A5053864011- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
Istanbul Medipol University
2022-2023
Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in lung. In context of cancer, IL-33-activated were found to bear anti-tumoral functions lung cancer promoted tumorigenesis colorectal cancer. The role remains addressed.We examined overall survival human non-small cell (NSCLC) patients according IL25 expression as well...
ABSTRACT It is now clear that group 2 innate lymphoid cells (ILC2) play crucial and sometimes opposing roles in the lung, such as restoring barrier function integrity after viral infections or, on contrary, exacerbating inflammation tissue damage allergic asthma. However, their role lung cancer still unclear. Here, we report human non-small cell patients bear increased frequencies of ILC2s tumors, normal peripheral blood (PB) compared to PB from healthy donors (HDs). Frequencies Foxp3 +...