A5009943472- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Mast cells and histamine
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Drug-Induced Adverse Reactions
- Pediatric health and respiratory diseases
- interferon and immune responses
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tuberculosis Research and Epidemiology
- Actinomycetales infections and treatment
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Myxozoan Parasites in Aquatic Species
- Chronic Lymphocytic Leukemia Research
King Saud University
2013-2024
King Abdullah International Medical Research Center
2023
National Guard Health Affairs
2023
King Saud bin Abdulaziz University for Health Sciences
2023
King's College London
2023
Riyadh Armed Forces Hospital
2019
King Khalid University Hospital
2008-2012
University of Southampton
2008-2011
National Hospital
2010
Children's Hospital of Chongqing Medical University
2010
Interleukin-12 receptor β1 (IL-12Rβ1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an international survey 141 patients from 102 kindreds in 30 countries. Among probands, first infection occurred at a mean age 2.4 years. In 78 patients, this was caused by Bacille Calmette-Guérin (BCG; n = 65), environmental mycobacteria (EM; also known as atypical or nontuberculous mycobacteria) (n 9) Mycobacterium tuberculosis 4). Twenty-two...
Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous autosomal recessive immune disorder characterized by the occurrence of uncontrolled activation lymphocytes and macrophages infiltrating multiple organs. Disease-causing mutations in perforin (PRF1; also known as FHL2), Munc13-4 (UNC13D; FHL3), syntaxin-11 (STX11; FHL4) genes have been identified individuals with FHL. These all encode proteins involved cytotoxic activity lymphocytes. Here, we show that gene...
Herpes simplex encephalitis (HSE) is the most common sporadic viral of childhood. Autosomal recessive (AR) UNC-93B and TLR3 deficiencies autosomal dominant (AD) TRAF3 underlie HSE in some children. We report here unrelated children with AR or AD TRIF deficiency. The form disease was found to be due a homozygous nonsense mutation that resulted complete absence protein. Both TLR3- TRIF-dependent TLR4 signaling pathways were abolished. heterozygous missense mutation, resulting dysfunctional In...
Deficiency of ubiquitin-specific peptidase 18 (USP18) is a severe type I interferonopathy. USP18 down-regulates interferon signaling by blocking the access Janus-associated kinase 1 (JAK1) to receptor. The absence results in unmitigated interferon-mediated inflammation and lethal during perinatal period. We describe neonate who presented with hydrocephalus, necrotizing cellulitis, systemic inflammation, respiratory failure. Exome sequencing identified homozygous mutation at an essential...
To characterize the features of cold urticaria in children, with particular focus on systemic reactions, because little pediatric data are available.Chart reviews 30 children <18 years old who were evaluated past 3 at Children's Hospital Allergy Program (Boston, MA) and a private allergy practice. Demographic, diagnostic, therapeutic collected. Telephone interviews patients and/or their parents performed to obtain follow-up data.Our showed that mean median ages onset approximately 7 years....
Glucocorticoids are the mainstay of asthma therapy. They primarily used to suppress airway inflammation, which is central pathological change in asthmatic patients' airways. This achieved by many different mechanisms. The classical mechanism suppression genetic transcription inflammatory cytokines that key pathophysiology (transrepression). On other hand, certain inhibitory activated glucocorticoids (transactivation), a also mediates adverse effects glucocorticoids. onset action through...
IFN- γ has been used in the treatment of IL-12R β 1 deficiency patients with disseminated BCG infection (BCGosis), but optimal dose to reach efficacy is not clear. We a 2.7-year-old patient and refractory BCG-osis. IFN was started at 50 μ g/m 2 3 times per week. The upgraded 100 mcg/m after months, then 200 6 months afterwards. Serum mycobactericidal activity lymphocytes number function were evaluated throughout study. There no clinical response or doses. However, there some additional...
Introduction As manuka honey (MH) exhibits immunoregulatory and anti-staphylococcal activities, we aimed to investigate if it could be effective in the treatment of atopic dermatitis (AD). Methods Adult volunteers with bilateral AD lesions were asked apply MH on one site overnight for seven consecutive days leave contralateral untreated as possible. Three Item Severity score was used evaluate response. Skin swabs obtained from both sites before after presence staphylococci enterotoxin...
BackgroundInhaled corticosteroids, known to be effective as a maintenance medication in chronic asthma, have also been suggested therapy for acute asthma when given at high doses.MethodsA double-blind, randomized, placebo-controlled trial was conducted children aged 2 12 years with moderate or severe determined based on clinical score of 5 15 points, where is the most severe. We compared addition budesonide 1,500 μg vs placebo standard treatment, which included salbutamol, ipratropium...
Alternative medicine is defined as medical therapies that are not regarded orthodox by the profession. The teaching of complementary and alternative (CAM) in schools becoming prevalent worldwide. Only a few studies have been done to assess students' attitude toward CAM need for courses.An observational, descriptive, cross-sectional study was conducted on students two universities, King Saud (KSU) Majmaah (MU) colleges, between February April 2015. A survey developed validated pilot study....
Manuka honey (MH) is a complex nutritional material with antimicrobial, antioxidant and anti-inflammatory activity. We have previously shown that MH down regulates IL-4-induced CCL26 expression in immortalized keratinocytes. As contains potential ligands of the Aryl Hydrocarbon Receptor (AHR), key regulator skin homeostasis, we hypothesize this effect mediated via AHR activation. Here, treated HaCaT cell lines, either stable transfected an empty vector (EV-HaCaT) or which had been silenced...
BACKGROUND AND OBJECTIVES:Genetic association studies have demonstrated that over 100 variants in target genes (including ADAM33) are associated with airway remodeling and hyper-responsiveness different ethnic groups; however, this has never been evaluated Arabic populations.The objective of study was to determine whether ADAM33 polymorphisms asthma a population asthmatic children from Saudi Arabia. DESIGN SETTING:A cross-sectional pilot comparing the normal subjects patients Arabia period 1...
CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Distinct homozygous mutations in CBLB were identified 3 unrelated children with early-onset autoimmunity, one whom also had chronic urticaria. Patient T cells exhibited hyperproliferation response anti-CD3 cross-linking. One the mutations, p.R496X, abolished expression, and a second mutation, p.C464W, resulted preserved expression. The third p.H285L SH2...
Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive metabolic disorder that results in combined immunodeficiency, neurologic dysfunction and autoimmunity. PNP has never been reported from Saudi Arabia or patients with an Arabic ethnic background. We report on two girls deficiency. Both showed severe lymphopenia neurological involvement. Sequencing of the gene one girl revealed novel missense mutation Pro146>Leu exon 4 due to change codon CCT>CTT. Expression (146L)...
True allergic reactions to local anesthetics are extremely rare and constitute less than 1% of all reactions. In addition, many those caused by the preservative constituents anesthetics. Here we report a 12 year old girl with anaphylaxis lidocaine (an amide anesthetic) on two occasions. The allergy was confirmed positive skin prick test drug. Skin testing challenge another anesthetic (articaine) were negative. Subsequently, its use well tolerated in dental procedure. Up our knowledge, this...
Gastrointestinal basidiobolomycosis (GIB), caused by Basidiobolus ranrum, is a rare fungal infection with limited geographic distribution. The majority of the cases are reported from warm areas Arizona in USA, Saudi Arabia and Iran. We report middle aged patient who was admitted to hospital suspected metastatic colonic carcinoma. He presented constipation, anorexia weight loss. Computed tomography scan disclosed mass involving mid distal sigmoid colon hypodense lesion hepatic segment IV....