A5043498418- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Congenital Diaphragmatic Hernia Studies
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Medical Imaging and Pathology Studies
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Neuroendocrine Tumor Research Advances
- Neonatal Respiratory Health Research
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Adrenal and Paraganglionic Tumors
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Cytomegalovirus and herpesvirus research
- Chronic Kidney Disease and Diabetes
- Tumors and Oncological Cases
- Urological Disorders and Treatments
- Soft tissue tumor case studies
- Lymphoma Diagnosis and Treatment
Hacettepe University
2016-2025
Ankara University
1995-2025
Hacettepe University Hospital
2006-2023
University of Toronto
2022
Advanced Neural Dynamics (United States)
2022
Research Institute Hospital 12 de Octubre
2019
Hospital Universitario Fundación Jiménez Díaz
2018
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2018
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2017
Ankara Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Ve Araştırma Hastanesi
2017
Abstract Background The VALidation of IGA (VALIGA) study investigated the utility Oxford Classification immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed central review Oxford. We had two distinct objectives: to assess how closely pathology findings associated with decision give corticosteroid/immunosuppressive (CS/IS) treatments, and determine impact differences MEST-C scoring between on clinical...
To elucidate the incidence of inducible nitric oxide synthase (iNOS) expression in benign prostatic hyperplasia (BPH), low- and high-grade intraepithelial neoplasia (PIN) carcinoma lesions, to explore role iNOS prostate tumorigenesis.Immunoreactivity for was examined 20 samples each BPH, PIN, low-grade PIN carcinoma.Positive immunostaining detected all from patients; both basal epithelial cells secretory glandular epithelium. High-grade had more intense than BPH samples. In samples, smooth...
Langerhans cell histiocytosis (LCH) is a disorder with unclear etiology and pathogenesis, which characterized by abnormal clonal proliferation accumulation of langerhans cells at various tissue organs. A total 217 patients LCH were evaluated retrospectively for clinicopathological features, laboratory findings, treatment modalities, long-term outcome, factors affecting the outcome. Median age time diagnosis was 3.5 years male/female ratio 1.8. The most common complaint presentation bone...
Aminoacyl-tRNA synthetases (ARSs) catalyze the first step of protein biosynthesis (canonical function) and have additional (non-canonical) functions outside translation. Bi-allelic pathogenic variants in genes encoding ARSs are associated with various recessive mitochondrial multisystem disorders. We describe here a clinical phenotype based on bi-allelic mutations two (FARSA, FARSB) distinct subunits for tetrameric cytosolic phenylalanyl-tRNA synthetase (FARS1). Interstitial lung disease...
We assessed the influence of clinical and pathological factors on multifocality renal cell carcinoma.Between June 1995 September 1999 radical nephrectomy was performed in 71 men 32 women with a mean age 56.5 years. The 103 removed kidneys carcinoma were sectioned at 3 mm. intervals inspected microscopically for satellite carcinomas. evaluated stage, grade, type, histological pattern, vascular involvement, tumor size incidence multifocality. To determine type we used several classification...
The aim of this study was to compare the fecal calprotectin concentration in children with newly diagnosed celiac disease, disease strictly adhering a gluten-free diet and healthy controls. We also tried correlate clinical presentation, degree neutrophilic infiltration severity histopathological injury (Marsh grade) small bowel mucosa.The included three groups: untreated treated Moreover, we obtained second sample from nine when their endomysial antibody became negative after diet.Fecal...
Lipoblastoma is a rare benign mesenchymal tumor of infancy and early childhood. Symptoms vary depending on localization, signs compression adjacent organs may be seen.A total 12 children with pathologically proven lipoblastoma from 2000 to 2014 were reviewed retrospectively for their clinical features, treatment follow up.There seven boys five girls between 7.5 months years age. The most common symptom was painless rapid-growing mass. tumors located in the neck, abdomen, groin, pelvis,...
Interstitial lung disease, nephrotic syndrome and junctional epidermolysis bullosa is an autosomal recessive multiorgan disorder caused by mutations in the gene for integrin α3 subunit (ITGA3). The full spectrum of manifestations genotype–phenotype correlations still poorly characterized. Here, we uncovered disease-causing role molecular mechanisms underlying a homozygous ITGA3 mutation leading to single amino acid substitution, p.R463W. patient suffered from respiratory distress episodes...
Childhood-onset systemic lupus erythematosus (SLE) is more severe than adult-onset disease, including frequent kidney involvement. This study aimed to investigate baseline clinical features, treatment modalities and short- long-term renal outcomes of paediatric patients with nephritis (LN).This enrolled 53 LN out 102 childhood-onset SLE followed at Hacettepe University between 2000 2020. The demographic data were reviewed retrospectively from the medical charts electronic records. All...
Aim A retrospective study was performed to evaluate the clinical features, diagnostic methods, and treatment alternatives of childhood inflammatory myofibroblastic tumors (IMTs). Patients Methods who underwent surgical for IMT between 2000 2015 were evaluated age, sex, presenting symptoms, physical examination findings, modalities, histopathologic results during long-term follow-up. Results Eleven patients included in study. Male:female ratio 7:4 mean age 6.09 years (1-10 years). Presenting...