A5092795426- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Glioma Diagnosis and Treatment
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- T-cell and Retrovirus Studies
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Vectors
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Mosquito-borne diseases and control
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Advanced Biosensing Techniques and Applications
- Bioinformatics and Genomic Networks
- Malaria Research and Control
- Liver Disease and Transplantation
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatitis C virus research
- Virus-based gene therapy research
Universidade de São Paulo
2023-2025
Universidade Federal de São Paulo
2025
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes which remain poorly understood. This study explored associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, clinical manifestations COVID-19. Using cross-sectional analysis 244 individuals, we applied multivariate variance, principal component analysis, multinomial regression to examine relationships AAB levels...
Gliomas are the most common and aggressive primary tumors of central nervous system. Dysregulated transcription factors (TFs) genes have been implicated in glioma progression, yet these tumors' overall structure gene regulatory networks (GRNs) remains undefined. We analyzed transcriptional data from 989 gliomas The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) to address this. GRNs were reconstructed using RTN package which identifies regulons-sets regulated by a TF based on co-expression...
Major depressive disorder (MDD) is a complex psychiatric condition with significant global impact. This study applied genomic-driven integrative systems neuroimmunology approach to analyze transcriptomic data from 3,114 individuals (1,877 MDD patients and 1,237 controls). The analysis revealed neuroimmunological alterations, indicating cross-talk between the immune nervous in peripheral blood mononuclear cells (PBMCs) specific brain regions. Among 31 shared genes, NEGR1, PPP6C, SORCS3, PAX6...
ABSTRACT The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates potential association between specific autoantibodies (AABs), notably those that targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS) related molecules, diverse clinical manifestations COVID-19, commonly observed in patients autoimmune conditions, including rheumatic diseases,...
ABSTRACT Acute leukemias (ALs) are complex hematological disorders, and accurate diagnosis is crucial for guiding treatment decisions predicting patient outcomes. While changes in cell marker levels well documented, the impact of these on relationships through an integrative systems approach remains uncharacterized. To address this gap, we conducted a 12-year study investigating 41 markers, including ontogenic markers those used to diagnose both common rare leukemia types, using...
ABSTRACT Major depressive disorder (MDD) involves complex neuroimmune interactions linked to gene modulation. Our study investigates synaptic-related dysregulation in peripheral blood mononuclear cells (PBMCs) from MDD patients, showing how these immune mirror neural processes. Using RNA-seq data, we identified 1,383 differentially expressed genes (DEGs) related crosstalk, with 49 DEGs effectively distinguishing patients controls based on synaptic functions. Synaptic genes, enriched for...