Ítalo Karmann Aventurato
A5060541634- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Olfactory and Sensory Function Studies
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Cancer-related cognitive impairment studies
- Optical Imaging and Spectroscopy Techniques
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- HIV-related health complications and treatments
- Atherosclerosis and Cardiovascular Diseases
- Ultrasound and Hyperthermia Applications
Universidade Estadual de Campinas (UNICAMP)
2020-2025
Brazilian Institute of Neuroscience and Neurotechnology
2021-2024
Hospital de Clínicas da Unicamp
2021-2023
Universidade Federal de São Paulo
2017
Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety...
Abstract Although some studies have shown neuroimaging and neuropsychological alterations in post-COVID-19 patients, fewer combined neuropsychology evaluations of individuals who presented a mild acute infection. Here we investigated cognitive dysfunction brain changes group mildly infected individuals. We conducted cross-sectional study 97 consecutive subjects (median age 41 years) without current or history psychiatric symptoms (including anxiety depression) after infection, with median 79...
Abstract Objective The intricate neuroanatomical structure of the cerebellum is longstanding interest in epilepsy, but has been poorly characterized within current corticocentric models this disease. We quantified cross‐sectional regional cerebellar lobule volumes using structural magnetic resonance imaging 1602 adults with epilepsy and 1022 healthy controls across 22 sites from global ENIGMA‐Epilepsy working group. Methods A state‐of‐the‐art deep learning‐based approach was employed that...
Abstract Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, the long-term dysfunction has been frequently observed after mild infection. Here we show spectrum of cerebral impact SARS-CoV-2 infection ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to acute damage confirmed brain tissue samples extracted orbitofrontal...
Abstract COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms associated altered cerebral cortical thickness. Using an independent cohort, we histopathological signs brain damage in 25% who died COVID-19. All the affected tissues exhibited foci SARS-CoV-2 infection replication, particularly astrocytes. Infection neural stem cell-derived...
The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies. Here we performed a large diffusion MRI study PD, integrating data from 17 cohorts worldwide, identify stage-specific profiles white matter differences. Diffusion-weighted 1654 participants diagnosed PD (age: 20–89 years; 33% female) 885...
COVID-19 is primarily a respiratory disease; however, there also evidence that it causes endothelial damage in the microvasculature of several organs. The aim present study to characterize vivo microvascular reactivity peripheral skeletal muscle severe patients.This prospective observational carried out Spain, Mexico and Brazil. Healthy subjects patients admitted intermediate (IRCU) intensive care units (ICU) due hypoxemia were studied. Local tissue/blood oxygen saturation (StO2) local...
Abstract Background Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non‐motor functioning remain be elucidated. Objective To quantify cross‐sectional lobule volumes using three dimensional T1‐weighted anatomical brain magnetic resonance imaging from global ENIGMA‐PD working group. Methods Cerebellar parcellation was performed deep learning‐based approach 2487 people PD 1212...
ABSTRACT Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations who did not require hospitalization. Therefore, we conducted a cross-sectional study of 87 consecutive, non-hospitalized individuals, with median 54 days the laboratory confirmation COVID-19. We performed structured interviews, neurological examination, 3T-MRI scans. The MRI...
Abstract Background The progression of Parkinson’s disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies, particularly regarding involvement white matter (WM) tracts. Here we performed largest diffusion MRI study PD date, integrating data from 17 cohorts worldwide, identify stage-specific profiles WM differences. Methods...
The intricate neuroanatomical structure of the cerebellum is longstanding interest in epilepsy, but has been poorly characterized within current cortico-centric models this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural MRI 1,602 adults with epilepsy and 1,022 healthy controls across twenty-two sites from global ENIGMA-Epilepsy working group.
<h3>Objective:</h3> Evaluate the effect of COVID-19 presumed viral strains on different cognitive domains. <h3>Background:</h3> Cognitive dysfunction (CD) is a frequent and debilitating symptom long-COVID syndrome with negative impact survivors' productivity quality life. It unknown whether there are strain-specific effects cognition. <h3>Design/Methods:</h3> We used Fiocruz database (http://www.genomahcov.fiocruz.br) to separate 452 subjects (15 years education; 88 days after diagnosis)...
