A5007106467- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Vitamin D Research Studies
- Telomeres, Telomerase, and Senescence
- Maternal Mental Health During Pregnancy and Postpartum
- Heavy metals in environment
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infant Development and Preterm Care
- Cancer and Skin Lesions
- Inflammatory Myopathies and Dermatomyositis
- Aging, Health, and Disability
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Dermatological and Skeletal Disorders
- Cardiovascular Health and Risk Factors
- Environmental Justice and Health Disparities
- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Heterotopic Ossification and Related Conditions
- Fatty Acid Research and Health
Hospital San Agustin
2014-2025
Instituto de Investigación Sanitaria del Principado de Asturias
2021-2025
Background: Natural environments, including green spaces, may have beneficial impacts on brain development. However, longitudinal evidence of an association between long-term exposure to spaces and cognitive development (including attention) in children is limited. Objectives: We evaluated the lifelong residential space attention during preschool early primary school years. Methods: This study was based data from two well-established population-based birth cohorts Spain. assessed surrounding...
Objective To investigate the association of maternal circulating 25‐hydroxyvitamin D3 [25( OH )D3] concentration with pregnancy and birth outcomes. Design Prospective cohort study. Setting Four geographical areas Spain, 2003–2008. Population Of 2382 mother–child pairs participating in IN fancia y Medio Ambiente ( INMA ) Project. Methods Maternal 25( )D3 was measured (mean [ SD ] 13.5 [2.2] weeks gestation). We tested associations Main outcome measures Gestational diabetes mellitus GDM ),...
Background: Vitamin D status during prenatal brain development may influence risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. However, there are no prospective studies addressing this hypothesis. We aimed to examine whether maternal vitamin pregnancy is associated with ADHD-like offspring. Methods: conducted a study analyzing data from 1,650 mother–child pairs five birth cohorts embedded the INMA Project (Spain, 1997–2008). Maternal was estimated by...
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years. Method: Data from 1,759 belonging to HELIX project cohorts Asturias, Gipuzkoa Valencia of INMA were included. TL was determined by blood sample using a PCR protocol. ADHD described parents Conners’ Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders used estimate...
Abstract Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed assess the association between maternal vitamin 3 , major circulatory form D, at pregnancy and neurodevelopmental outcomes childhood, namely: behavioural problems, Attention Deficit Hyperactivity Disorder (ADHD) Autism Spectrum (ASD) symptoms, social competence. This study included 2,107 mother-child pairs a Spanish population-based birth cohort. Maternal plasma was...
Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As of particular concern among pregnant women, infants and children, as they are specifically vulnerable the effects i-As, in utero early-life exposure, even low moderate levels may have marked effect throughout lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used analyse urinary speciation, an exposure biomarker, samples...
Exposure to toxic and non-toxic metals impacts childhood growth development, but limited data exists on exposure metal mixtures. Here, we investigated the effects of individual a mixture barium, cadmium, cobalt, lead, molybdenum, zinc, arsenic indicators in children 4-5 years age.We used urine concentrations as biomarkers 328 enrolled Spanish INMA-Asturias cohort. Anthropometric measurements (arm, head, waist circumferences, standing height, body mass index) parental sociodemographic...
To determine lipid profiles in early childhood and evaluate their association with weight status at 4 years of age. Additionally, we evaluated whether the risk overweight or having an altered profile was associated parental status.Five hundred eighty two mothers 4-year-old children from 2 Spanish population-based cohorts were studied. Weight age classified as obese using International Obesity Task Force criteria. Plasma total cholesterol, triglycerides, high-density lipoprotein low-density...
Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) a sensitive biomarker of prenatal androgen antiandrogen exposure. We investigated the effect smoking passive smoke exposure during on anogenital in offspring at 4 years INMA-Asturias cohort (Spain). Women were interviewed collect information tobacco consumption, was measured 381 children:...
Aim This study aimed to investigate whether there are subgroups of children with different clusters cardiovascular disease (CVD) risk factors at 4 and 8 years age, their patterns change between these two time points. Methods The analysis was conducted in 332 who participated the INMA-Asturias cohort (Spain) age. CVD were central obesity, dyslipidaemia, hyperglycaemia, hypertension. Latent transition used identify probabilities change. Results At years, three identified: no disorders...
Focal dermal hypoplasia (FDH) is a rare multisystem disorder characterized by abnormalities in tissues derived from the meso-ectoderm, mainly affecting skin, eyes, teeth and skeleton. We present case of young girl with FDH due to de novo mutation c.1061T>C (p.Leu354Pro) PORCN gene, responsible for defects bone, skeleton, heart, maxillary anus/rectum malformation. At birth, an infectious etiology cutaneous syndromes that produce similar skin lesions were ruled out. Clinical manifestations led...
Identifying cardiovascular-related measures that track from early childhood into later ages may help inform prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to height ratio (WC/Height), mean arterial pressure (MAP), and homeostatic model assessment insulin resistance (HOMA-IR) was examined in INMA-Asturias cohort between 4 8 years age. The analysis conducted...