Gülçin Otar Yener
A5074826006- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Ocular Diseases and Behçet’s Syndrome
- IL-33, ST2, and ILC Pathways
- Vasculitis and related conditions
- Bacterial Infections and Vaccines
- Gout, Hyperuricemia, Uric Acid
- Retinal and Optic Conditions
- Coronary Artery Anomalies
- Family and Disability Support Research
- Mechanical Circulatory Support Devices
- Systemic Lupus Erythematosus Research
- Pneumonia and Respiratory Infections
- Renal Diseases and Glomerulopathies
- Cardiovascular Issues in Pregnancy
- Inflammatory Myopathies and Dermatomyositis
- Cerebral Venous Sinus Thrombosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hip disorders and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Spondyloarthritis Studies and Treatments
- Autoimmune Bullous Skin Diseases
- Childhood Cancer Survivors' Quality of Life
Eskişehir City Hospital
2024-2025
Medical Park Gaziantep Hospital
2022-2024
Pamukkale University
2017-2024
Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi
2021-2023
Center for Rheumatology
2023
Memorial Ankara Hospital
2021
Istanbul University
2019
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease manifesting phenotypic heterogeneity. It a clinically diagnosed supported by MEditerranean FeVer (MEFV) gene mutation analysis. However, phenotype-genotype correlation not yet established clearly. We aimed to determine clinical findings, correlation, and treatment outcomes within large pediatric FMF cohort. The medical charts of children with who were followed up at eight rheumatology units reviewed...
Aim Multisystem inflammatory syndrome in children (MIS‐C) may cause shock and even death children. The aim of this study is to describe the clinical features, laboratory characteristics outcome diagnosed with MIS‐C 25 different hospitals Turkey. Methods retrospective was conducted between 8 April 28 October 2020 from 17 cities. Data were collected patients' medical records using a standardised form. Clinical outcomes according age groups, gender body mass index percentiles compared...
Objective The study aimed to report the efficacy and safety of anakinra treatment in patients with refractory multisystemic inflammatory syndrome children (MIS-C). Methods This is a cross-sectional retrospective consisting pediatric diagnosed MIS-C who were treated anakinra. Results Among 378 MIS-C, 82 (21.6%) included study. median age was 115 (6-214) months. duration hospitalization 15 (6-42) days. Sixty (73.1%) admitted intensive care unit. Patients dose 2.7 mg/kg/day concomitant IVIG...
Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and used in combination with systemic corticosteroids treatment of many childhood rheumatic diseases, such as lupus erythematosus (SLE), ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged new alternative modality over CYC for induction therapy childhood-onset diseases. Clinicians adopt different practices...
This study aimed to evaluate the predictability of homozygous M694V genotype in pediatric familial Mediterranean fever (FMF) patients and develop a clinical scoring system enhance disease management strategies. nationwide, multicentre, cross-sectional included 3,981 FMF with biallelic pathogenic variants exon 10 Fever gene. Patients were divided into two groups: group 1 (homozygous M694V) 2 (other variants). Data collected from 37 rheumatology and/or nephrology clinics across Türkiye,...
The effects of biological disease-modifying antirheumatic drugs (bDMARDs) in the clinical course COVID-19 on children with underlying rheumatologic diseases have not been fully demonstrated. To evaluate infection patients rheumatic disease receiving bDMARD treatment. This was a retrospective, multicenter study conducted pediatric infected by SARS-CoV-2 and under bDMARDs therapy. population consisted 113 (72 female/41 male). mean age 12.87 ± 4.69 years. primary diagnosis cohort as follows: 63...
To determine the rate of achieving The Lupus Low Disease Activity State (LLDAS) in children with systemic lupus erythematosus (SLE) for tracing pertinent treatment modalities.A total 122 juvenile-onset SLE (jSLE) patients from six pediatric rheumatology centers Turkey were enrolled study. LLDAS-50 was defined as encountering LLDAS at least 50% observation time. According to achievement LLDAS-50, clinical features, immunological profiles, and treatments jSLE have been revealed.LLDAS any...
Abstract Objectives The aim of this study is to investigate the effect anti-interleukin (IL)-1/-6 biologics on systemic juvenile idiopathic arthritis (sJIA)-associated macrophage activation syndrome (MAS). Methods Demographic, clinical and laboratory data patients followed up with a diagnosis sJIA-associated MAS assessed from sixteen paediatric rheumatology centres across country. features developing while biological drugs were compared those without treatment. Results One hundred sixty-two...
We report the case of a 2.5 month-old infant with cyanotic breath-holding spells, loss consciousness and seizures. Prolonged asystole up to 70 s despite cardiopulmonary resuscitation was documented by 24 hour Holter monitoring. An epicardial pacemaker implanted followed no further seizures during spells in six month follow-up period.
The aim of this study was to evaluate the outcomes patients with multisystem inflammatory syndrome in children (MIS-C) according phenotypes disease and define prognostic factors for severe course. This cross-sectional included 293 MIS-C from seven pediatric rheumatology centers. A two-step cluster analysis performed spectrum their were compared between each group. Four subgroups identified as follows: I, predominantly Kawasaki-like features (n = 100); II, MAS-like 34); III, LV dysfunction...
Behçet's disease (BD) is a systemic vasculitis affecting many organ systems, with the involvement of all-sized arteries and veins. The study aims to determine main characteristics paediatric BD patients also analyse clustering phenotypes.Demographic data, clinical manifestations, laboratory features, treatment schedules, outcomes were achieved from patients' charts retrospectively. A cluster analysis was performed according phenotype.A total 225 (109 male/116 female) enrolled in study....
To develop a novel scoring system to predict colchicine resistance in Familial Mediterranean fever (FMF) based on the initial features of patients.The medical records patients were analyzed prior initiation colchicine. After generating predictive score cohort, it was applied an independent cohort for external validation effectiveness and reliability.Among 1418 with FMF, 56 (3.9%) resistant (cr) 1312 (96.1%) responsive. Recurrent arthritis (4 points), protracted febrile myalgia (8...
Background. The aim of the study was to evaluate approaches pediatric rheumatologists and hematologists patients with similar musculoskeletal (MSK) complaints highlight differences that general pediatricians should consider when referring these specialties. Methods. This is a cross-sectional involving who applied rheumatology centers MSK were diagnosed malignancy, as well followed up in hematology malignancy diagnosis, had at time admission. Results. A total 142 enrolled study. Of patients,...
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) are the most common autoinflammatory syndromes in children. This study aimed to evaluate clinical laboratory parameters that may predict colchicine responsiveness.This retrospective, multicenter, cross-sectional involved nine pediatric rheumatology centers from our country., The patients diagnosed with PFAPA were compared on basis of their responses colchicine. In 806 (42.3% female 57.7% male) patients,...
In this study, we aimed to describe the demographic and clinical findings of children with uveitis at a tertiary pediatric rheumatology ophthalmology center.A retrospective cross-sectional study was conducted 46 patients who were diagnosed before age 16 years followed regularly for least 6 months between January 2013 June 2019. Demographic data, characteristics, underlying diseases, systemic treatment modalities, drug side effects, complications, surgical intervention evaluated.Eighty-three...
To evaluate the safety of canakinumab using real-world data in patients with systemic juvenile idiopathic arthritis (sJIA) and autoinflammatory diseases (AID).