A5067678529- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- AI in cancer detection
- Teratomas and Epidermoid Cysts
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- Head and Neck Surgical Oncology
- HER2/EGFR in Cancer Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Prostate Cancer Treatment and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Meningioma and schwannoma management
- Prostate Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Musculoskeletal synovial abnormalities and treatments
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
Istanbul Medipol University
2016-2025
Dokuz Eylül University
2016-2024
Gebze Technical University
2024
Sağlık Bilimleri Üniversitesi
2024
University of Health Science
2024
Istanbul University
1993-2019
Gazi University
2008-2014
Sivas State Hospital
2011-2013
State Hospital
2012
Abstract Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation multinational settings. Competitions be accelerators medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this mind, we organized the PANDA challenge—the largest histopathology competition date, joined 1,290 developers—to catalyze development...
The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability. Artificial intelligence (AI) systems based on deep learning can achieve pathologist-level performance at grading. However, of such degrade in presence artifacts, foreign tissue, or other anomalies. Pathologists integrating their expertise with feedback an AI system could result a synergy that outperforms both individual pathologist and system. Despite...
There are virtually no data in the literature regarding incidence, patterns, and clinicopathologic characteristics of mucinous carcinomas (MCs) gallbladder (GB).To determine incidence differentiation invasive GB those that qualify as MC.Primary (n = 606) were reviewed for differentiation. Some degree mucin production was identified 40 cases (6.6%); however, only 15 (2.5%) qualified World Health Organization definition MC (stromal deposition constituting >50% tumor).The mean age 65 years,...
We describe a clinicopathologically distinct subtype of cholecystitis, the extensively calcific version which has been presented in clinical literature as "porcelain gallbladder (PG)." This we propose to refer hyalinizing cholecystitis (HC), is characterized by dense, paucicellular hyaline fibrosis transforming (GB) wall into relatively thin and uniform band. The process diffusely effaces most normal structures GB, some cases show calcifications. To determine clinicopathologic associations...
Abstract High grade gliomas (grade III and IV) including glioblastomas (GBM, IV, IDH wild type), are highly aggressive brain tumors with limited treatment options poor prognosis. Tumor recurrence is inevitable standard methods surgical debulking, radio- chemotherapies. For this reason, a broad range of studies focus on the discovery diagnostic therapeutic markers to cure malign disease. SLC3A2, polyamine transporter, has been implicated in chemoresistance identified as prognostic marker...
Background/Objectives: The goal of this study is to characterize the survival patterns and outcomes women with early-stage breast cancer, a particular emphasis on distinction between HER2-low HER2-zero expression. There limited real-world data how patients HER2-negative or metastatic recurrent cancer are treated. Methods: We retrospectively analyzed medical records 1500 diagnosed January 2020 December 2024. From cohort, 99 34 were included in our analysis. HER2 low was defined as...
Amaç: Kardiyak kitleler nadirdir, neoplastik ve nonneoplastik olarak ayrılmaktadır. Bu makalenin amacı kardiyak kitlelere genel bir bakış sağlamak klinikopatolojik özelliklerini gözden geçirmektir Materyal Metodlar: Merkezimizde 2014-2022 yılları arasında kitle nedeniyle opere edilen 35 vakayı retrospektif inceledik. Bulgular: Vakaların yaşları 7 ay ile 79 yıl değişmektedir (ortalama yaş 46,2 yıl) 25’i kadındır. Serimizin büyük kısmını primer benign kalp tümörleri oluşturmaktadır en sık...
Breast carcinomas can be classified into five subtypes based on gene expression profiling or immunohistochemical characteristics. Among these subtypes, basal-like breast (BLBCs) are one of the most studied group, due to their poor prognosis. The aim this study was investigate prevalance, morphological and features BLBCs, in Turkish population. Five hundred invasive were reviewed for several immunostained oestrogen progesterone receptors, c-ERB-B2, cytokeratin5/6, cytokeratin14, vimentin...
