A5076494909- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Parvovirus B19 Infection Studies
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Poxvirus research and outbreaks
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Histiocytic Disorders and Treatments
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- RNA regulation and disease
- Hepatitis B Virus Studies
- Forensic and Genetic Research
- Bacteriophages and microbial interactions
- RNA Research and Splicing
Institut Pasteur
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Institut Pasteur de Bangui
2007-2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2013-2024
Conservatoire National des Arts et Métiers
2012-2024
Université Paris Cité
1991-2024
Aix-Marseille Université
2018-2024
Physiopathologie et Epidémiologie des Maladies Respiratoires
2023
Sorbonne Université
1982-2022
Department of Virology
2007-2022
The human T-cell leukemia virus type 1 (HTLV-1), identified as the first oncogenic retrovirus 30 years ago, is not an ubiquitous virus. HTLV-1 present throughout world, with clusters of high endemicity located often nearby areas where nearly absent. main highly endemic regions are Southwestern part Japan, sub-Saharan Africa and South America, Caribbean area foci in Middle East Australo-Melanesia. origin this puzzling geographical or rather ethnic repartition probably linked to a founder...
An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, lethal cases encephalitis. The basis for disease tropism CHIKV remain unknown. Here, we describe replication characteristics recent clinical strains. Human epithelial endothelial cells, primary fibroblasts and, to a lesser extent, monocyte-derived macrophages, were susceptible allowed...
Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa seen increase in frequency of cases, with many monkeypox virus (MPXV) isolates detected Democratic Republic Congo (DRC) and African (CAR). To date, no complete MPXV viral genome been published from human cases identified CAR. The objective this study was sequence full 10 collected during CAR epidemics between 2001 2018 order determine their phylogenetic...
Chikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. Since 2005, the emergence of CHIK was associated with unprecedented magnitude outbreak disease Indian Ocean. Clinically, this characterized invalidating poly-arthralgia, myalgia being reported 97.7% cases. cellular targets are unknown, we studied pathogenic events skeletal muscle.Immunohistology on muscle biopsies from two...
HUMAN T-cell lymphotropic virus Type I (HTLV-I), considered to be the causative agent of adult lymphoma/leukemia,1 , 2 is also associated with a chronic myelopathy (tropical spastic paraparesis) that endemic in Caribbean,3 4 Africa,5 6 7 and South America,8 HTLV-I—associated neuropathy Japan.9 HTLV-I transmitted sexually, chiefly from men women, mother child by breast-feeding, blood transfusion.10 11 In Europe United States, there low prevalence carriers antibody (less than 0.03 percent)...
Human T-cell lymphotropic virus type I (HTLV-I)1 is the etiologic agent of adult leukemia-lymphoma.2 The serum patients with this disease contains antibodies to HTLV-I,3 and there monoclonal integration HTLV-I proviruses in malignant cells.4 principal clinical features leukemia-lymphoma5 are lymphadenopathy, hepatosplenomegaly, skin lesions, hypercalcemia. Compromise immune system can allow opportunistic infection. blood abnormal lymphocytes characteristic indented or convoluted nuclei...
Abstract Tropical spastic paraparesis (TSP) is a common myeloneuropathy with primary and predominant involvement of the pyramidal tract minimal sensory loss. The epidemic form TSP related to toxic nutritional factors, but endemic occurs in clusters tropical areas, especially India, Africa, Seychelles, Colombia, areas Caribbean. We describe clinical epidemiological features 25 patients from Martinique (French West Indies) serum antibodies human T‐lymphotropic virus type I (HTLV‐I)....
We have studied the genetic variation of human T-cell leukemia/lymphoma virus type I (HTLV-I) isolates in same individuals over time, as well HTLV-I from various parts world. The viral DNA fragment encodes carboxy terminus gp46 and almost all gp21, both which are envelope glycoproteins. Samples were obtained native inhabitants five African countries, two South American China, French West Indies, Haiti included 14 patients with tropical spastic paraparesis/HTLV-I-associated myelopathy, 10...
Abstract Human T-cell Leukemia virus type 1 (HTLV-1) and 2 (HTLV-2) are pathogenic retroviruses that infect humans cause severe hematological neurological diseases. Both viruses have simian counterparts (STLV-1 STLV-2). STLV-3 belongs to a third group of lymphotropic which numerous African monkeys species. Among 240 Cameroonian plasma tested for the presence HTLV-1 and/or HTLV-2 antibodies, 48 scored positive by immunofluorescence. those, 27 had indeterminate western-blot pattern. PCR...
In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born HTLV-I-seropositive women was carried out in highly HTLV-I-endemic population African origin living French Guyana. The covered 81 mothers and their 216 aged between 18 months old 12 years old. All plasma samples were tested for presence antibodies by ELISA, immunofluorescence assay...
The pX region of the human T-cell leukemia/lymphotropic virus type I (HTLV-I) contains at least four open reading frames (orfI-orfIV). orf III and IV encode regulatory HTLV-I proteins Rex Tax, which together modulate viral expression, p21rex protein unknown function. By using reverse transcriptase polymerase chain reaction techniques on RNA an HTLV-I-infected cell culture, we uncovered existence alternatively spliced mRNAs generated through use three splice acceptor sites. These encoded...
Two groups of populations with completely different lifestyles-the Pygmy hunter-gatherers and the Bantu-speaking farmers-coexist in Central Africa. We investigated origins these two interactions between them, by analyzing mtDNA variation 1,404 individuals from 20 farming 9 Africa, aim shedding light on one most fascinating cultural transitions human evolution (the transition hunting gathering to agriculture). Our data indicate that this region was colonized gradually, an initial L1c-rich...
The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in last ten millennia. In sub-Saharan Africa, hunter-gatherers have begun shift toward an agriculture-based lifestyle 5,000 years. Only few populations still base their mode subsistence on gathering. Pygmies are considered be largest group mobile Africa. They dwell equatorial rainforests characterized by short mean stature. However, little is known about...
Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)–induced endothelial tumor, develops only in small fraction of individuals infected with HHV-8. We hypothesized that inborn errors immunity to HHV-8 might underlie the exceedingly rare development classic KS childhood. report here autosomal recessive OX40 deficiency an otherwise healthy adult childhood-onset KS. is co-stimulatory receptor expressed on activated T cells. Its ligand, OX40L, various cell types, including found...
Human infection by simian foamy viruses (SFV) can be acquired persons occupationally exposed to non-human primates (NHP) or in natural settings. This study aimed at getting better knowledge on SFV transmission dynamics, risk factors for such a zoonotic and, searching intra-familial dissemination and the level of peripheral blood (pro)viral loads infected individuals. We studied 1,321 people from general adult population (mean age 49 yrs, 640 women 681 men) 198 individuals, mostly men, all...