The aim of this study was to evaluate children with lymphadenopathy and clinical approach the suspicion malignancy. authors evaluated 457 patients peripheral lymphadenopathy, less than 19 years age, referred Pediatric Oncology Department Gazi University Medical School during periods March 1996-April 2004. A total 346 had benign disorders 111 malignant pathologies. Excisional biopsies were performed 134 patients. specific etiology could be found 39% in group. Of patients, 218 presented as...

Brucellosis continues to be an important cause of fever in underdeveloped countries and the rural areas developed world. It is a multisystemic disease, associated with wide variety symptoms. A symptoms, including hematologic abnormalities, such as anemia, thrombocytopenia, pancytopenia, dissemine intravascular coagulation, leucopenia could seen. The aim study review findings brucellosis childhood.In this short study, records 146 children were evaluated for manifestation retrospectively....

Abstract Background The goals of this study included: (1) Identification factors prognostic for event‐free survival (EFS) and overall (OS), (2) Definition risk groups adapted therapy in children with Hodgkin disease (HD). Procedure From 1991 to 2003, 69 newly diagnosed, untreated biopsy‐proven stage I–IV HD were treated chemotherapy (CT) low‐dose involved field radiotherapy (LD‐IFRT). relationship pretreatment EFS OS was analyzed by univariate multivariate analysis. Results 5‐year all...

Renal tumors are not uncommon in children. In this study, we aimed to evaluate the clinical and pathological features of renal children.Between January 2008 December 2017, records children with our institution were retrospectively analyzed. Data collected composed demographic characteristics including gender, age at time diagnosis, symptoms, laterality tumor evaluation.A total 48 (28 males 20 females) included study. They diagnosed mean 53.26±46.64 months (range: 1-192) follow-up period was...

Group A streptococcal infections cause a wide range of neuropsychiatric disorders, such as Sydenham's chorea, tics, obsessive-compulsive and pediatric autoimmune disorders associated with (PANDAS). Structural (computed tomography magnetic resonance imaging) functional (positron emission tomography, single-photon computed tomography) imaging studies in patients chorea have suggested reversible striatal abnormalities. The objective this study was to investigate the cerebral perfusion patterns...

Abstract Background The aim of our study was to evaluate the long‐term effects chemotherapy and/or radiotherapy on lung function in 75 childhood Hodgkin disease (HD) and non‐Hodgkin lymphoma (NHL) survivors several years after treatment. Patients Methods We studied 37 HD 38 NHL survivors. These patients were divided into two groups according treatment protocols applied. Group I consisted 23 who treated with both thoracic irradiation II 52 no irradiation. A detailed history smoking habits,...

A prospective, open-label, randomized, comparative study in pediatric cancer patients was conducted to evaluate the efficacy and safety of cefepime meropenem empiric therapy febrile neutropenic patients. Febrile episodes were classified as microbiologically documented infection, clinical or fever unknown origin. Clinical response success failure. In this period 37 children with solid tumors including lymphoma, 25 males, 12 females, had neutropenia on 65 occasions. Microbiologically...

Doxorubicin (DXR), a highly effective chemotherapeutic agent, causes serious injury when extravasated. The can sometimes result in skin necrosis and ulceration, requiring surgery. detrimental effect of DXR on the antioxidant system via free oxygen radicals is one mechanisms proposed its etiology. Thus, we used melatonin, potent antioxidant, compared effects with dimethylsulfoxide (DMSO), which treatment patients DXR-induced extravasation. Twenty-seven Wistar-albino rats were used. After...

The aim of this study was to evaluate and compare the clinical characteristics B-cell non-Hodgkin lymphoma (NHL) patients therapeutic efficacy modified NHL BFM-90 BFM-95 protocols in authors' center. From January 1993 December 2003, 61 newly diagnosed children with B-NHL were enrolled study. stratified by risk factors treated either a or protocols. use 1 3 g/m2 methotrexate instead 5 g/m2/24 h only important modification protocol. Sixty-one (12 girls, 49 boys) median age 6.5 years (range:...

The aim of this study was to compare the nephrotoxicity risk cisplatin (CPL) and ifosfamide (IFO) combination treatment (CT) with that CPL alone evaluate prevalence CPL-induced long-term in pediatric cancer survivors (CS).A total 33 patients solid tumors who have been cured their disease were included study. They divided into two groups based on type chemotherapeutics, either (n = 21) or CT 12), given during evaluated for glomerular tubular function using Skinner grading...

Cardiovascular complications and vascular changes are common in patients with beta-thalassaemia major. The aim of this study is to investigate the carotid artery intima-media thickness children.The population was consisted 33 thalassaemic children (22 boys 11 girls, a median age 8 years) 30 healthy for control (12 girls 18 boys, who were matched gender. Common measured.The patients' at diagnosis ranged from 0.25 2 years, 0.6 months. Their disease duration 4 13.75 6.5 years. significantly...

Elvan Caglar Citak MDa*, Aynur Oguz MDa, Ceyda Karadeniz Arzu Okur Leyla Memis MDb & Oznur Boyunaga MDca Gazi University Faculty of Medicine, Department Pediatric Oncology, Ankara, Turkeyb Pathology, Turkeyc Radiology, Turkey

Vincristine commonly induces peripheral neuropathy but rarely causes voiding dysfunction. In this report, we describe a case of neurogenic bladder and caused by the neurotoxic effect vincristine documented urodynamic testing electromyography. Neurologic evaluation aided in monitoring understanding problem.

We report the case of a 7-month-old breast fed infant who presented with nose bleed and bruises. Investigation showed severe nutritional B12 deficiency anemia pancytopenia. It is important to take history both mother for early prevention treatment.

The present study was carried out to clarify the role of matrix metalloproteinase-2 and -9 (MMP-2 MMP-9), tissue inhibitor metalloproteinase-1 (TIMP-1), vascular endothelial growth factor (VEGF), microvessel density (MVD) in clinicopathologic behavior childhood B-cell non-Hodgkin lymphoma (NHL). Paraffin-embedded biopsy specimens from 25 children with NHL were studied by immunohistochemically correlate expression these markers characteristics. Positive MMP-9 staining associated an increased...

Journal Article Adrenomedullin worsens skin necrosis in rats subjected to vincristine‐induced extravasation Get access V. Kesik, Kesik Departments of Pediatric Oncology Dr Vural Department Oncology, Gulhane Military Medical Academy, School Medicine, Etlik, Ankara 06018, Turkey E‐mail: vural73@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar B. Kurt, Kurt Pathology T. Tunc, Tunc Pediatrics, Faculty, Ankara, Y. Karslioglu, Karslioglu E. C. Citak, Citak Kismet,...

ORI GI