Objectives The aims of this study are to evaluate expressions Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed affect prognosis in literature correlate results clinicopathological parameters breast cancer patients. Methods RacGAP1, TOP2a antibodies were applied immunohistochemically tissue micrarray blocks 457 female correlated clinical, prognostic, histopathological features, other immunohistochemical findings...
Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in lung. In context of cancer, IL-33-activated were found to bear anti-tumoral functions lung cancer promoted tumorigenesis colorectal cancer. The role remains addressed.We examined overall survival human non-small cell (NSCLC) patients according IL25 expression as well...
Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the significance metastatic lymph ratio (MLNR) and compare it number metastasis pN3 cancer.We retrospectively analyzed 207 cancer who had undergone radical gastrectomy. Prognostic factors MLNR were evaluated by univariate multivariate analysis.An 0.75 found be best cut-off value prognosis (p = 0.001). significantly higher large-sized undifferentiated tumors,...
Abstract Background: In support of Project LUNGMARK, LUNGBANK was established as a pioneering biorepository dedicated to lung cancer. Designed for streamlined biospecimen handling, it employs high-volume technologies secure high-quality samples. Fortified with robust data management, efficiently integrates diverse datasets. This strategic infrastructure positions more than repository; operates sophisticated platform advanced cancer research, amplifying the potential meaningful discoveries....
Cervical carcinoma is one of the frequently seen cancers in world and our country, develops from precursor lesions. These lesions are analyzed by pathologists so that diagnosis disease can be made. In this study, a system performs automatic detection pre-cancerous was performed using convolutional neural networks (CNNs). training phase, lesion recognition performance proposed has reached 92%. Thereafter, whole image segmented 60 × pixel tiles during phase. After all, were with 81.71% Dice...
Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 primary tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed concordance on cells and infiltrating lymphocytes (TILs) CD8+ TIL intensity between tumors BMs from 24 NSCLC patients. PD-L1, CD3, CD8 positivity was determined by immunohistochemistry (IHC). scoring based proportion...
A subungual exostosis (SE) is a bony overgrowth that permanently attached to the tip of distal phalanx. Its pathology differs from osteocartilaginous exostoses in it mainly involves normal bone, which may present beneath toenail or on sides toe. This retrospective study aimed report results surgical treatment when diagnosis SE was delayed; condition initially considered be another affecting different nail terminal toe.A total 17 patients (12 female, five male) were included study. All...
Surgical excisional biopsy is accepted as the standard of care approach in diagnosis lympho- mas. Financial issues related to increased cost and invasive nature procedure forced physicians use some alternative diagnostic methods. Percutaneous core needle biopsy, which gained a reputation for lymphomas with advent improved pathological, immunohistochemical, molecular analysis, made it possible have an accurate limited tissue samples. In this retrospective study, we aimed compare yield...
Prostate adenocarcinoma is the most common malignancy and second leading cause of cancer related deaths in men. Testicular liposarcomas are uncommon soft tissue neoplasms. We report coexistence prostate testicular liposarcoma a 69 year-old-man because while orchiectomy endications decreasing day by day, these malignancies should not be missed.
Schistosomiasis is a rare condition in Turkey but remains second most prevelant parasitic infestation worldwide.A 67-years old male patient admitted to hospital with macroscopic hematuria. Bladder tumor was diagnosed and referred our department for the treatment. Transurethral resection of bladder performed pathological examination revealed high-grade papillary urothelial carcinoma Schistosoma mansoni eggs. The used praziquantel 40mg orally treatment intravesical immunotherapy applied 6...
This study aims at evaluating the endometrial receptivity in uterus of pregnant rats exposed to nicotine via examination integrin expression by immunohistochemical effect.In this study, 16 healthy were divided into two groups control and each comprising eight rats. The randomised group given a certain amount before during pregnancy. Integrin was detected all staining. effect exposure on embryo implantation immunohistochemically pathologically evaluated.Comparison both revealed no difference...