A5079105601- Air Quality and Health Impacts
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Veterinary Equine Medical Research
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Hip disorders and treatments
- Atmospheric chemistry and aerosols
- Urban Green Space and Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Urban Transport and Accessibility
- Genetic Associations and Epidemiology
- Urban Heat Island Mitigation
- Vehicle emissions and performance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Global Health Care Issues
- Child Nutrition and Water Access
- Pregnancy and preeclampsia studies
- Animal health and immunology
Centre National de la Recherche Scientifique
2016-2025
Université Grenoble Alpes
2016-2025
Institut pour l'avancée des biosciences
2016-2025
Inserm
2016-2025
Institut de Biosciences et Biotechnologies
2019-2024
Université Paris Cité
2024
Médecins du Monde
2024
Keio University
2023
Centre Hospitalier Universitaire de Grenoble
2014-2022
University of California, Berkeley
2022
Epidemiologic studies have reported associations between fine particles (aerodynamic diameter ≤ 2.5 µm; PM2.5) and mortality. However, concerns been raised regarding the sensitivity of results to model specifications, lower exposures, averaging time.
Background: A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent.Objectives: We aimed quantify association between particulate and term birth weight low (LBW) across 14 centers from 9 countries, explore influence site characteristics assessment methods between-center heterogeneity in this association.Methods: Using a common analytical protocol, International Collaboration Air...
Gene-environment association (GEA) studies are essential to understand the past and ongoing adaptations of organisms their environment, but those complicated by confounding due unobserved demographic factors. Although problem has recently received considerable attention, proposed approaches do not scale with high-dimensionality genomic data. Here, we present a new estimation method for latent factor mixed models (LFMMs) implemented in an upgraded version corresponding computer program. We...
The mechanisms by which air pollution has multiple systemic effects in humans are not fully elucidated, but appear to include inflammation and thrombosis. This study examines whether concentrations of ozone components fine particle mass associated with changes methylation on tissue factor (F3), interferon gamma (IFN-γ), interleukin 6 (IL-6), toll-like receptor 2 (TLR-2), intercellular adhesion molecule 1 (ICAM-1). We investigated associations between exposure gene-specific 777 elderly men...
Few studies have been performed on pulmonary effects of air pollution in the elderly--a vulnerable population with low reserve capacity--and mechanisms and susceptibility factors for potential are unclear.We evaluated lag structure pollutant associations lung function effect modification by DNA methylation (< or ≥ median) at 26 individual CpG sites nine candidate genes a well-characterized cohort elderly men.We measured forced vital capacity (FVC), expiratory volume 1 sec (FEV1), blood one...
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying mechanisms. We investigated association between more than 100 exposures assessed during pregnancy in childhood (including indoor outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, biomarkers chemical pollutants), epigenetic age acceleration 1,173 children aged 7 years old from Human Early-Life Exposome project. Age was...
The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA levels and gene expression, might help the biological interpretation epigenome-wide association studies (EWAS). We aimed to identify autosomal cis eQTMs in children's blood, using data from 832 children Human Early Life Exposome (HELIX) project.
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years. Method: Data from 1,759 belonging to HELIX project cohorts Asturias, Gipuzkoa Valencia of INMA were included. TL was determined by blood sample using a PCR protocol. ADHD described parents Conners’ Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders used estimate...
Background: Epidemiologic studies have reported associations between air pollution levels and semen characteristics, which might in turn affect a couple's ability to achieve live birth. Our aim was characterize short-term effects of atmospheric pollutants on fecundability (the month-specific probability pregnancy among noncontracepting couples). Methods: For cohort births 1994 1999 Teplice (Czech Republic), we averaged fine particulate matter (PM2.5), carcinogenic polycyclic aromatic...
Few studies have been performed on air pollution effects lung function in the elderly, a vulnerable population with low reserve capacity, and even fewer looked at changes rate of decline.We evaluated effect long-term exposure to black carbon levels rates decline elderly.FVC FEV1 were measured one six times during period 1995-2011 858 men participating Normative Aging Study. Exposure carbon, tracer traffic emissions, was estimated by spatiotemporal land use regression model. We investigated...
Multicentre studies are common in epidemiological research aiming at identifying disease risk factors. A major advantage of multicentre over single-centre is that, by including a larger number participants, they allow consideration rare outcomes and exposures. Their multicentric nature introduces some complexities the step data analysis, particular when it comes to controlling for confounding centre, which focus this tutorial. Commonly, epidemiologists use one following options: pooling all...
The association between air pollution exposure and emotional behavioural problems in children is unclear. We aimed to assess prenatal postnatal several pollutants child's depressive anxiety symptoms, aggressive symptoms of 7–11 years. analysed data 13182 from 8 European population-based birth cohorts. Concentrations nitrogen dioxide (NO2), oxides (NOx), particulate matter (PM) with diameters ≤10 μm (PM10), ≤ 2.5 (PM2.5), 10 (PMcoarse), the absorbance PM2.5 filters (PM2.5abs), polycyclic...