A5083981582- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- IL-33, ST2, and ILC Pathways
- Vasculitis and related conditions
- interferon and immune responses
- Renal Diseases and Glomerulopathies
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Heterotopic Ossification and Related Conditions
- Osteomyelitis and Bone Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peptidase Inhibition and Analysis
- Child and Adolescent Health
- Orthopedic Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Issues in Pregnancy
- Liver Diseases and Immunity
- Coronary Artery Anomalies
Istanbul University
2020-2025
Center for Rheumatology
2023
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi
2017-2022
Sağlık Bilimleri Üniversitesi
2019-2022
Erzurum Regional Training and Research Hospital
2021-2022
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2021
University of Health Science
2019-2021
İstanbul Eğitim ve Araştırma Hastanesi
2021
Kocaeli Üniversitesi
2021
Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic
2021
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease manifesting phenotypic heterogeneity. It a clinically diagnosed supported by MEditerranean FeVer (MEFV) gene mutation analysis. However, phenotype-genotype correlation not yet established clearly. We aimed to determine clinical findings, correlation, and treatment outcomes within large pediatric FMF cohort. The medical charts of children with who were followed up at eight rheumatology units reviewed...
Abstract The diagnosis and treatment of rare diseases present significant global challenges. This study aimed to identify the difficulties faced by specialists in management diseases, as well gather their recommendations for potential solutions. An expert committee specializing inborn metabolic disease genetics developed a comprehensive survey, which was then distributed online professionals working with diseases. A total 21 actively engaged participated survey. All participants acknowledged...
Henoch-Schönlein Purpura (HSP) is the most common self-limiting vasculitis of childhood. Both serious gastrointestinal and renal complications may be observed during disease course. The aim this study was to evaluate role hematological markers in predicting likely disease.The demographic findings, clinical features, organ involvements laboratory findings including white blood cell count (WBC), neutrophil, lymphocyte platelet counts, C-reactive protein (CRP), erythrocyte sedimentation rate...
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic in children. It a group heterogeneous disorders that have as feature. has worldwide distribution and many studies shown subtype frequencies JIA seem to be showing geographical distribution. The aim this study was define frequencies, demographic features, rates macrophage activation syndrome, uveitis remission Turkish patients. files all patients (378 cases) were being followed Pediatric Rheumatology Clinic our...
The aim of this observational study was to evaluate whether there any correlation between the acute phase reactants in children with familial Mediterranean fever (FMF) during attack and attack-free periods.The conducted June 2016 January 2018. Clinical features laboratory parameters FMF periods were recorded longitudinally.The cohort consisted 168 (84 boys, 84 girls). Median values attacks 433.5 mg/L (34.0-1780.0 mg/L) for serum amyloid A (SAA), 56.7 (7.6-379.0 C-reactive protein (CRP), 37.5...
Objectives: The aim of this study was to demonstrate the frequency macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) cases, compare laboratory tests at time diagnosis sJIA and MAS see whether cases complicated with follow a more severe disease course long-term follow-up. Methods: Files children that were followed between May 2010 September 2017 reviewed. Results: cohort consisted 53 cases. Mean duration follow-up 39.0 ± 24.1 months. 33.9%. Initial compared...
To define the demographic, clinical and genetic features of familial Mediterranean fever (FMF) patients with early disease onset to compare them late-onset FMF patients. Patients were divided into two groups according age onset: group 1 includes who had their first attack ≤3 years age; 2 consisted >3 age. Furthermore, we compared proportion fulfilling three diagnostic criteria among groups. Of 1687 patients, 761 at while 926 presented manifestation years. Delay in diagnosis, peritonitis...
Abstract Introduction Transition is a planned process of pediatric patients from child‐centered to adult‐oriented treatment. Transitional care for with chronic diseases essential. The present study aimed evaluate the readiness rheumatic and their parents transition process. Method This cross‐sectional, single‐center study. All were questioned about awareness willingness undergo transitional care. Readiness Assessment Questionnaire (TRAQ) was applied all participants. TRAQ tool measuring in...
Introduction: Systemic lupus erythematosus (SLE) may present with features of several systems, including hematological manifestations. In this study, we aimed to evaluate the characteristics involvement and assess possible associations correlations in pediatric SLE patients. Method: This is a retrospective multi-center study. The medical records patients followed between January 2000 June 2020 were analyzed. All children fulfilled criteria Lupus International Collaborating Clinics. Results:...
To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.A total 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers Turkey were enrolled study. LLDAS-50 was defined as encountering LLDAS at least 50% observation time. According to achievement LLDAS-50, clinical features, immunological profiles, and treatments jSLE have been revealed.LLDAS any...
Abstract Objectives The aim of this study is to investigate the effect anti-interleukin (IL)-1/-6 biologics on systemic juvenile idiopathic arthritis (sJIA)-associated macrophage activation syndrome (MAS). Methods Demographic, clinical and laboratory data patients followed up with a diagnosis sJIA-associated MAS assessed from sixteen paediatric rheumatology centres across country. features developing while biological drugs were compared those without treatment. Results One hundred sixty-two...
Background and Objectives. The aim of this observational retrospective cohort study was to demonstrate indications response rates the patients with pediatric rheumatic diseases that used canakinumab. Method. files canakinumab between December 2012 July 2017 were reviewed. Canakinumab in 29 patients. Diagnosis were; colchicine resistant familial Mediterranean fever (crFMF) (19 cases), hyperimmunoglobulin D syndrome-mevalonate kinase deficiency (HIDS-MKD) (3 cryopyrin-associated periodic...
The aims of this study were to compare demographic data, clinical features, and severity scores familial Mediterranean fever patients carrying E148Q variant with the having homozygous pathogenic MEFV mutations evaluate both these groups for performance Tel-Hashomer, Livneh, pediatric diagnostic criteria.The data either heterozygous or (group 1) (M694V, M694I, M680I, V726A) 2) collected retrospectively. All evaluated 3 criteria.E148Q was present in 128 (22.9%), 112 whom had 16 mutation. Group...
The aim of this study was to evaluate the outcomes patients with multisystem inflammatory syndrome in children (MIS-C) according phenotypes disease and define prognostic factors for severe course. This cross-sectional included 293 MIS-C from seven pediatric rheumatology centers. A two-step cluster analysis performed spectrum their were compared between each group. Four subgroups identified as follows: I, predominantly Kawasaki-like features (n = 100); II, MAS-like 34); III, LV dysfunction...
Behçet's disease (BD) is a systemic vasculitis affecting many organ systems, with the involvement of all-sized arteries and veins. The study aims to determine main characteristics paediatric BD patients also analyse clustering phenotypes.Demographic data, clinical manifestations, laboratory features, treatment schedules, outcomes were achieved from patients' charts retrospectively. A cluster analysis was performed according phenotype.A total 225 (109 male/116 female) enrolled in study....