A5048270632- Parvovirus B19 Infection Studies
- Tracheal and airway disorders
- Bacterial Infections and Vaccines
- Autoimmune and Inflammatory Disorders Research
- Pneumonia and Respiratory Infections
- Dermatological and COVID-19 studies
- Respiratory viral infections research
- Celiac Disease Research and Management
- Congenital Diaphragmatic Hernia Studies
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Appendicitis Diagnosis and Management
- Virology and Viral Diseases
- Kawasaki Disease and Coronary Complications
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Viral-associated cancers and disorders
- Brucella: diagnosis, epidemiology, treatment
- Neurosurgical Procedures and Complications
- Nosocomial Infections in ICU
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Amoebic Infections and Treatments
Istanbul Medipol University
2020-2025
Intensive Care Society
2021
Şişli Etfal Eğitim ve Araştırma Hastanesi
2002-2015
Pediatrics and Genetics
2015
Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basin, despite high prevalence of human herpesvirus-8 (HHV-8) infection this region. We hypothesized that single-gene inborn errors immunity to HHV-8 may underlie classic KS childhood. investigated a child with no other unusually severe infectious or tumoral phenotype who died disseminated at two years age. Whole-exome sequencing patient revealed homozygous splice-site mutation STIM1, gene encoding stromal...
Influenza is a common cause of hospital admissions worldwide, and an increase in influenza cases has been observed following the COVID-19 pandemic. Our study investigated epidemiological clinical characteristics pediatric patients with infection admitted to intensive care units (PICUs) Istanbul, Turkey, We conducted retrospective confirmed who were 1 11 PICUs between July 1, 2022, June 30, 2024. Data on demographic characteristics, risk factors, presentations, microbiological findings,...
Infection by human herpesvirus 8 (HHV-8) in childhood is common the Mediterranean basin; however, classic Kaposi sarcoma (KS) exceedingly rare children not infected with HIV and receiving immunosuppression, only 30 cases having been reported since 1960. We recently 2 autosomal X-linked recessive primary immunodeficiencies underlying KS a context of multiple clinical manifestations. These reports suggested that otherwise healthy might also result from inborn errors immunity more specific to...
Management of multidrug-resistant Acinetobacter baumannii (MDRAB) meningitis/ventriculitis is a difficult therapeutic problem owing to the limited penetration antibiotics into cerebrospinal fluid (CSF). A 2-month-old girl with ventriculitis caused by MDRAB reported. Despite therapy intravenous (IV) colistin ventricular fluid, cultures remained positive for MDRAB. Institution combination IV and intraventricular resulted in successful clinical microbiological outcome....
Pancytopenia, although mainly reported in adults, has also been described children with brucellosis. However, bone marrow hypoplasia is a rare feature of the infection. An 11-year-old boy was admitted fever, vomiting, and abdominal pain 10 days' duration. On physical examination, pallor high fever were detected absence lymphadenopathy hepatosplenomegaly. His hemoglobin 8.6 g/dL, white blood cell count 1,100/mm3, neutrophil 500/mm3, platelets 56,000/mm3, reticulocytes 0.1%. Hypocellular found...
Diagnosis of tuberculosis (TB) in children is more challenging than adults. This study aimed to describe demographical, clinical and laboratory findings diagnosed with Turkey, including the issues contact tracing, culture positivity forms disease.Clinical data 51 a mean age 8.0±4.6 years who were TB retrospectively reviewed. Main diagnostic tools included tuberculin skin test, chest X-ray, sputum/gastric aspirate sensitivity testing, direct microscopy for acid-fast bacilli on available...
Flexible bronchoscopy (FB) is frequently used for assessment and treatment of patients with respiratory diseases. Our aim was to investigate the contribution FB diagnosis therapy in children admitted intensive care units (ICU) evaluate safety this vulnerable population.Children less than 18 years age who underwent five neonatal pediatric ICUs Istanbul between July 1st, 2015 2020 were included study. Demographic clinical data including indications, findings, complications, management...
This study aims to evaluate the clinical course of human rhinovirus/enterovirus (HRV/EV) infections in pediatric intensive care unit.The was conducted as a multicenter, prospective observational from September 2022 December 2022. Cases with positive polymerase chain reaction testing for HRV/EV nasopharyngeal swab samples within first 24 hours unit admission were recorded. There 2 groups: 1-24 months and >24 months.A total 75 cases (39 male) included study. The median age all 21 months....
(Ph-like) ALL is a subset of leukemia which has gene expression profile similar to Ph+disease, but without the presence BCR-ABL1 translocation.We reported an exceptional case child with relapsed Ph-like IKZF1 deletion treated high-dose ruxolitinib as monotherapy, after multi-agent chemotherapy. He remains in continued MRD-negative remission full donor chimerism at 12 months post-HSCT.The circumstance that makes our featured usage monotherapy. This report, we believe, pioneering report for...
Abstract: A 15‐month‐old boy was admitted with fever and a swollen knee. His mother had been treated for brucellosis 11 months ago. At that time he asymptomatic both negative blood culture serum agglutination tests breastfeeding stopped. The infant healthy since then. On admission, joint fluid were obtained commenced on cefuroxim. Gram‐negative coccobacillary organisms seen in the fluid. Both cultures remained sterile. He positive test titer of 1/640. Cefuroxim then stopped child specific...
The aim of the study was to evaluate respiratory syncytial virus (RSV) infections in cases followed pediatric intensive care unit (PICU). designed as a prospective cohort 6 PICUs. There were 3 groups: only RSV (+), (v+) who positive for another viral agent(s) addition RSV, and (b+) bacterial RSV. A total 119 included study, 67 (56.3%) whom male. (+) group had lower pH compared other groups higher rate acute bronc hiolitis/bronchitis diagnoses group. bicarbonate levels, creatinine longer...
In this study, we sought to describe the clinical, laboratory, and genetic character- istics of patients diagnosed with primary hemophagocytic lymphohistiocytosis. Thus, aimed evaluate early diagnosis appropriate treatment options for pediatric hemophago- cytic lymphohistiocytosis patients.Medical records 9 between November 2013 December 2019 were analyzed retro- spectively. Clinical, genetic, laboratory characteristics, family histories, initial complaints, physical examination findings,...
Hodgkin lymphoma (HL) is predominantly a nodal disease with extranodal presentation being uncommon. Presentation neurological symptoms not uncommon in adult patients HL. Subdiaphragmatic involvements are less common especially childhood. In the literature, there has been no case which presented both spinal cord compression and bilateral hydronephrosis pediatric HL.We report 9-year-old boy diagnosed HL who epidural involvement.Differential diagnosis of abdominal mass presenting and/or should...
Amaç: Çalışmamızda son bir yılda akut karın ağrısı nedeniyle acil gözlemde izlenen hastaların, klinik spektrumu, fizik bakı, laboratuvar ve görüntüleme bulgularının seyirlerinin irdelenmesini amaçladık
Background and aims: Congenital diaphragmatic hernia occurs as a result of defect in the closure pleuroperitoneal pleat. It is usually presented with respiratory distress after birth rarely presentation delayed. Mild or severe symptoms, such obstruction gastrointestinal tract may be observed. Aims: We report case late presenting congenital hernia. Methods: A 10 month-old male infant admitted to our hospital distress. He had recurrent bronchiolitis no history trauma. In emergency room he was...