A5066663966- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Vagus Nerve Stimulation Research
- Cancer-related gene regulation
- Kawasaki Disease and Coronary Complications
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Receptor Mechanisms and Signaling
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Epigenetics and DNA Methylation
- Adrenal Hormones and Disorders
Maimonides Medical Center
2020-2025
New York University
2022-2024
NYU Langone Health
2020-2023
George Washington University
2022
SUNY Downstate Health Sciences University
2022
State University of New York
2022
New York Medical College
2022
Mount Sinai Medical Center
2022
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
Abstract COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand role these immune globulins in pathogenesis disease, it is important explore spectra. Here we show, by a cross-sectional study 246 individuals, that autoantibodies targeting G protein-coupled receptors (GPCR) and RAS-related molecules associate clinical severity COVID-19. Patients moderate severe disease are characterized higher levels than healthy controls those mild...
Abstract Diamond Blackfan anemia (DBA) is a heterogeneous genetic disorder characterized by red cell aplasia, congenital anomalies, and predisposition to cancer. Although incompletely understood, the erythroid failure in DBA appears result from accelerated apoptosis of affected progenitors/precursors. One what be multiple genes, coding for ribosomal protein RPS 19, has been cloned. Even within multiplex families individuals may vary dramatically as degree anemia, response treatment presence...
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, chronic respiratory disease). However, despite well-known influence of age on autoantibody biology in health disease, its impact developing severe COVID-19 remains poorly explored. Here, we performed cross-sectional study autoantibodies directed against 58 targets associated with autoimmune diseases...
<h3>Importance</h3> Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in the United States are still emerging. <h3>Objective</h3> To elucidate SARS-CoV-2 and symptom onset a culturally linked community across 5 states States. <h3>Design, Setting, Participants</h3> This cross-sectional study included adults (aged ≥18 years) recruited from orthodox Jewish (California, Connecticut, Michigan, New Jersey, York) 3 geographically distinct areas of between May 13...
COVID-19 is a heterogenous disease resulting in long-term sequela predisposed individuals. It not uncommon that recovering patients endure non-respiratory ill-defined manifestations, including anosmia, and neurological cognitive deficit persisting beyond recovery-a constellation of conditions are grouped under the umbrella syndrome. Association between autoimmune responses individuals was shown several studies.To investigate against neuronal CNS autoantigens SARS-CoV-2-infected patients, we...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID‐19 patients may develop a broad spectrum autoimmune diseases due to reasons not fully understood. Even so, the landscape induced by SARS‐CoV‐2 remains uncharted territory. To gain more insight, we carried out comprehensive assessment known be linked...
Cross-reactive immunity between SARS-CoV-2 and other related coronaviruses has been well-documented, it may play a role in preventing severe COVID-19. Epidemiological studies early the pandemic showed geographical association high influenza vaccination rates lower incidence of infection. We, therefore, analyzed whether exposure to A virus (IAV) antigens could influence T cell repertoire response SARS-CoV-2, indicating heterologous immune these 2 unrelated viruses. Using artificial...
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes which remain poorly understood. This study explored associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, clinical manifestations COVID-19. Using cross-sectional analysis 244 individuals, we applied multivariate variance, principal component analysis, multinomial regression to examine relationships AAB levels...
Background COVID-19 can cause some individuals to experience chronic symptoms. Rates and predictors of symptoms are not fully elucidated. Objective To examine occurrence patterns post-acute sequelae SARS-CoV2 infection (PASC) symptomatology their relationship with demographics, acute anti-SARS-CoV-2 IgG antibody responses. Methods A multi-stage observational study was performed adults (≥18 years) from 5 US states. Participants completed two rounds electronic surveys (May-July 2020; April-May...
ABSTRACT Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) outcomes due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, diabetes, chronic respiratory disease). However, despite well-known influence of age on autoantibody biology in health & disease, its impact developing severe COVID-19 remains poorly explored. Here, we performed cross-sectional study autoantibodies directed against 58 targets associated...
ABSTRACT We evaluated the durability of IgG responses specific to SARS-CoV-2 nucleocapsid (N), receptor binding domain (RBD), and spike (S) antigens in saliva up 8 months after RT-PCR-confirmed COVID-19 using a multiplex salivary assay. estimated half-life 64 days (d) (95% CI: 49, 80 d) for N, 100 d RBD 58, 141 d), 148 62, 238 S saliva, consistent with estimates previously reported blood. Saliva can serve as an alternative blood monitor humoral immune on large scale following infection...
The complex relationship between clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and individual immune responses is not fully elucidated.To examine phenotypes symptomatology their with positive anti-SARS-CoV-2 IgG antibody responses.An observational study was performed adults (≥18 years) from 5 US states. Participants completed an electronic survey underwent testing to nucleocapsid protein May July 2020. Latent class analysis used identify...
Abstract Unbiased antibody profiling can identify the targets of an immune reaction. A number likely pathogenic autoreactive antibodies have been associated with life-threatening SARS-CoV-2 infection; yet, many additional autoantibodies remain unknown. Here we present Molecular Indexing Proteins by Self Assembly (MIPSA), a technique that produces ORFeome-scale libraries proteins covalently coupled to uniquely identifying DNA barcodes for analysis sequencing. We used MIPSA profile circulating...
ABSTRACT The SARS-CoV-2 infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may develop a wide spectrum autoimmune diseases due to reasons not fully understood. Even so, the landscape induced by remains uncharted territory. To gain more insight, we carried out comprehensive assessment known be linked diverse observed in patients, cohort 248 individuals, which171 were...
ABSTRACT The coronavirus disease 2019 (COVID-19) can evolve to clinical manifestations resembling systemic autoimmune diseases, with the presence of autoantibodies that are still poorly characterized. To address this issue, we performed a cross-sectional study 246 individuals determine whether targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS)-related molecules were associated COVID-19-related outcomes. Moderate severe patients exhibited highest autoantibody...
A pediatric inflammatory multisystem disorder temporally associated with exposure to SARS-CoV-2 has been described in communities high rates of COVID-19. We present the case a 14-year-old boy who was treated for symptoms shock, elevated antibodies, developed headaches, diplopia, and blurred vision found have bilateral optic disc edema an abducens palsy. CASE REPORT presented emergency department fever, nausea, malaise, maculopapillary chest rash (Fig. 1), pain April 2020. Blood pressure...
ABSTRACT The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates potential association between specific autoantibodies (AABs), notably those that targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS) related molecules, diverse clinical manifestations COVID-19, commonly observed in patients autoimmune conditions, including rheumatic diseases,...
Effective strategies are needed to improve vaccine acceptance. This study sought determine if a peer-led education intervention embedded within community medical practices increases parental acceptance of pediatric pneumococcal conjugate vaccination.
ABSTRACT Background Multiple factors affecting COVID19 vaccine induced antibody responses in SARS-CoV2 uninfected immunosuppressed solid organ transplant recipients have been reported; however, there is still a lack of information on non-ACE2 competing cross-CoV2 neutralizing functional antibodies these cohorts, and similarly the efficacy prior CoV2-infected individuals not well understood. Methods was compared panel kidney heart who were either CoV2 (n=63) or infected (n=13) to receiving...
Importance SARS-CoV-2 is a rapidly evolving virus with many strains. Although vaccines have proven to be effective against earlier strains of the virus, efficacy vaccination status later still an area active research. Objective To determine if was associated symptomatology due infection by SARS-CoV-2. Design This cross-sectional survey sent adult Jewish population from December 2021 March 2022. Setting population-based study communities throughout tristate area. The subjects were recruited...