A5053969226- Lymphoma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Ethics and Legal Issues in Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Histiocytic Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroblastoma Research and Treatments
- Chemotherapy-related skin toxicity
- Renal and related cancers
- Cancer therapeutics and mechanisms
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- CNS Lymphoma Diagnosis and Treatment
- Pharmaceutical studies and practices
- Hepatitis C virus research
- Medical Malpractice and Liability Issues
- Bacterial Identification and Susceptibility Testing
- Lymphadenopathy Diagnosis and Analysis
- Parvovirus B19 Infection Studies
- Platelet Disorders and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Blood disorders and treatments
- Neonatal Respiratory Health Research
Turkish Armed Forces
2004-2017
Military Medical Academy
1995-2009
Ankara University
2009
Hacettepe University
2000
The University of Texas at Austin
1999
Hacettepe University Hospital
1998
The histiocytoses are a heterogeneous group of disorders characterised by an excessive number histiocytes. In most cases the pathophysiology is unclear and treatment nonspecific. Faisalabad histiocytosis (FHC) (MIM 602782) has been classed as autosomal recessively inherited form with similarities to Rosai-Dorfman disease (RDD) (also known sinus massive lymphadenopathy (SHML)). To elucidate molecular basis FHC, we performed autozygosity mapping studies in large consanguineous family...
Methotrexate (Mtx) is an effective chemotherapeutic agent used in various cancer treatments. Gastrointestinal toxicity the drug's major limiting factor, arising mainly from oxidative damage. It has been proposed that ozone (O(3)) activator of antioxidant enzymes. Thus, this study was designed to investigate efficacy therapy prevention Mtx-induced intestinal injury rats. Twenty rats were allocated into three groups: sham, Mtx alone (untreated) and + O(3) (treated with ozone). Ozone...
Doxorubicin (DXR) is a chemotherapeutic agent used effectively in the treatment of several childhood malignancies. During treatment, cardiotoxicity caused by cell damage due to free oxygen radicals that are generated major limiting factor. This study was undertaken determine whether DXR-induced could be prevented natural foods with antioxidant properties such as aged garlic extract (AGEX), grape seed proanthocyanidin (PA), and hazelnut. Wistar albino male rats were assigned randomly 9 groups...
Cardiotoxicity, during or after therapy, is the most serious side effect of doxorubicin (DXR). The risk developing cardiac impairment increases concomitantly with an increase in cumulative dose DXR.The aim was to evaluate levels troponin-I (cTnI), brain natriuretic peptide (BNP) and endothelin-1 (ET-1) DXR induced injury.Thirty-nine Wistar albino rats were divided into three groups; a control group two-study groups that received low-dose (LDD) high-dose (HDD) weekly schedule for reaching...
Severe congenital neutropenia (SCN), also known as Kostmann syndrome, was originally reported an autosomal recessive disease of neutrophil production. The is characterized by a maturation arrest precursors at the promyelocytic stage differentiation and extremely low levels mature neutrophils in peripheral blood.A 6-year-old male presented with complaint gingival swelling bleeding, left side his face. Upon clinical examination, severe inflammation all tissues apparent, periapical abscess...
Doxorubicin (DXR), a highly effective chemotherapeutic agent, causes serious injury when extravasated. The can sometimes result in skin necrosis and ulceration, requiring surgery. detrimental effect of DXR on the antioxidant system via free oxygen radicals is one mechanisms proposed its etiology. Thus, we used melatonin, potent antioxidant, compared effects with dimethylsulfoxide (DMSO), which treatment patients DXR-induced extravasation. Twenty-seven Wistar-albino rats were used. After...
Ralstonia pickettii is an aerobic, gram-negative bacterium causing bacteremia following the use of contaminated saline vials, respiratory therapy solutions, skin disinfectants, blood culture mediums, and water supplies. It rarely associated with human infections. The authors report two cases R. in patients Port-A-Caths that could be treated only by removal ports.
It has recently been reported that the worldwide increase in number of pertussis cases is a result waning whole-cell vaccine-induced immunity. Thus, this study, we aimed to investigate immunity status primary and secondary school students district Ankara, Turkey. A total 997 healthy students, aged 9-17 years, who had immunized with four doses vaccine were included study. The subjects divided into two age groups: 9-14 15-17 years. To determine immune status, serum levels IgG anti-pertussis...
To examine children who present with enlargement of lymph nodes in terms demographic, clinical, serological and radiological aspects.Ninety-eight patients presented a complaint were examined aspects by screening file data retrospectively. The character (reactive, malign) was evaluated according to the distribution, number, sizes blood supply determined ultrasonographic measurements. Fisher's Exact test Mann-Whitney U Test used comparison groups. Kappa value assessment compatibility between...
Alpha fetoprotein (AFP) is generally used as a marker in diagnosis and follow-up of germ cell tumors hepatoblastomas. However, serum AFP levels were elevated our three patients with Wilms tumor. The could only be decreased completely by surgery not chemotherapy. Histopathologically, the consisted blastemal, stromal, epithelial cells. Chemotherapy was effective on stromal components tumors. In staining, source production identified blastemal tumor Because increased after surgery, may Herein,...
Journal Article Adrenomedullin worsens skin necrosis in rats subjected to vincristine‐induced extravasation Get access V. Kesik, Kesik Departments of Pediatric Oncology Dr Vural Department Oncology, Gulhane Military Medical Academy, School Medicine, Etlik, Ankara 06018, Turkey E‐mail: vural73@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar B. Kurt, Kurt Pathology T. Tunc, Tunc Pediatrics, Faculty, Ankara, Y. Karslioglu, Karslioglu E. C. Citak, Citak Kismet,...
Methotrexate is a folate antagonist that commonly used as an antitumor and antiarthritic drug. The aim of this study was to investigate the possible roles exogenous glutamine (Glu), arginine (Arg) proanthocyanidin (PA) on gut protection from methotrexate-induced intestinal damage in rats. Experimental rats were separated into eight groups. first (sham) group received 0.9% NaCl solution alone. second intraperitoneal injections methotrexate (20 mg/kg/day) administered day 4 experiment...
Abstract: TRALI is a rare and serious complication of blood product transfusion characterized by acute respiratory distress, non‐cardiogenic pulmonary edema, hypoxia, fever, hypotension developing during or up to six h following transfusion. The disease can be life‐threatening should considered whenever complications occur after in stem cell transplant recipients. Caution exercised as the symptoms are similar diseases such hemorrhage, engraftment syndrome. neutrophil generally occurs 14 days...
An 18-month-old boy presented with abdominal pain and distension. On physical examination there was a 10 × 7-cm mass in the right upper quadrant. His alpha-fetoprotein level 175,000 IU/mL. Abdominal magnetic resonance findings revealed hepatomegaly multiple tumor masses involving nearly all segments of liver (PRETEXT IV). The extended through inferior vena cava filled 2/3 atrium. Echocardiography normal cardiac function. Histopathologic after biopsy were consistent hepatoblastoma. After 6...