A5038172580- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Congenital Diaphragmatic Hernia Studies
- Ovarian cancer diagnosis and treatment
- Teratomas and Epidermoid Cysts
- Chromatin Remodeling and Cancer
- Hematopoietic Stem Cell Transplantation
- Vascular Malformations and Hemangiomas
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
Hacettepe University
2014-2024
Hacettepe University Hospital
2018-2023
Pediatric Oncology Group
2017-2023
Istanbul University
2021
Ministry of Health
2013-2017
Karadeniz Technical University
2017
Memorial Ankara Hospital
2014-2015
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2013
<h3>Importance</h3> Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations. The genetic susceptibility to osteosarcoma outside familial remains unclear. <h3>Objective</h3> To investigate architecture 1244 patients with osteosarcoma. <h3>Design, Setting, Participants</h3> Whole-exome sequencing (n = 1104) or targeted 140) DNA from 10 participating...
Abstract Background Aneurysmal bone cyst (ABC) is a benign tumor. Curettage and grafting the common treatment. Here, we retrospectively evaluate nine patients treated with denosumab. Procedure Nine ABC, mostly pelvic vertebral, denosumab were analyzed retrospectively. A 70 mg/m 2 dose was used weekly in first month, then monthly. Clinical radiological responses to treatment evaluated. Results In all patients, clinical symptoms including pain limping regressed completely within 3 months....
Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization, signs compression adjacent organs may be seen.A total 12 children with pathologically proven lipoblastoma from 2000 to 2014 were reviewed retrospectively for their clinical features, treatment follow up.There seven boys five girls between 7.5 months years age. The most common symptom was painless rapid-growing mass. tumors located in the neck, abdomen, groin, pelvis,...
Objective: We evaluated the myocardial damage in rats treated with doxorubicin (DOX) alone and combination nitric oxide synthase (nOS) inhibitors.Materials Methods: Twenty-four male Sprague Dawley (12 weeks old, weighing 262±18 g) were randomly assigned into 4 groups (n=6).Group I was control group.In Group II, intraperitoneal (ip) injections of 3 mg/kg DOX once a week for 5 weeks.In III, received weekly ip 30 L-nAME (nonspecific nOS inhibitor) min before IV, L-nIL (inducible weeks.Rats...
The national protocol aimed to improve the outcome of high risk neuroblastoma patients by high-dose chemotherapy and stem cell rescue with intensive multimodal therapy.After 6 induction cycles, without disease progression were nonrandomly (by physicians' and/or parent's choices) allocated into two treatment arms, which designed continue conventional (CCT), or myeloablative therapy autologous (ASCR).Fifty-six percent (272 patients) was evaluated as risk. Response rate 71%. Overall event-free...
We evaluated the myocardial damage in rats treated with doxorubicin (DOX) alone and combination nitric oxide synthase (NOS) inhibitors.Twenty-four male Sprague Dawley (12 weeks old, weighing 262±18 g) were randomly assigned into 4 groups (n=6). Group I was control group. In II, intraperitoneal (ip) injections of 3 mg/kg DOX once a week for 5 weeks. III, received weekly ip 30 L-NAME (nonspecific NOS inhibitor) min before IV, L-NIL (inducible Rats weighed 2 times week. At end 6 weeks, hearts...
Chylothorax refers to the presence of chyle in pleural space. There are multiple etiologies chylothorax. Our aim this study was evaluate clinical manifestations, causes, and treatment chylothorax childhood also show differences between 2 age groups admitted a tertiary care children's hospital. The second radiologic features patients diagnosed as having Gorham-Stout disease via chylothorax.The archives were reviewed for documented last 31 years. Twenty-two (11 girls 11 boys) included....
Pulmonary Langerhans cell histiocytosis (pLCH) is a rare disease, mostly component of multisystemic LCH. We aimed to investigate the clinical features and treatment results in children with pLCH.
Background. Children with cancer have a higher morbidity and mortality due to COVID-19. Vaccination of children is important. In this study, we aimed investigate the effectiveness side effects COVID-19 vaccines in adolescents cancer. Methods. Fifty-eight patients from four centers were included study. Antibodies SARS-CoV-2 spike protein levels measured. Vaccine-related complaints recorded. Results. There 33 male 25 female patients. The mean age was 16.9±2.3 years. 58.6% cases, diagnosis...
Through its receptor (VDR), vitamin D
Intracranial germ cell tumors (ICGCTs) comprise approximately 0.4%-3% of all brain tumors. In this study, we aim to evaluate clinical characteristics, treatment and outcomes patients with ICGCT.All ICGCT diagnosed in Hacettepe University's Pediatric Oncology Department between January 1980 2016 were evaluated, retrospectively.We identified 52 (male/female: 2.46) ICGT. Median age was 140 months. The median duration symptoms 3 Patients endocrine later than others (P = 0.028). primary site...
Primary paraspinal/spinal epidural lymphoma (PPSEL) is rare in childhood. Here, we retrospectively evaluated patients with PPSEL treated our department. We also reviewed the cases reported literature. Fifteen of 1354 non-Hodgkin diagnosed over a 38-year period were PPSEPL. There 11 male individuals and 4 female median age 13 years. Most common symptoms pain limb weakness. Physical examination revealed spinal cord compression 80% patients. The most tumor location was lumbar region....
Primary breast lymphoma is extremely rare and constitutes approximately 1% of all non-Hodgkin's lymphomas (NHL). Only 1-5% them are Burkitt type. We present a case childhood primary (BL). A 16-year-old female patient was referred to our hospital for bilateral swelling respiratory distress. She had lactic acidosis. Despite aggressive dialysis support, acid levels started decrease only after the combination chemotherapy treatment returned normal. Histopathological examination biopsy consistent...
Osteosarcoma is the most common primary malignant tumor of bone. The sites osteosarcoma in children are metaphysis long bones, especially distal femur, proximal tibia, and humerus. It occurs very rarely flat bones. Here we report a 14-year-old adolescent boy with fifth rib review literature.