A5009440395- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Inflammatory Myopathies and Dermatomyositis
- Chromatin Remodeling and Cancer
- Caveolin-1 and cellular processes
- Immune Cell Function and Interaction
- Tumors and Oncological Cases
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Hereditary Neurological Disorders
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Metabolism and Genetic Disorders
- Dermatological and Skeletal Disorders
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
İzmir Demokrasi Üniversitesi
2019-2025
Izmir University
2014-2025
İzmir University of Economics
2020-2024
Ordu University
2023
Breast Cancer Care
2022
Sağlık Bilimleri Üniversitesi
2018-2021
Creative Commons
2020
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2014-2019
Muğla University
2019
Türkisch-Deutsche Universität
2019
Background . We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods IL-10, IL-17, TGF- β , IFN- γ IL-35 serum levels allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by skin prick test. Patients only with olive tree sensitivity evaluated seasonal AR (SAR). mite included perennial (PAR). clinic severity nasal symptom scores (NSS). Results...
<h3>Background</h3> Triple A syndrome (MIM #231550) is associated with mutations in the <i>AAAS</i> gene. However, about 30% of patients triple symptoms but an unresolved diagnosis do not harbour <i>AAAS</i>. <h3>Objective</h3> Search for novel genetic defects families a A-like phenotype whom are detected. <h3>Methods</h3> Genome-wide linkage analysis, whole-exome sequencing and functional analyses were used to discover verify defect two achalasia, alacrima, myopathy further symptoms. Effect...
Limb-girdle muscular dystrophy (LGMD) is the fourth most common dystrophy, with progressive proximal muscle weakness. However, a large number of neuromuscular conditions are similarly presented. Because this, use high-throughput methods such as next-generation sequencing (NGS) important in evaluation LGMD.In this report, we applied custom target capture-based NGS panel covering 31 LGMD-associated genes (MYOT, LMNA, CAV3, DES, DNAJB6, FLNC, CAPN3, DYSF, SGCG, SGCA, SGCB, SGCD, TCAP, TRIM32,...
O câncer de colo do útero é uma das principais causas mortalidade entre mulheres no Brasil e mundo, sendo prevenível por meio rastreamento regular. No entanto, diversos fatores dificultam a adesão ao exame Papanicolau comprometem efetividade dos programas rastreamento. Esta revisão integrativa teve como objetivo identificar analisar as barreiras estratégias para ampliação Brasil. Foram revisados estudos publicados 2000 2023, extraídos bases científicas PubMed, SciELO LILACS. Os resultados...
Stroke is one of the leading causes death and disability in Brazil worldwide. Medical intervention early hours after event essential to reduce sequelae mortality. This study aimed review main types stroke hemorrhagic ischemic context medical emergencies describe updated clinical approaches.
Background: The survival rate among stomach adenocarcinoma patients is exceedingly low. NGAL (neutrophil gelatinase-associated lipocalin) has pivotal roles in cell proliferation, immunity, and tumorigenesis. KIM-1 (Kidney Injury Molecule-1), also referred to as TIM-1 HAVcr-1, a transmembrane glycoprotein located healthy immune cells epithelial cells, its upregulated form generally found several human cancers. Aim: aim of this study was investigate the prognostic significance expression...
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein involved in chromatin remodeling, transcription, DNA replication, and repair. The purpose of this study was to assess the relationship between tissue expression HMGB1, clinical outcomes, histopathological characteristics patients with breast cancer. included 282 An vitro diagnostic HMGB1 antibody applied slides tumor specimens. Overexpression found cells 123 (43.6%) patients. only expressed nucleus most tumors...
Melanotic Schwannoma (MS) is rarely seen and potentially malignant neoplasm that categorized as a variant of Schwannoma. MS most frequently involves intracranial structures followed by posterior nerve roots in the spinal canal. Approximately 50% cases with have psammomatous calcifications this type related to Carney complex autosomal dominant inheritance. Most are benign, though 10% them metastatic potential. mimics melanoma differential diagnosis should be made excluding other melanin...
Background: Although the importance of microsatellite instability (MSI) and mismatch repair genes (MMR) is strongly established in colorectal cancer seen Lynch syndrome, its significance has not been fully Wilms tumor (WT). The aim this study was to determine prognostic value MSI MMR proteins WT. Methods: This included 45 pediatric cases with nephroblastoma. Protein expression analyzed by immunohistochemistry archival tissue sections. Real-time PCR melting analysis fluorescence capillary...
