A5055202423- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Brucella: diagnosis, epidemiology, treatment
- Immunodeficiency and Autoimmune Disorders
- Infections and bacterial resistance
- Viral gastroenteritis research and epidemiology
- Pleural and Pulmonary Diseases
- Burkholderia infections and melioidosis
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Mycobacterium research and diagnosis
- Parvovirus B19 Infection Studies
- Antibiotic Resistance in Bacteria
- Diagnosis and treatment of tuberculosis
- Coronary Artery Anomalies
- Respiratory viral infections research
- Amoebic Infections and Treatments
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Parasitic infections in humans and animals
- Congenital Diaphragmatic Hernia Studies
Ministry of Health
2015-2024
Sağlık Bilimleri Üniversitesi
2017-2024
Gazi University
2024
Mersin Üniversitesi
2024
Children's Research Hospital
2023
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2010-2022
Health and Human Development (2HD) Research Network
2022
Office of Infectious Diseases
2022
Pediatrics and Genetics
2021-2022
Pediatric Infectious Diseases Society
2017-2020
Interleukin-12 receptor β1 (IL-12Rβ1) deficiency is the most common form of Mendelian susceptibility to mycobacterial disease (MSMD). We undertook an international survey 141 patients from 102 kindreds in 30 countries. Among probands, first infection occurred at a mean age 2.4 years. In 78 patients, this was caused by Bacille Calmette-Guérin (BCG; n = 65), environmental mycobacteria (EM; also known as atypical or nontuberculous mycobacteria) (n 9) Mycobacterium tuberculosis 4). Twenty-two...
Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rβ1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, mucocutaneous candidiasis. Susceptibility to these infections is thought be due impairments IL-12-dependent IFN-γ immunity and IL-23-dependent IL-17A/IL-17F immunity, respectively. We report here IL-12Rβ2 IL-23R deficiency, lacking responses IL-12 IL-23 only, all whom, unexpectedly, display...
Background and Objectives In the last decade, autosomal recessive IL-12Rβ1 deficiency has been diagnosed in four children with severe tuberculosis from three unrelated families Morocco, Spain, Turkey, providing proof-of-principle that otherwise healthy may result single-gene inborn errors of immunity. We aimed to estimate fraction developing due areas endemic for where parental consanguinity is common. Methods Principal Findings searched IL12RB1 mutations a series 50 Iran, Turkey. All had...
Brucellosis constitutes a public health problem in Turkey. In endemic Brucella melitensis areas such as Turkey, children represent 20-25% of cases.Hospital records 90 with brucellosis admitted during 9 year period, 1997-2006, were evaluated retrospectively.Of patients, 27 (30%) female and 63 (70%) male (P < 0.05). Patients aged between 1 16 years age. The mean age was 9.02 +/- 3.59 years. Fifty-two patients (57.8%) from rural mode transmission consumption unpasteurized milk products 64...
Interleukin 12Rβ1 (IL-12Rβ1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon γ production. About 25% also display mucocutaneous candidiasis, owing 23-dependent 17 immunity. The features outcome candidiasis in these have not been described before, our knowledge. We report here the signs 35 with IL-12Rβ1 deficiency.Most (n = 71) 76 episodes were...
Abstract Determination of the etiology bacterial meningitis and estimating cost disease are important in guiding vaccination policies. To determine incidence Turkey, cerebrospinal fluid (CSF) samples were obtained prospectively from children (1 month–17 years age) with a clinical diagnosis acute meningitis. Multiplex PCR was used to detect DNA evidence Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), Neisseria meningitidis. In total, 408 CSF collected, determined 243 cases; N....
Two randomized controlled clinical trials have shown that Lactobacillus (L) reuteri DSM 17938 reduces the duration of diarrhea in children hospitalized due to acute infectious diarrhea. This was first trial evaluating efficacy L. outpatient with diarrhea.This a multicenter, randomized, single-blinded, case control watery A total 64 who presented at clinics were enrolled. The probiotic group received 1×10(8)CFU for five days addition oral rehydration solution (ORS) and second treated ORS...
