Glaucia M. Almeida
A5044774658- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Inflammasome and immune disorders
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Tryptophan and brain disorders
- Dermatological and COVID-19 studies
- Neuroscience and Neuropharmacology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- COVID-19 and Mental Health
- Cholinesterase and Neurodegenerative Diseases
- Inflammation biomarkers and pathways
- Streptococcal Infections and Treatments
- Poverty, Education, and Child Welfare
- Receptor Mechanisms and Signaling
- COVID-19 Impact on Reproduction
- Herpesvirus Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant-based Medicinal Research
- Viral Infections and Vectors
Universidade de São Paulo
2018-2025
Fundação Oswaldo Cruz
2025
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved pathophysiology. A cohort 32 hospitalized with a confirmed diagnosis healthy controls were enrolled. The concentration was augmented plasma, tracheal aspirate, lung...
Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety...
Abstract Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, the long-term dysfunction has been frequently observed after mild infection. Here we show spectrum of cerebral impact SARS-CoV-2 infection ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to acute damage confirmed brain tissue samples extracted orbitofrontal...
Abstract Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to failure. These also cytokine storm syndrome, and organ dysfunctions, which is a clinical picture resembles sepsis. Considering neutrophil extracellular traps (NETs) have been described as an important factors of tissue damage in sepsis, we investigated whether NETs would be produced participate the lung damage. A cohort 32 hospitalized with confirmed diagnosis respective healthy controls were...
Abstract COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms associated altered cerebral cortical thickness. Using an independent cohort, we histopathological signs brain damage in 25% who died COVID-19. All the affected tissues exhibited foci SARS-CoV-2 infection replication, particularly astrocytes. Infection neural stem cell-derived...
COVID-19 causes more than million deaths worldwide. Although much is understood about the immunopathogenesis of lung disease, a lot remains to be known on neurological impact COVID-19. Here, we evaluated immunometabolic changes using astrocytes in vitro and dissected brain areas SARS-CoV-2 infected Syrian hamsters. We show that alters proteins carbon metabolism, glycolysis, synaptic transmission, many which are altered diseases. Real-time respirometry evidenced hyperactivation further...
Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated neurological complications genomic RNA detected cerebrospinal fluid from patients, suggesting its neuroinvasive Motivated by these findings, neurotropism neuropathogenesis of have investigated vivo murine models, which do not fully recapitulate the complexity human brain. Here we used slice cultures adult brains to investigate whether capable...
ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils, adenoids, and secretions in children without symptoms of COVID-19, with no history recent upper airway infection. We studied 48 undergoing tonsillectomy due to snoring/OSA or recurrent tonsillitis between October 2020 September 2021. Nasal cytobrushes, nasal washes, tonsillar tissue fragments obtained at surgery were tested by RT-qPCR, immunohistochemistry (IHC), flow cytometry, neutralization assay. detected...
Deciphering the molecular pathways associated with N-methyl-D-aspartate receptor (NMDAr) hypofunction and its interaction antipsychotics is necessary to advance our understanding of basis schizophrenia, as well capacity treat this disease. In regard, development human brain-derived models that are amenable studying neurobiology schizophrenia may contribute filling gaps left by widely employed animal models. Here, we assessed proteomic changes induced NMDA glutamate antagonist MK-801 on brain...
ABSTRACT Coronaviruses belong to a well-known family of enveloped RNA viruses and are the causative agent common cold. Although seasonal coronaviruses do not pose threat human life, three members this family, i.e., SARS-CoV, MERS-CoV recently, SARS-CoV2, may cause severe acute respiratory syndrome lead death. Unfortunately, COVID-19 has already caused more than 4.4 million deaths worldwide. much is better understood about immunopathogenesis lung disease, important information systemic...
ABSTRACT In the present study, we show that SARS-CoV-2 can infect palatine tonsils and adenoids in children without symptoms of COVID-19, with no history recent upper airway infection. We studied 48 undergoing tonsillectomy due to snoring/OSA or recurrent tonsillitis between October 2020 September 2021. Briefly, nasal cytobrush (NC), wash (NW) tonsillar tissue fragments obtained at surgery were tested by RT-PCR, immunohistochemistry (IHC), flow cytometry neutralization assay. detected...
Organotypic, or slice cultures, have been widely employed to model aspects of the central nervous system functioning in vitro. Despite potential cultures neuroscience, studies using adult tissue prepare such are still scarce, particularly those from human subjects. The use is attractive enhance understanding neuropathologies, as they hold unique properties typical mature brain lacking slices produced rodent (usually neonatal) tissue. This protocol describes how collected living donors...
Organotypic, or slice cultures, have been widely employed to model aspects of the central nervous system functioning in vitro. Despite potential cultures neuroscience, studies using adult tissue prepare such are still scarce, particularly those from human subjects. The use is attractive enhance understanding neuropathologies, as they hold unique properties typical mature brain lacking slices produced rodent (usually neonatal) tissue. This protocol describes how collected living donors...