A5077037506- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Immunodeficiency and Autoimmune Disorders
- Mechanical Circulatory Support Devices
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Ocular Diseases and Behçet’s Syndrome
- IL-33, ST2, and ILC Pathways
- Musculoskeletal Disorders and Rehabilitation
- Systemic Sclerosis and Related Diseases
- IgG4-Related and Inflammatory Diseases
- Eating Disorders and Behaviors
- Dermatologic Treatments and Research
- Gout, Hyperuricemia, Uric Acid
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Galectins and Cancer Biology
- Cholesterol and Lipid Metabolism
- Osteomyelitis and Bone Disorders Research
- Vascular Anomalies and Treatments
- Inflammatory Bowel Disease
Hacettepe University
2019-2025
Center for Rheumatology
2022
We aimed to delineate the distinctive characteristics that aid in distinguishing between Kawasaki disease (KD) and multisystem inflammatory syndrome children (MIS-C) with KD-like manifestations during pandemic.
The impact of the COVID-19 pandemic, and implemented restrictions on frequency pediatric rheumatic diseases remain unknown, while they have probably prevented common infections in children. We present effects our rheumatology practice a main referral center. retrospectively reviewed medical records patients presenting to department 4 years before March 2020 compared it pandemic year (March 2020–March 2021). Since there was an overall decrease patient numbers, we calculated percentage...
Abstract Objectives Colchicine forms the mainstay of treatment in FMF. Approximately 5–10% FMF patients are colchicine resistant and require anti-IL-1 drugs. We aimed to compare characteristics colchicine-resistant colchicine-responsive develop a score for predicting resistance at time diagnosis. Methods (0–18 years) enrolled Turkish Paediatric Autoinflammatory Diseases (TURPAID) registry were included. The predictive was developed by using univariate/multivariate regression receiver...
Background Drug-induced lupus erythematosus (DILE) is the development of lupus-like syndrome following a drug exposure. DILE has been reported less frequently among children than adults. Methods In this study, we present four with and similar published cases through systematic literature review. Results We report (three girls one boy) who developed associated use topiramate, doxycycline, etanercept, ethosuximide. Three them were positive for anti-histone antibodies. all patients, was...
The lower extremity venous wall thickness (VWT) of Behçet's disease (BD) patients was reported to be significantly increased in adults, suggesting its use for the support BD diagnosis. This prospective study aimed investigate VWT childhood-onset definite and incomplete compare it healthy age-matched controls.Paediatric classified with according 2015 international paediatric criteria our centre were included study. Intima-media veins evaluate measured by ultrasonography, including common...
We aimed to identify and compare systemic juvenile idiopathic arthritis (sJIA) patients receiving treatment with either glucocorticoids and/or conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or biologic drugs. This was a retrospective cross-sectional study. sJIA (n=138) were categorized into two groups: Group A (n=51) consisted of individuals who received only csDMARDs, while B (n=87) included those at least one drug. exhibited higher prevalence macrophage activation...
Abstract Objectives There is no consensus on canakinumab treatment tapering and discontinuation strategies in colchicine-resistant FMF patients. In this study, we aimed to establish a management protocol paediatric patients treated with canakinumab. Methods Fifty-eight were included. Since 2020, have applied based our experience whereby administered monthly the first 6 months, followed by bimonthly for final period of every 3 months (for months). The divided into two groups: 2012–2019 (group...
Abstract Objectives FMF is characterized by febrile polyserositis attacks. Menstruation could be a trigger for We aimed to analyse the features of adolescent patients with menstruation-associated attacks and propose management algorithm. Methods All female who had menarche visited Pediatric Rheumatology Unit between January December 2022, were included into this study. Demographics, general characteristics menstrual cycle noted. Results A total 151 included. Thirty-five (23.2%) Fever...
Abstract Objectives The transition of adolescents and young adults (AYAs) from pediatric to adult-oriented healthcare may be affected by many factors, including the personal cultural settings. We aimed analyse readiness factors affecting success in rheumatology. Methods Patients older than 12 years were included this prospective study. All filled out Transition Readiness Assessment Questionnaire (TRAQ) 5.0. AYAs phone-interviewed after their transfer healthcare. Drug adherence was evaluated...
Background/aim: Video pediatric gait, arms, leg, and spine (v-pGALS) is a virtual application of (pGALS) examination performed by video. We aimed to verify the applicability, validity, accuracy Turkish translation v-pGALS in large patient cohort.Materials methods: Children aged 4-18 years were included between May June 2022. A hands-on physical performed. Demographics, active symptoms, findings, diagnosis, findings recorded. The acceptability parent/patient was measured using visual analog...
Multisystem inflammatory syndrome in children (MIS-C) is a serious condition characterized by excessive inflammation that can arise as complication of SARS-CoV-2 infection children. While our understanding COVID-19 and MIS-C has been advancing, there still uncertainty regarding the optimal treatment for MIS-C. In this study, we aimed to compare clinical laboratory outcomes patients treated with IVIG plus corticosteroids (CS) those CS an additional biologic drug. We used propensity score...
Biologics are new treatment alternatives in Takayasu arteritis (TA), although data childhood limited. The aim of this study was to share our experience seven childhood-onset TA patients who received a TNF-α inhibitor (adalimumab) or an IL-6 receptor (tocilizumab) and the effect switching therapy.We retrospectively evaluated medical records with TA, followed between August 2005 January 2021 at Pediatric Rheumatology Department Hacettepe University Faculty Medicine.The median age 14 (IQR 4)...
Abstract Objectives Takayasu arteritis (TAK) is a large-vessel vasculitis rarely reported in children and infants. Most articles on paediatric TAK have not focused We present the largest case series of infantile TAK, aiming to identify its demographic clinical characteristics compare them with existing data older children. Methods conducted an international multicentre retrospective cohort study. Epidemiological were collected from patients’ charts six rheumatology centres. All patients met...
ABSTRACT Objectives Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe condition associated with coronavirus disease 2019. Here we aimed to raise awareness for the symptoms of MIS-C patients rheumatic diseases, emphasizing challenges differential features. Methods We retrospectively evaluated demographic and clinical characteristics, laboratory imaging findings, treatments, outcomes six previous disease. Results Three had familial Mediterranean fever (FMF), one...
Background. In this study, we aimed to evaluate choices and changes of biologic drugs in juvenile idiopathic arthritis (JIA) patients according disease subtypes. Methods. We retrospectively analyzed JIA who received treatment between January 2004 July 2022. Results. Of 294 patients, 80 (27.2%) had systemic JIA, 68 (23.1%) oligoarticular 61 (20.7%) polyarticular 79 (26.9%) enthesitis-associated (ERA), six (2.1%) psoriatic (PsA). Anakinra (n=66, 82.5%) was the most commonly preferred first...