A5018294225- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Pediatric health and respiratory diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Single-cell and spatial transcriptomics
- Long-Term Effects of COVID-19
- Gut microbiota and health
- Business and Management Studies
- Multiple Sclerosis Research Studies
- Gastrointestinal motility and disorders
- Monoclonal and Polyclonal Antibodies Research
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
Brigham and Women's Hospital
2023-2024
Harvard University
2023-2024
Universidade de São Paulo
2014-2022
Abstract Background Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and key mediators of mucosal tolerance microbiota composition. Little is known about mechanisms by which γδ interact with gut to maintain tolerance. Results We found that antibiotic treatment impaired oral depleted cells, suggesting necessary cells. also mice deficient for (γδ −/− ) had an altered composition led small intestine (SI) immune dysregulation Accordingly, colonizing WT resulted SI...
COVID-19 causes more than million deaths worldwide. Although much is understood about the immunopathogenesis of lung disease, a lot remains to be known on neurological impact COVID-19. Here, we evaluated immunometabolic changes using astrocytes in vitro and dissected brain areas SARS-CoV-2 infected Syrian hamsters. We show that alters proteins carbon metabolism, glycolysis, synaptic transmission, many which are altered diseases. Real-time respirometry evidenced hyperactivation further...
The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal induce a regulatory B (B10) cell population in offspring concert allergy inhibition. C57BL/6 females were or immunized OVA and mated normal WT males. Their evaluated at 3 days of age 20 neonatal immunization. Human peripheral cells from atopic non-atopic individuals also evaluated. Preconception induced B10 offspring, IL-10...
Our group recently demonstrated that IgG modulates αβT cell cytokine production during the maturation process in human thymus. The effects of this modulation are repertoire dependent and can exert a systemic long-term impact.To investigate whether from atopic dermatitis (AD) patients modulate infant intrathymic TCD4 TCD8 cells vitro.Thymic tissues were obtained newborn children nonatopic mothers, thymocytes cultured for 6 days with purified AD or intravenous immunoglobulin (IVIG) mock...
The precise mechanism involved in the acquisition of IL-17+ profile γδT cells, ligands responsible for this change, and whether default is acquired during intrathymic maturation need to be elucidated.This study aimed evaluate IL-17-producing cells are present airways tolerant offspring from allergen-sensitized mothers possible implication maternal IgG generation these cells.Female mice were immunized or not, allergic response, frequency cell subsets cytokine production analysed by flow...
The regulatory effect of allergic responses induced by IgG antibodies on human intra-thymic cells has not been reported in the literature. aim this study was to evaluate possible differential purified from atopic and non-atopic individuals αβT cell cytokine production. Thymic tissues were obtained 14 patients who less than 7 d old. Additionally, blood samples collected volunteers. Thymocytes peripheral mononuclear cultured with or IgG, intracellular production assessed. Purified did...
Abstract Cellular therapy with mesenchymal stem cells (MSCs) is a huge challenge for scientists, as little translational relevance has been achieved. However, many studies using MSCs have proved their suppressive and regenerative capacity. Thus, there still need better understanding of biology the establishment newer protocols, or to test unexplored tissue sources. Here, we demonstrate that murine endometrial-derived (meMSCs) suppress Experimental Autoimmune Encephalomyelitis (EAE)....
Over the last decade, our group has demonstrated that murine preconception immunization with allergens a protective effect on allergy development in offspring. The model used present study allowed us to compare induction by ovalbumin (OVA) and dust mite extract from Dermatophagoides pteronyssinus (Dp). Female mice were immunized OVA or Dp. Pups non-immune mothers at 3 days old (do) same antigen for maternal immunization. offspring analyzed 20 do. Preconceptional Dp did not increase IgE serum...
Regulatory B (B10) cells can control several inflammatory diseases, including allergies; however, the origin of peripheral B10 is not fully understood, and involvement primary lymphoid organs (PLOs) as a site maturation known. Here, using murine model allergy inhibition mediated by maternal immunization with ovalbumin (OVA), we aimed to evaluate whether mature in thymus IgG mediate this process. Female mice were immunized OVA, offspring thymus, bone marrow, spleen, lung, serum samples...
Abstract Studies about thymic B cells are scarce in the literature, but it was suggested that they can exert modulatory and regulatory functions on immune system. Thymic play some role regulating most frequent allergic background worldwide, atopy induced by mite Dermatophagoides pteronyssinus (Der p). Here, we aimed to evaluate if polyclonal IgG repertoire produced Der p-atopic individuals influence homing cytokine profile of human derived from non-atopic children aged less than seven days....
Major depressive disorder (MDD) is a complex psychiatric condition with significant global impact. This study applied genomic-driven integrative systems neuroimmunology approach to analyze transcriptomic data from 3,114 individuals (1,877 MDD patients and 1,237 controls). The analysis revealed neuroimmunological alterations, indicating cross-talk between the immune nervous in peripheral blood mononuclear cells (PBMCs) specific brain regions. Among 31 shared genes, NEGR1, PPP6C, SORCS3, PAX6...
ABSTRACT Coronaviruses belong to a well-known family of enveloped RNA viruses and are the causative agent common cold. Although seasonal coronaviruses do not pose threat human life, three members this family, i.e., SARS-CoV, MERS-CoV recently, SARS-CoV2, may cause severe acute respiratory syndrome lead death. Unfortunately, COVID-19 has already caused more than 4.4 million deaths worldwide. much is better understood about immunopathogenesis lung disease, important information systemic...
The regulation of offspring allergy development mediated by maternal immunization was evidenced several groups, and this mechanism seems to involve the induction regulatory T cells (Tregs) on offspring. Here, we aimed evaluate whether effect Tregs occurs as a result peripheral or central modulation. Briefly, C57BL/6 female mice were immunized with OVA in Alum alone boosted saline only after 10 20 days. Non-immunized serum, thymus spleen evaluated at 3 days old, some groups pups submitted...
In the last few years our group has been studying mechanisms involved in inhibition of allergy offspring mediated by preconception maternal immunization, but these are not fully understood. Such that we have studied aimed at passive transfer antibodies and its influence on immune status.To evaluate whether immunization could modulate intracellular Th1/Th2 profiles offspring.C57BL/6 female wild type mice (WT), interleukin (IL)-10-/- or CD28-/- were immunized with ovalbumin (OVA) mated...
The mechanisms through which maternal immunization can modulate offspring thymic maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether OVA-immunization inhibit the Th17 cells on thymus. C57BL/6 females were immunized with OVA in Alum or alone and mated normal WT males. Offspring thymus was evaluated at three 20 days age. demonstration that allergy development validated our experimental protocol. First, observed expression R γT IL-17 molecules immature T...
Abstract The associations between human concussions and subsequent sequelae of chronic neuropsychiatric cardiovascular diseases such as hypertension have been reported; however, little is known about the underlying biological processes. We hypothesized that dietary changes, including a high-salt diet, disrupt bidirectional gut–brain axis, resulting in worsening neuroinflammation emergence behavioural phenotypes period after repetitive closed head injury adolescent mice. Adolescent mice were...
Anais do I Congresso Virtual de Estudantes e Profissionais Engenharia Ambiental Sanitária (978-65-5941-018-7) - Proposta De Implantação Um Sistema Gestão Para Uma Pequena Empresa Do Setor Alimentício Tibau Sul/Rn