, Öniz H, Ertan Y, Alper Erdener A, Özcan C. Radiological nodule behavior: A critical parameter in the surgical management of pediatric pulmonary metastases. Turk J Pediatr 2018; 60: 372-379. behavior (RNB) means course appearance on consecutive CT scans. In this study, we aimed to discuss effects RNB prognosis patients with metastasis. Retrospective analysis who underwent metastasectomy (PM) between 2005-2015 was performed. RNBs were...
Objective:The prognostic factors and a new childhood index after autologous hematopoietic stem cell transplantation (AHSCT) in patients with relapsed/refractory Hodgkin's lymphoma (HL) were evaluated. Materials Methods:The of 61 who underwent AHSCT between January 1990 December 2014 evaluated.In addition, the Age-Adjusted International Prognostic Index Childhood (CIPI) evaluated for their impact on prognosis. Results:The median age was 14.8 years (minimummaximum: 5-20 years) at time...
This multicentric study aimed to bring neuroblastoma patients together under IPOG-NBL-92 protocol and evaluate the results within period between 1992 2001 in Izmir. Sixty-seven from 4 pediatric oncology centers Izmir were included study. modified German Pediatric Oncology (GPO)-NB-90 was applied: Patients stage 1 received only surgery, while surgery plus chemotherapy courses (cisplatin, vincristine, ifosfamide) given 2 6 ifosfamide, epirubicin, cyclophosphamide) stages 3 patients. In who...
Amaç: Hipoksiyle indüklenebilir faktör (HIF) 1 alfa (a) / beta (b) heterodimerik DNA bağlama kompleksidir ve anjiyogenez, glukoz/enerji metabolizması, hücresel büyüme, metastaz apoptoz gibi tümör progresyonuna bağlı genlerinin uyarılmasını içeren geniş transkripsiyonel yanıtı yönlendirir.HIF-1A'da kanser tedavisi için çekici bir hedef olarak ortaya çıkmıştır.Bu çalışmanın amacı, doku HIF-1A ekspresyonu, prognostik önemi Wilms tümörlerinin klinikopatolojik özellikleri arasındaki