A5082819078- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Kawasaki Disease and Coronary Complications
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Vascular Malformations and Hemangiomas
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Whipple's Disease and Interleukins
- Cardiovascular Disease and Adiposity
- Myasthenia Gravis and Thymoma
- Vascular anomalies and interventions
- Pediatric Hepatobiliary Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Liver Disease and Transplantation
- Atherosclerosis and Cardiovascular Diseases
- Pain Management and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and Medication Impact
- Blood groups and transfusion
Memorial Ankara Hospital
2024-2025
Gazi University
2020-2024
Biologic therapy has changed the prognosis of patients with rheumatologic disease. Despite all benefits biological agents, adverse events may occur due to their long-term use. The aim this study is analyze observed in pediatric who received treatment.
Bu çalışma, jüvenil idiyopatik artrit (JİA) hastalarında hastalık aktivitesi ile prognostik nutrisyonel indeks (PNI) arasındaki ilişkiyi incelemeyi amaçlamaktadır. Ayrıca, PNI’nın JİA’da bir biyobelirteç olarak kullanılabilirliğini değerlendirmek hedeflenmiştir. Oligoartiküler ve poliartiküler JİA tanısı alan hastalar, Jüvenil Artrit Hastalık Aktivite Skoru (JADAS) ölçümüne göre remisyon düşük aktivitesine sahip olanlar orta yüksek gösterenler olmak üzere iki gruba ayrıldı. İki grup arasında...
Aim: This study aims to compare the clinical and demographic characteristics of patients diagnosed with oligoarticular juvenile idiopathic arthritis (JIA) treated conventional disease-modifying antirheumatic drugs (cDMARDs) versus those requiring additional biologic DMARDs (bDMARDs). Additionally, it identify factors that necessitate inclusion bDMARDs in treatment regimen determine predictors long-term resistance. Materials Methods: Patients JIA were classified into two groups based on their...
Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and used in combination with systemic corticosteroids treatment of many childhood rheumatic diseases, such as lupus erythematosus (SLE), ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged new alternative modality over CYC for induction therapy childhood-onset diseases. Clinicians adopt different practices...
Abstract Juvenile idiopathic arthritis (JIA) presents with diverse phenotypes and can lead to significant morbidity. Obesity, affecting 5 23% of JIA patients, may exacerbate disease activity complicate management. This study evaluates the impact body mass index (BMI) on influence joint involvement BMI in patients. Between January 2012 June 2024, 225 patients were reviewed, 173 ultimately included based specific inclusion exclusion criteria. Treatments followed American College Rheumatology...
The exact effects of MEFV variants on inflammation are still under investigation, and reports unknown significance, particularly the E148Q variant, have been conflicting. Therefore, this study aims to investigate patients exhibiting heterozygosity, focusing diagnoses disease courses assist physicians in interpreting variant.
To evaluate the safety of canakinumab using real-world data in patients with systemic juvenile idiopathic arthritis (sJIA) and autoinflammatory diseases (AID).
Immunoglobulin (Ig) A vasculitis (IgAV), is the most common of childhood, a leucocytoclastic that affects small vessels skin, gastrointestinal (GI) tract, joints, and kidneys. Scrotal involvement relatively rare. In this study, we aimed to reveal clinical laboratory characteristics patients with scrotal in IgAV its relationship other features disease.A total number 301 male diagnosis between January 2005 2022 were retrospectively analysed. The divided into two groups as without involvement....
Familial Mediterranean fever (FMF) is an autoinflammatory disease which may cause endothelial dysfunction and arterial stiffness. In this study, we evaluated patients with FMF in terms of stiffness indicators investigated whether there was any difference according to colchicine response. This a single-center, prospective, case-control study conducted on pediatric FMF. Patients were categorized into 2 groups: monotherapy (group 1) who used anti-interleukin-1 (IL-1) plus 2). Patient age,...
Abstract Thymic tumors are very rare neoplasms in children and account for less than 1% of mediastinal pediatric patients. One‐third the patients present with symptoms related to compression tumor mass on surrounding anatomic structures, paraneoplastic syndromes such as myasthenia gravis, pure red cell aplasia, acquired hypogammaglobulinemia, connective tissue disorders, which rarely occur thymic tumors. Herein, we report a case carcinoma mimicking disease symmetrical polyarthritis...
The antinuclear antibody (ANA) test is frequently used for the identification of patients who are at a high risk developing autoimmune rheumatological diseases. aim this study to evaluate final diagnoses applied pediatric rheumatology outpatient clinic with positive ANA result. In study, medical records 283 children had positivity between January 2010 and 2022 were evaluated retrospectively. All younger than 18 years age diagnosis followed up in department least 6 months. majority females...
Amaç: Bu çalışmada skrotal tutulumu olan immunglobulin A (IgA) vasküliti tanısı alan çocuk hastaların değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: 1 Mart 2019- Ekim 2022 tarihleri arasında IgA alan, klinik demografik özellikleri, olmayan özellikleriyle karşılaştırılmıştır. Bulgular: 159 erkek hastanın 15 (%9,5)’inde tutulum saptandı. Skrotal olmayanlara göre tanı yaşı daha küçüktü (p=0,004). olmayanlarda gastrointestinal yüksek saptandı (p=0,021). Hastaların %60’ında bilateral...
<title>Abstract</title> Background In light of the accepted association between familial Mediterranean fever (FMF) and inflammatory bowel disease (IBD), as well limited previous research on this subject, study aimed to investigate prevalence IBD among individuals diagnosed with FMF explore clinical features genetic mutations present in patients IBD. Methods The was conducted 2006 2022. Patients were included. Patient records reviewed for demographic data, presenting symptoms their duration,...
Juvenile idiopathic arthritis (JIA) is a common chronic rheumatic disease in children, requiring careful management to reduce both short- and long-term morbidity. In this study, our objective was assess the clinical features of patients diagnosed with JIA who received intra-articular corticosteroid injections (IACI).
Granulomatous polyangiitis (GPA) is the most common anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), characterized by necrotizing inflammation of small and medium-sized vessels. It can affect various organs, particularly lung, kidneys, upper respiratory tract, ears, skin. Diagnosis AAV poses significant challenges due to its diverse clinical features. This report presents two interesting cases GPA: one with rare ocular involvement, who subsequently developed end-stage kidney...
Portal hypertension (PH) and its complications have a significant impact on morbidity mortality. This study aimed to evaluate the etiology; clinical, laboratory, endoscopic findings; treatment approaches; long-term outcomes; prognosis of pediatric PH.This retrospective included 222 patients diagnosed with PH between 1998 2016, data encompassing radiological features; treatments; were analyzed.The most common causes portal vein thrombosis (20.3%), progressive familial intrahepatic cholestasis...
Objectives: The study aimed to determine whether there is a relationship between the age at diagnosis and clinical, laboratory, prognostic features in pediatric immunoglobulin A vasculitis (IgAV) patients. Patients methods: In this study, 539 IgAV patients (298 males, 241 females; mean age: 7.74±3.36 years; range, 1 17.8 years) were retrospectively evaluated January 2005 July 2020. clinical findings was analyzed by univariate logistic regression analysis. Factors associated with renal...
<b>Objectives:</b> Biological agents are frequently used in inflammatory diseases childhood. We aim to determine the incidence of latent tuberculosis infection (LTBI) and disease (TB) during follow-up due use biological agents. <b>Methods:</b> Between 2008-2019, all 194 patients who were followed up pediatric pulmonology department terms LTBI TB occurance while using included study. Tuberculin skin test (TST), interferon gamma release assay (IGRA) tests lung imaging (chest X-ray and/or...