<h3>Objective:</h3> To compare patterns of grey matter atrophy (GMA) in post-COVID syndrome according to four different strains SARS-CoV-2 <h3>Background:</h3> The neuropsychiatric symptoms the are frequent and debilitating represents a major public health concern. Unfortunately, neither physiopathology nor underlying cerebral alterations understood. <h3>Design/Methods:</h3> We analyzed 3T T1 MRI 300 subjects (non-hospitalized, median age 40 years, 209 women, an average 150 days from...
Invasiveness limits current neuromodulation approaches for treating Parkinson's disease (PD). Low-intensity focused ultrasound (LIFUS) is a viable non-invasive alternative to modulate the cortico-subcortical networks involved in PD. In this study, an intramembrane cavitation model was used simulate effects of ultrasonic stimulation subthalamic nucleus simplified validated network. Simulation results from single neuron and network models show stimulus effective producing neuronal excitation...
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder that has become increasingly prevalent around the world and can be characterized in vivo by amyloid‐beta peptide hyperphosphorylated tau protein. Subjective cognitive decline (SCD) mild impairment (MCI) are potential previous stages of AD dementia. Behavioral psychological symptoms common SCD MCI, but their biological basis still not clarified. This study aims to investigate correlations between neuropsychiatric...
Abstract Background Individuals with Mild Cognitive Impairment (MCI) are at greater risk of developing Alzheimer's disease (AD). Previous studies have shown that physical exercise is a protective factor against the clinical evolution dementia in MCI. Lower muscle strength levels associated AD incidence. Physical exercises can also promote improvements brain networks' functional connectivity (FC). However, influence resistance exercise, which significantly impacts development muscular and...
Abstract Background Alzheimer's disease (AD) pathophysiology is complex and not completely known. Emerging new biomarkers that evaluate synaptic function (VILIP‐1, neurogranin), co‐pathology (alpha‐synuclein), neurodegeneration (NFL) are potential candidates to be incorporated into the early AD diagnosis. To better understand relevance of these biomarkers, we evaluated correlations between their CSF concentrations with whole‐brain grey matter volumes in SCD MCI, according amyloid status (A‐...
Abstract Background Alzheimer’s disease (AD) pathophysiology is complex and not completely known. Emerging new biomarkers that evaluate synaptic function (VILIP‐1, neurogranin), co‐pathology (alpha‐synuclein), neurodegeneration (NFL) are potential candidates to be incorporated into the early AD diagnosis. To better understand relevance of these biomarkers, we evaluated correlations between their CSF concentrations with whole‐brain grey matter volumes in SCD MCI, according amyloid status (A‐...
The mechanisms underlying host HIV control hold much promise in the search for a functional cure. We investigated genomic signatures elite controllers or rapid progressors following recent infection and correlates of immune reconstitution during combination antiretroviral therapy. characterized HIV-specific longitudinal transcriptional response peripheral blood mononuclear cells from controllers, progressors, responders non-responders using RT-qPCR array cohort recently HIV-infected...
Abstract Background: Little is known about the underpinning mechanisms of neurological dysfunction in post-COVID syndrome. Methods: We conducted a cross-sectional study 87 consecutive subjects after mild infection, with median 54 days diagnosis COVID-19. performed structured interviews, examinations, 3T-MRI scans, and neuropsychological assessments. The MRI included white matter investigation diffusion tensor images (DTI) functional connectivity resting-state (RS-fMRI). Results: Subjects...
<h3>Objective:</h3> To investigate brain connectivity and network properties with graph theory methods in TLE patients according to the presence or absence of HA. <h3>Background:</h3> Although temporal lobe epilepsy (TLE) unilateral hippocampal atrophy (HA) has been extensively investigated, impact bilateral HA on networks' efficiency remains unknown. <h3>Design/Methods:</h3> We analyzed 216 3T-MRI resting-state images (median age: 48 years; 122 women): 92 LEFT-HA, 70 RIGHT-HA, 25...