Dihydropyridine receptor congenital myopathy is a recently described caused by dominant or recessive mutations in the CACNA1S gene. To date, only 11 cases from 7 families were single report. Here, we describe consanguineous family with three affected children, presenting hypotonia, contractures, ophthalmoplegia and respiratory insufficiency, novel homozygous mutation They also showed cognitive delay, pes equinovarus deformity neurogenic changes that have not been associated this previous...
Pathogenic variants in SURF1, a nuclear-encoded gene encoding mitochondrial chaperone involved COX assembly, are one of the most common causes Leigh syndrome (LS). Sixteen patients diagnosed to have SURF1-related LS between 2012 and 2020 were included study. Their clinical, biochemical molecular findings recorded. 10/16 using whole-exome sequencing (WES), 4/16 by Sanger 1/16 via targeted exome patient with whole-genome (WGS). The pathogenicity SURF1 was evaluated phylogenetic studies...
Telomerase activity provides telomere maintenance in chromosomes. It prevents cells from entering senescence. is one of the crucial steps various cancers. Wilms tumor (nephroblastoma) most common solid tumors childhood. Hitherto, telomerase reverse transcriptase (TERT) catalytic subunit expression has not been investigated widely. The aim this study was to explore level human TERT and correlate with some clinical prognosis factors such as weight, stage, histology, Ki67 expression. This...
Objective: The studies considering the clinical and histopathological features of childhood muscle disease are scarce in number worldwide. This study aims to examine profile children’s biopsies evaluated at Behcet Uz Children’s Hospital (BUCH) determine their correlation with diagnosis. Methods: We retrospectively reviewed 323 children who underwent biopsy examination between 2004 2011 pathology laboratory Izmir BUCH. All patients were clinically diagnosed as neuromuscular disorders...
Previous studies have demonstrated that Caveolin-1 (Cav-1) can ambiguously behave as tumor suppressor or promoter in different neoplasms, depending on cancer type. Some findings also revealed cell proliferation, migration and invasion were attenuated by the knockdown of expressions. However, functional prognostic significance most tumors remains to be fully elucidated.The aim study was investigate a possible association between tissue expression clinicopathologic features ovarian serous...
Apoptosis-related genes and proteins proliferation activity their relationship with Epstein-Barr virus (EBV) is a contemporary issue. In this study, prognostic or pathogenetic roles of EBV latent infection, proliferating activity, apoptosis-regulating in pediatric Hodgkin lymphomas were explored. EBV-EBER, lmp-1, ki-67, bcl-2, survivin, Bax, fas, c-myc, p53, apoptotic index analyzed 63 lymphoma cases. The results evaluated by chi-square, Mann Whitney U test, Pearson correlation analysis,...
Introduction:: Idiopathic Pulmonary Hemosiderosis (IPH) is a rare cause of alveolar hemorrhage, which seen primarily in childhood. Celiac disease defined as chronic, immune-mediated enteropathy the small intestine, caused by exposure to dietary gluten genetically pre-disposed individuals. Association IPH and celiac known Lane Hamilton syndrome. There are limited number case reports this syndrome literature. Case Presentation:: Although there were no growth developmental delay...
Abstract Objectives Diagnostic process of mitochondrial disorders (MD) is challenging because the clinical variability and genetic heterogeneity these conditions. Next-Generation Sequencing (NGS) technology offers a high-throughput platform for nuclear MD. Methods We included 59 72 patients that undergone WES targeted exome sequencing panel suspected to have potential PMDs. Patients who were in analysis considering possible PMD reviewed retrospectively scored according Mitochondrial Disease...
Lupus vulgaris is the most common form of cutaneous tuberculosis which usually occurs in patients previously sensitized to Mycobacterium tuberculosis. We present a case 10-year-old boy who was diagnosed as lupus clinically and histopathologically. He had well demarcated, irregularly bordered, pink, infiltrated plaques on his left cheek showing apple-jelly appearance diascopy. The histopathological examination showed tuberculoid granulomas with Langhans type giant cells. Mantoux reactivity...