A5050247627- Sleep and related disorders
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Cytomegalovirus and herpesvirus research
- Obesity, Physical Activity, Diet
- Viral-associated cancers and disorders
- Infant Development and Preterm Care
- Child Nutrition and Feeding Issues
- T-cell and Retrovirus Studies
- Parvovirus B19 Infection Studies
- Animal Disease Management and Epidemiology
- Circadian rhythm and melatonin
- Vector-Borne Animal Diseases
- Herpesvirus Infections and Treatments
- Obstructive Sleep Apnea Research
- Birth, Development, and Health
- Child Development and Digital Technology
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Hepatitis C virus research
- Early Childhood Education and Development
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
Université Paris Cité
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Inserm
2016-2025
Sorbonne Paris Cité
2013-2025
Université Sorbonne Paris Nord
2023-2025
Sorbonne Université
2001-2025
Centre National de la Recherche Scientifique
2009-2025
Centre de Recherche en Neurosciences de Lyon
2020-2025
Université Claude Bernard Lyon 1
2023-2025
Centre de Recherche Épidémiologie et Statistique
2015-2024
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution host defense natural ecosystems is unknown. We report a dominant-negative TLR3 allele otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis. expressed the central nervous system (CNS), where it required control HSV-1, which spreads from epithelium CNS via cranial nerves. also epithelial dendritic cells, apparently use TLR3-independent pathways...
Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral in western countries. Its pathogenesis remains unclear, as it affects otherwise healthy patients and only a small minority HSV-1-infected individuals. Here, we elucidate genetic etiology for HSE two children with autosomal recessive deficiency intracellular protein UNC-93B, resulting impaired cellular interferon-alpha/beta -lambda antiviral responses. can result from single-gene immunodeficiency that...
Autosomal dominant TLR3 deficiency has been identified as a genetic etiology of childhood herpes simplex virus 1 (HSV-1) encephalitis (HSE). This defect is partial, it results in impaired, but not abolished induction IFN-β and -λ fibroblasts response to stimulation. The apparently normal resistance these patients other infections, viral illnesses particular, may thus result from residual responses. We report here an autosomal recessive form complete young man who developed HSE remained...
Herpes simplex encephalitis (HSE) is the most common sporadic viral of childhood. Autosomal recessive (AR) UNC-93B and TLR3 deficiencies autosomal dominant (AD) TRAF3 underlie HSE in some children. We report here unrelated children with AR or AD TRIF deficiency. The form disease was found to be due a homozygous nonsense mutation that resulted complete absence protein. Both TLR3- TRIF-dependent TLR4 signaling pathways were abolished. heterozygous missense mutation, resulting dysfunctional In...
Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basin, despite high prevalence of human herpesvirus-8 (HHV-8) infection this region. We hypothesized that single-gene inborn errors immunity to HHV-8 may underlie classic KS childhood. investigated a child with no other unusually severe infectious or tumoral phenotype who died disseminated at two years age. Whole-exome sequencing patient revealed homozygous splice-site mutation STIM1, gene encoding stromal...
While in the United States and northern Europe, human herpesvirus 8 (HHV-8) appears to be mainly sexually transmitted with primary infection occurring adulthood, modes of transmission remain unknown East Central Africa, where Kaposi's sarcoma (KS) is a long-standing endemic disease, not only adults but also children. The aim our present study was determine prevalence HHV-8 children from Yaoundé, Cameroon, Africa. Specific antibodies directed against both latent lytic antigens were detected...
Merkel cell polyomavirus (MCPyV) is thought to be the etiological agent of carcinoma, but little known about its distribution and modes transmission. We conducted seroepidemiological surveys in more than 1000 individuals, from two populations Cameroon. Overall MCPyV seroprevalence was high both (>75% adults). Data first population, comprising mainly children, indicated that infections mostly occurred during early childhood, after disappearance specific maternal antibodies. Results second...
Night shift work has been associated with an increased risk of breast cancer pointing to a role circadian disruption. We investigated the clock gene polymorphisms and their interaction nightwork in population-based case–control study France including 1126 cases 1174 controls. estimated each 577 single nucleotide (SNPs) 23 genes. also used gene- pathway-based approach investigate overall effect on variants that might not be detected analyses based individual SNPs. Interactions were tested at...
Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject environmental factors, particularly light exposure and food intake rhythms. However, association between nutritional behaviours cancer not well understood. We investigated longitudinal associations number of eating episodes, night-time fasting duration, time first last quality episode, respectively, with...
Abstract Background Host genetic factors may play a role in susceptibility and resistance to SARS associated coronavirus (SARS-CoV) infection. The study was carried out investigate the association between polymorphisms of 2',5'-oligoadenylate synthetase 1 (OAS1) gene as well myxovirus (MxA) Chinese Han population. Methods A hospital-based case-control conducted. collective 66 cases 64 close contact uninfected controls were enrolled this study. End point real time polymerase chain reaction...
Rhinoscleroma (RS) is a rare, chronic, granulomatous disease of the upper respiratory tract that associated with infection Klebsiella rhinoscleromatis. RS more common in certain geographic regions than others, but other risk factors and pathogenesis remain unclear.We sent standardized questionnaire to all pathologists otolaryngology specialists French University Hospitals asked whether they had seen patients previous 16 years (1990-2005). We then retrospectively reviewed files identified.We...
Abstract Studies in children have reported associations of screen time and background TV on language skills as measured by their parents. However, few large, longitudinal studies examined assessed trained psychologists, which is less prone to social desirability. We exposure during family meals at ages 2, 3 5–6 years 1562 from the French EDEN cohort. Language were evaluated parents 2 (Communicative Development Inventory, CDI) psychologists (NEPSY ELOLA batteries) (verbal IQ). Cross-sectional...
Retracing the genetic histories of descendant populations Slave Trade (16th-19th centuries) is particularly challenging due to diversity African ethnic groups involved and different hybridisation processes with Europeans Amerindians, which have blurred their original inheritances. The Noir Marron in French Guiana are direct descendants maroons who escaped from Dutch plantations current day Surinam. They represent an group a highly blended culture. Uniparental markers (mtDNA NRY) coupled...
Background. The presence and origin of endemic foci human T-lymphotropic virus type 2 (HTLV2) infection in Africa remain a matter debate.
Summary Total sleep duration has been decreasing among children in the last decades. Short ( SSD ) associated with deleterious health consequences, such as excess weight/obesity. Risk factors for have already studied school‐aged and adolescents, but inconsistent results reported regarding possible gender differences. Studies reporting relationships are scarce preschoolers, despite importance of this period adopting healthy behaviour. We aimed to investigate 3‐year‐old boys n = 546) girls...