A5030801113- Occupational Health and Performance
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Injury Epidemiology and Prevention
- Health, Environment, Cognitive Aging
- Agricultural safety and regulations
- Computational Drug Discovery Methods
- Pesticide Residue Analysis and Safety
- Chemical Thermodynamics and Molecular Structure
- Sports injuries and prevention
- Mental Health Research Topics
- Water Treatment and Disinfection
- Environmental Chemistry and Analysis
- Sports Performance and Training
- Carcinogens and Genotoxicity Assessment
- Indoor Air Quality and Microbial Exposure
- Birth, Development, and Health
- Skin Protection and Aging
Masaryk University
2018-2024
RECETOX
2018-2019
The CELSPAC – FIREexpo biomonitoring study investigates the long-term effects of chemical exposure on firefighters' wellness and fitness. It aims to provide science-based measures minimize health risks firefighting occupation. Here, we present design, cohort profile, first results with respect internal per- polyfluoroalkyl substances (PFAS) polycyclic aromatic hydrocarbons (PAH) levels in participants. Participants (n = 166) were divided into three subcohorts: i) newly recruited...
Firefighting is one of the most hazardous occupations due to exposure per- and polyfluoroalkyl substances (PFAS) polycyclic aromatic hydrocarbons (PAHs). Such suspected affect cardiometabolic profile, e.g., liver function serum lipids. However, only a few studies have investigated impact this specific among firefighters. Men included in CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited training 58), controls 54). They completed questionnaires provided 1–3...
Abstract Introduction Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs associated outcomes is limited. Objective We aimed characterise among Czech men, including possible occupational firefighters, its predictors, associations liver function, serum lipids oxidative stress. Methods 165 participants (including 110 firefighters) provided urine...
Excellence in exposome research and chemical risk assessment (CRA) relies on robust capacities, innovative technologies, skilled human resources. Research infrastructures are vital providing access to these resources driving innovation. Over recent decades, Europe has developed numerous infrastructures, including EIRENE RI (Research Infrastructure for Environmental Exposure Assessment Europe), the first EU infrastructure dedicated exposome. aims integrate interdisciplinary data, offering...
Human health risk assessment of chemical mixtures is complex due to the almost infinite number possible combinations chemicals which people are exposed on a daily basis. biomonitoring (HBM) approaches can provide inter alia information that in our body at one point time. Network analysis applied such data may insight into real-life by visualizing exposure patterns. The identification groups more densely correlated biomarkers, so-called “communities”, within these networks highlights...
Increased wildfire activity increases the demands on fire rescue services and firefighters' contact with harmful chemicals. This study aimed to determine exposure toxic metal(loid)s its association lipid profile. CELSPAC-FIREexpo participants (including 110 firefighters) provided urine blood samples quantify urinary levels of (arsenic, cadmium (Cd), mercury, lead (Pb)), serum biomarkers (cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), high-density (HDL), triglycerides (TG))....
Introduction: The present study aimed to investigate the association between five-factor personality model (FFM), physical fitness, and activity (PA), effect of firefighting skills training on condition in firefighter recruits. Methods: Data 58 newly-recruited firefighters from CELSPAC–FIREexpo human biomonitoring were used. sampling protocol was structured entry phase testing 5th week training, final 10th training. During testing, participants filled out International Physical Activity...
BACKGROUND AND AIM: Benzotriazoles (BTRs), mostly used as corrosion inhibitors, have been classified high-production-volume chemicals of emerging concern due to wide distribution in the environment (including human tissues) and significant toxicological data gaps. This study aims evaluate genotoxic effects BTRs on liver stem cells assess exposure levels Czech male population. METHOD: HL1-hT1 were for Comet assay genotoxicity 5 frequently benzotriazoles – 1H-benzotriazole (BTR),...
BACKGROUND AND AIM: Firefighting is associated with exposure to per- and polyfluoroalkyl substances (PFAS) polycyclic aromatic hydrocarbons (PAHs), which are suspected affect the cardiometabolic profile, including liver function serum lipids. However, only a few studies have investigated impact of this specific among firefighters. Our study aims investigate associations between firefighters´ PFAS PAHs biomarkers METHOD: CELSPAC-FIREexpo included professional firefighters (n=52), newly...