The pathophysiology of multisystem inflammatory syndrome (MIS) in children (MIS-C) is unknown. It occurs several weeks after COVID-19 infection or exposure; however, MIS rarely reported vaccination, and cases are mostly adults. Herein, we present a 12-year-old male who had no prior exposure developed MIS-C his first dose mRNA vaccine.
Evidence from the literature has shown that Saccharomyces boulardii provides a clinically significant benefit in treatment of acute infectious diarrhoea children. In this multicentre, randomised, prospective, controlled, single blind clinical trial performed children with watery diarrhoea, we aimed to evaluate impact S. CNCM I-745 hospitalised children, requiring emergency care unit (ECU) stay and outpatient settings. The primary endpoint was duration (in hours). Secondary outcome measures...
Abstract Background Kawasaki disease (KD) may cause cardiac and coronary complications. Since definite markers to accurately predict involvement is not present, we aimed analyze the role of hematological indices [neutrophil-to lymphocyte ratio (NLR), platelet-to (PLR), lymphocyte-to monocyte (LMR), mean platelet volume (MPV)-to (MPVLR)], prognostic nutritional index (PNI) systemic immune-inflammation (SII) in predicting KD. Patients The medical records 134 KD patients admitted between...
Abstract Background Antibiotic-associated diarrhea is one of the most frequent side effects antimicrobial therapy. We assessed epidemiological data antibiotic-associated in pediatric patients our region. Methods The prospective multi-center study included who were initiated an oral antibiotic course outpatient clinics and followed a well-established surveillance system. This follow-up system constituded inclusion patient by primary physician, supply family charts to family, passing...
Comamonas testosteroni has been rarely observed as an infectious agent in clinical practice.The organism the low virulence potency and infrequently causes human disease.Comamonas species (previously classified within Pseudomonas group) have widespread environmental distribution also survive for a long time hospital environments (1, 2).We present previously healthy adolescent with localised peritonitis complication of perforated appendicitis associated polymicrobial aetiology including C....
Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, therapeutic approach SA in children Turkiye, emphasizing role real-time polymerase chain reaction (PCR) techniques diagnosis. Methods: In multi-center, prospective study, hospitalized due between February 2018 July...
The aim of the present study was to identify epidemiological, clinical and laboratory features Crimean-Congo hemorrhagic fever (CCHF) virus infection in children.Fifty children infected with CCHF 2005-2010, hospitalized Dr Sami Ulus Maternity Children's Health Diseases Training Research Hospital Ankara, were included. All patients had positive IgM and/or polymerase chain reaction for virus.Of 50 patients, 19 female 31 male. Patients between 8 months 15 years age. majority (82%) a history...
Background: In April 2009 a novel strain of human influenza A, identified as H1N1 virus, rapidly spread worldwide, and in early June the World Health Organization raised pandemic alert level to phase 6. Herein we present largest series children who were hospitalized due infection Turkey. Methods: We conducted retrospective multicentre analysis case records involving with influenza-like illness, whom was diagnosed by reverse-transcriptase polymerase chain reaction assay, at 17 different...
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis with the potential of human-to-human transmission that affects wide areas in Asia, Southeastern Europe, and Africa. Hemorrhagic manifestations constitute prominent symptom late stage disease case fatality rates from 3 to 50%. We present CCHF complicated by pleural effusion resulting resolution without chest tube drainage 9-year-old boy. The diagnosis was confirmed enzyme-linked immunosorbent assay tests. Both serum fluid...
Aim Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection may result in a life‐threatening hyperinflammatory condition named multisystem inflammatory children (MIS‐C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS‐C. Methods performed retrospective study MIS‐C managed between August 2020 March 2021 at Dr. Sami Ulus Maternity Child Health Diseases Training Research Hospital Turkey. Results A...